Afleveringen
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Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In todayâs conversation we discussed menopause and itâs effect on womenâs health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer.
Episode Show Notes: https://livelongerworld.com/p/jgarrison
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.com/Find me (Aastha) on Twitter: https://twitter.com/aasthajs
DR. JENNIFER GARRISON LINKS:Lab: http://garrisonlab.com/ Donate to her research: https://gcrle.org/CONNECT WITH AASTHA, LIVE LONGER WORLD:Twitter: https://twitter.com/aasthajsNewsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/Airchat: https://www.getairchat.com/aasthajs
TIMESTAMPS:00:00 Intro1:38 Jennifer Garrison Intro2:32 Ovarian aging & health risks5:23 Progression of Ovarian aging8:49 Menopause and negative health effects10:34 Hypothalamus & Mind body communication14:40 Reproductive & Equality Initiatives18:21 Biological Clock for Reproductive aging20:20 Tweaking hormonal cues22:07 Number of eggs vs. Quality of eggs25:00 Genetics in ovarian aging26:21 Understanding family history27:39 Evolutionary benefit to Menopause?32:33 Hormone Replacement Therapy (HRT) & its benefits38:28 Narrow window for HRT40:08 Perimenopause42:56 Womenâs health funding45:14 Average age girls start menstruating is declining49:10 PCOS52:42 Athletes and irregular cycles56:36 Individualized menopause symptoms1:00:38 Exercise and ovarian aging1:02:00 Support Jennifer's work
Episode Show Notes: https://livelongerworld.com/p/jgarrisonPOPULAR EPSIODES:- Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA- Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg- Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8- Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8- Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member.
Aging is universal. Let's unite in this fight.Stay in good health - Aastha.
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Dr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity.
Episode Show Notes: https://livelongerworld.substack.com/p/gwestFind the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/aasthajs
DR. GEOFFREY WEST LINKS:Profile: https://www.santafe.edu/people/profile/geoffrey-westBook: https://amzn.to/3Xtl7wUCONNECT WITH AASTHA, LIVE LONGER WORLD:
Newsletter: https://livelongerworld.substack.com/
Twitter: â https://twitter.com/aasthajs
Instagram: https://www.instagram.com/aasthajs/
Airchat: https://www.getairchat.com/aasthajs
TIMESTAMPS:1:35 Context on Dr. West's book Scale9:00 Networks in biology & cities22:50 Scaling laws in longevity
32:33 Upper limit to human age?
39:08 Quantifying Caloric restriction
41:52 Metabolism & Body temperature
49:05 Scaling laws in age-related damage
56:35 Scaling body sizes across species
1:01:38 Scaling laws in drug dosage (LSD & Elephants)
1:11:06 Drug dosage in children (Tylenol & babies)
1:13:44 Vaccine dosage scaling laws
1:17:51 Sleep & Aging in different organisms
1:31:22 Early stimulation for child development
1:36:35 Fasting, meal frequency & digestive time
1:39:10 Sleep demands with work & physical activity
1:43:40: Scaling laws in cities, companies & universities
2:02:00 Outro
POPULAR EPSIODES:
Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA
Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg
Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8
Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8
Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member.Aging is universal. Let's unite in this fight.Stay in good health - Aastha.
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Zijn er afleveringen die ontbreken?
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All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad
Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions!
There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austadâs work focuses on what long-lived animal species can teach us about living longer and healthier lives. His lab works on exotic species, like clams that live more than 500 years, and hydra that donât age at all, in order to discover aging treatments. He also tries to uncover the mysteries around why men and women respond differently to longevity therapeutics.
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/aasthajz
DR. STEVEN AUSTAD LINKS:
Website: https://www.stevenaustad.com/
Twitter: https://twitter.com/StevenAustad
Faculty page: https://www.uab.edu/cas/biology/people/faculty/steven-n-austad
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/aasthajz
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/aasthajz/
TIMESTAMPS:
0:00 Training lions
7:15 Learning from Long-lived species
9:55 Bowhead whales live 200 years
12:55 House sparrows & longevity
14:40 Study "successful" animals
18:10 Naked Mole Rats
20:45 What do bowhead whales die from?
26:05 Why do ocean animals live longest?
31:05 Beyond Caloric Restriction
36:00 Intermittent Fasting & Circadian Rhythm
42:40 Caloric Restriction for Healthy people?
46:24 Will coffee shorten your life?
49:43 The Blue Zone Myth
55:50 Young Blood, I can't get you of out my Mind
1:00:26 Hormones & Health (Growth Hormones for longevity?)
1:05:18 Sex differences in longevity
Episode Show Notes: https://livelongerworld.substack.com/p/saustad
POPULAR EPSIODES:
- Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA
- Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg
- Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8
- Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8
- Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo
Thanks for watching & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
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All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2
Dr. Dom DâAgostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition.
This is Part 2 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the ketogenic diet for exercise performance, keto for women & children, Dom's diet & supplement routine + more! Hope you enjoy the episode!
Part 1 with Dom on Ketogenic diets for Brain Health and Longevity: https://livelongerworld.substack.com/p/dom1
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/aasthajz
SUPPORT LIVE LONGER WORLD:
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
DOM D'AGOSTINO LINKS:
KetoNutrition: https://ketonutrition.org/
Website: https://linktr.ee/Domdagostino
Twitter: https://twitter.com/DominicDAgosti2
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/aasthajz
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/aasthajz/
TIMESTAMPS:
0:00 Ketogenic diet for muscle performance
0:50 Domâs supplements & modified keto diet
3:20 Keto, NAD+, NMN 7:12 Biomarkers tracked by Dom
9:30 LDL, Triglycerides, Fatty Foods & Keto diet
14:15 Domâs routine & supplements
18:09 Melatonin benefits for anti-cancer & antioxidant
22:37 Ketogenic diet for women
30:55 Ketogenic diet for children
32:48 Genetic aspect to keto diet?
38:32 Metformin for suppressing cancer
46:30 Ketogenic diet & Alzheimerâs
54:40 Exercise for mental health
55:53 Keto for exercise performance & bodybuilding
59:32 Endogenous metabolite & psychedelics
1:09:05 Connect with me (Aastha)
Episode Show Notes: https://livelongerworld.substack.com/p/dom2
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. If you like the podcast, please leave a review on Apple podcasts.
Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
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All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1
Dr. Dom DâAgostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition.
This is Part 1 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the history of ketogenic diets, keto for brain health and neuroprotective seizures, keto for longevity benefits, weight training, caloric restriction and more. Hope you enjoy the episode!
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/livelongerworld
SUPPORT LIVE LONGER WORLD:
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
DOM D'AGOSTINO LINKS:
KetoNutrition: https://ketonutrition.org/
Website: https://linktr.ee/Domdagostino
Twitter: https://twitter.com/DominicDAgosti2
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
TIMESTAMPS:
0:00 Ketogenic diet is not optimal for everyone
0:56 Dom DâAgostino Intro
1:29 Plant-based ketogenic diet
3:20 Ketogenic diet & brain protection against seizures
16:40 Ketone Esters & Salts
19:29 Does the brain need glucose?
21:37 Intermittent Ketosis & Fasting Mimicking Diet
25:17 Cyclic Ketogenic diet for longevity
28:40 Devices for tracking ketosis
30:30 Ketogenic diet for longevity vs. Caloric restriction
37:50 Keto diet for cancer prevention
41:57 Keto diet, Insulin pathway, and glucose
46:50 Time restricted eating benefits
50:17 Dom vs. Layne Norton on Joe Rogan podcast
51:40 Muscle for longevity (especially for women)
56:10 Support Live Longer World
Episode Show Notes: https://livelongerworld.substack.com/p/dom1
Thanks for watching & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.
Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
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All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple
Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection.
Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Naziâs and he was the first person to put the metabolic story of cancer on the map. The famous âWarburg Effectâ that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him.
It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation!
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/livelongerworld
SUPPORT LIVE LONGER WORLD:
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
SAM APPLE LINKS:
Ravenous book: https://amzn.to/3yT9qpd
Website: http://www.samapple.com/
Twitter: https://twitter.com/Sam_Apple1
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
TIMESTAMPS:
0:00 Cancer as a disease of modern societies
1:27 Otto Warburg & the Cancer-Metabolic Connection
2:27 Warburgâs research on respiration
4:02 Why was cancer skyrocketing in Western societies?
9:17 Warburg Effect: Warburgâs research on cancer cells
15:00 Why do cancer cells take up so much glucose?
17:44 Cancer-Diet Connection
21:44 Cancer, Ketogenic diets & Fasting
23:43 Hibernation of the metabolic story of cancer
27:20 Hitlerâs connection with cancer
30:07 Warburgâs arrogance
31:51 Why does cancer need glucose?
38:46 Warburgâs stigma: connecting with Naziâs
40:51 Is insulin responsible for cancer?
48:00 Science is not immune from politics
50:24 Prostate cancer & obesity
52:13 Pendulum swing in cancer research
54:40 Mitochondria & Cancer Connection
57:07 Naziâs fixation on cancer
Episode Show Notes: https://livelongerworld.substack.com/p/sapple
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
Thanks for listening & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.
Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
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All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev
Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Womenâs hospital, where he runs his own lab. We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium.
Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his labâs work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice.
Itâs important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation!
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld
Find me on Twitter: https://twitter.com/livelongerworld
VADIM GLADYSHEV LINKS:
Website: https://gladyshevlab.bwh.harvard.edu/2022
Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:00 Vadim Gladyshev Intro
1:28 Live Longer World
2:17 Seleniumâs dual role in aging (the good, the bad, the ugly)
11:27 Antagonistic Pleiotropy
13:53 Selenium & Cancer
15:58 Selenium Dosage (donât get too much!)
18:30 Reactive Oxygen Species, Antioxidants & Aging
22:30 Fundamental basis of Aging
24:09 Aging is damage
29:20 Single cell Epigenetic Clocks
34:22 Aging in the Womb
42:16 Parentâs lifestyle for aging in embryo
44:14 Rapamycin during development
49:06 Other compounds
51:53 Slowing Aging vs. Rejuvenation
56:08 New projects being worked on
57:17 Confidence level in extending lifespan within 30 years
59:17 Support Live Longer World
Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
Thanks for watching & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.
Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
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Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young. In todayâs conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more.
If you want to understand how to think about your risk assessment for cardiovascular disease and how to prevent it, this conversation is for you.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/eweiss
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
ETHAN WEISS LINKS:
Website: https://profiles.ucsf.edu/ethan.weiss
Twitter: https://twitter.com/ethanjweiss
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:00 Welcome to Live Longer World
0:44 Misconceptions of heart disease / young people with heart disease
4:01 Predictors of heart disease
6:59 LDL vs HDL; Triglycerides
12:51 Small-dense LDL vs. Large fluffy LDL
16:09 Dietary Carbohydrates & heart disease risk
25:50 Inflammation & Cardiovascular risk
26:43 Lipoproteins, ApoB, Lp(a)
31:31 Statins, PCSK9 inhibitors
32:45 ApoB as gold standard risk marker
36:50 Triglycerides & Insulin resistance
40:00 Saturated Fat
42:42 Variation in Cholesterol measurement
46:03 Body composition as marker for heart disease risk
51:23 Ketogenic diets & heart health
56:43 Keyto breath sensor
1:01:46 Stress & heart disease
1:04:44 Growth hormone & heart disease
1:07:46 On the shortness of life
1:10:52 Support & Connect with
Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/eweiss
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
Thanks for listening & if you enjoy the episode, let's spread the message on longevity.
Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
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Dr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology.
His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. His work on bioelectric signals has important applications for how we understand cancer, regenerative medicine and even aging. In fact, he is collaborating with David Sinclair to see how his work can be applied to reverse aging.
Michael Levinâs work is fascinating and will surely leave you thinking. I hope you enjoy the conversation!
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/mlevin
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
MICHAEL LEVIN LINKS:
Website: https://ase.tufts.edu/biology/labs/levin/
Twitter: https://twitter.com/drmichaellevin
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/
Live Longer World Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:40 How do cells decide what to build?
10:05 DNA is insufficient for dictating collective intelligence of cells
19:00 Anatomical Complier (End game)
22:24 History of Cellular Collective Intelligence & Ala Turing
26:30 Regenerative Medicine & Morphoceuticals
38:05 Cells forming new anatomies
44:53 Cancer as a morphogenetic problem
55:16 David Sinclair, Bioelectrics to reverse aging
57:44 Synthetic Wombs & Artificial Life
59:41 Support Live Longer World!
Episode Show Notes: https://livelongerworld.substack.com/p/mlevin
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
If you enjoy my work and wish to support it, consider sharing it with a friend or two and leaving a review on Apple podcasts.
And if you are further inclined to show love and support, you can donate on Patreon: patreon.com/livelongerworld
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
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Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations Iâve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements.
In todayâs episode, you will learn:
- The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin
- 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril
- Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin
- Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more
- Richardâs thoughts on lifespan vs. healthspan
All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
RICHARD MILLER LINKS:
Website: http://www.richmillerlab.com/
Photography: https://richardmiller.zenfolio.com/
Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:55 Richard Miller Intro
1:51 Richard Miller Wildlife photography
3:30 ITP - the gold standard for testing longevity drugs & winning drugs
10:51 Rapamycin, Rapamycin + Acarbose
18:48 Rapamycin + Acarbose Dosing Schedule
20:15 Combination of drugs, Rapamycin + Metformin
21:56 17-Alpha Estradiol
25:45 Canagaflozin
31:34 Does Richard take the 4 winning drugs?
32:46 3 Drugs that have small lifespan effects & promising
36:30 GPLD-1 & shared mechanisms in longevity drugs
44:04 Resveratrol in ITP
46:27 NR, NMN
52:34 Curcumin, Green Tea Extract, MCT Oil
54:54 Fisetin & Senolytics
56:12 Why most published research findings are false
1:00:03 Healthspan biomarkers at the ITP
1:02:38 Can you have healthspan without lifespan?
1:07:37 Fish Oil, Spermidine, Sulforophane
1:12:13 Unpublished data Richard is excited about
1:17:47 Flying Pigs & Aubrey De Grey
1:20:00 Exponential rise in aging research
Episode Show Notes: https://livelongerworld.substack.com/p/rmiller
Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast.
Aging is universal. Let's unite in this fight.
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Yuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming.
Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian Armstrong, CEO of Coinbase. If youâre not familiar with this trending, hyped (rightly so this time - it is pretty amazing!) research on Epigenetic reprogramming and Yamanaka factors to turn cells back to a younger state, we dive into it in todayâs episode!
As a last point to Yuriâs introduction, because Iâd be remiss if I didnât mention it, you may have heard of his name recently because he was in fact one of the first people to talk about the COVID lab leak theory and wrote extensively on it. This speaks to his scientific mindset and desire to uncover the truth.
In todayâs episode, you will learn:
- The Strong Epigenetic Theory of Aging, as coined by Yuri (He calls David Sinclairâs theory The Weak Epigenetic Theory of Aging)
- Epigenetic Reprogramming using Yamanaka factors to turn the cell into a younger state
- What is it and what are the open questions in the field
- What are the cancer risks associated with it
- Why Yuri believes in Cryonics
- Why Yuri got interested in uncovering the COVID-19 Lab Leak theory
- Pharma in Russia
If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
YURI DEIGIN LINKS:
Twitter: https://twitter.com/ydeigin
LinkedIn: https://www.linkedin.com/in/yurideigin/
Medium: https://yurideigin.medium.com/
YouthBio Therapeutics: https://youthbiotx.com/
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
00:00 "We're not crazy"
0:37 100% life extension & translation to humans
4:28 Aging is potentially an engineering problem
12:45 Strong Epigenetic Theory of Aging
19:26 Epigenetic Reprogramming
29:00 Risk of Cancer with Epigenetic reprogramming
33:00 Rejuvenation without cancer risk?
38:30 Why Cryonics Makes Sense
48:00 COVID Lab Leak Theory
53:45 Pharma in Russia
58:40 Optimism in Longevity
1:00:50 Aging is Universal. Let's Unite in this Fight
Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin
Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast.
Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
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Dr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation.
In todayâs episode, you will learn: Cellular Senescence and itâs dual role in protecting against cancer but also causing tissue aging The role of senolytic drugs to protect against age-associated cellular senesence The connection between the mitochondria and cellular senescence The Developmental theory of aging (Aging begins in the womb!)If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/padams
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber
Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
PETER ADAMS LINKS:
Lab Website & Bio: http://www.padamslab.org/pages/members.html
Peter Adams Twitter: https://twitter.com/AdamsBioAging
Peter's Recent Publications: https://www.sbpdiscovery.org/our-scientists/peter-d-adams-phd
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS & EPISODE SHOW NOTES: https://livelongerworld.substack.com/p/padams
Thanks for listening & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
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My guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinsonâs disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinsonâs disease.
In todayâs conversation, we discussed the science behind a dysfunctional mitochondria and mitophagy, the relationship between the mitochondria and Parkinsonâs disease, and whether certain mitochondria boosting supplements like Urolithin A and Coq10 that delay the onset of Parkinsonâs. We also discussed the biological simulation and computational biology platform used by Vincere - they use AI systems that can be used to screen drugs & targets and simulate cell environments. Finally, we spoke about the challenges with running a biotech company.
Andy comes from a background in technology and computer science background and he combined it with biology to create Vincere Biosciences.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/alee
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
ANDY LEE / VINCERE BIO LINKS:
Vincere Website: https://vincerebio.com/
Andy Lee Twitter: https://twitter.com/andy_d_lee
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon page: https://www.patreon.com/livelongerworld
Podcast All Platforms: https://anchor.fm/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
Premium Subscriber Benefits: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:00 Live Longer World Intro
0:34 Andy Lee & Vincere Bio Intro
1:55 Vincere & the connection between mitochondria & Parkinson's
7:39 Mitophagy & Parkinsonâs disease
16:29 Role of USP30 in Mitochondria & Parkinsonâs
22:26 Vincere small molecules testing
25:18 Other pathways affected during Parkinson's
30:53 Computation Biology Platform used by Vincere
36:50 Urolithin A & Coq10 to help with Parkinsonâs
39:45 Biomarkers for Mitophagy
42:46 Too much mitophagy?
44:50 Challenges running a biotech company
48:19 Path forward for Vincere
49:36 Support, share and follow Live Longer World!
Want Summarized Notes on Key Points Discussed in the Podcast? Gain access by signing up as a premium subscriber. Your contribution supports my work and the advancement of longevity science!
Key points summarized in the show notes for premium subscribers include:
1. The connection between Mitochondrial quality control & Parkinsonâs disease
2. Mitophagy and the science behind targeting the mitochondria
3. Overview of the Biological Simulation Platform used by Vincere Bio
4. Can compounds like Urolithin A & Coq10 that target the mitochondria delay Parkinsonâs
5. Challenges with running a Biotech Co.
Learn more on Premium Subscriber Benefits: https://www.livelongerworld.com/premium
Ep. Show notes: https://livelongerworld.substack.com/p/alee
-
My guest today is Dr. Bjorn Schumacher whose work focuses on the central role of DNA damage in the aging process. We discussed DNA damage accumulation with age, how DNA repair mechanisms play a role, how DNA damage in the reproductive cells can tell us a lot about aging, human fertility and reproductive capacity. We also discussed the role of p53 in cancer suppression, a new biological age clock being developed in his lab and how we should protect our skin from aging and thereby control DNA damage.
A lot of us have heard about the link between DNA damage and aging and this conversation really dives into it.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bschumacher
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
DR. BJORN SCHUMACHER LINKS:
Lab Website: https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-bjoern-schumacher
Twitter: https://twitter.com/schumacherbj
Author of the book: The Mysteries of Human Aging: Surprising Insights from a Science That's Still Young: https://amzn.to/3LyR3JU
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon page: https://www.patreon.com/livelongerworld
Podcast All Platforms: https://anchor.fm/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
Premium Subscriber Benefits: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:00 Live Longer World Intro
0:30 Bjorn Schumacher Intro
1:22 DNA Damage as Central to the Aging process
3:37 DNA repair with age
8:39 Premature aging; 2 distinct forms of DNA damage
14:15 How does an aging human survive with DNA damage & tamp down cancer?
18:20 Stress to reproductive cells builds up immunity in the body
24:41 Female reproduction, Menopause & DNA repair
27:46 p53 and itâs role in DNA repair
35:13 BiT Clock: New Biological Age Clock
43:59 Skin Aging and DNA damage
48:06 Stress in the intestine / gut can alter the chromosome
53:00 Germ cells are immortal
For links to DR. Bjorn Schumacher research discussed: https://livelongerworld.substack.com/p/bschumacher
Want Summarized Notes on Key Points Discussed in the Podcast?
Gain access by signing up as a premium subscriber. Your contribution supports my work the advancement of longevity science!
Key points summarized in the show notes for premium subscribers include:
The central role of DNA damage in the aging process What happens to our bodyâs DNA repair mechanism with age? DNA Damage in the germ cells (reproductive cells) promotes stress resistance in the body The role of p53 in suppressing cancer and in the DNA repair processLearn more: https://www.livelongerworld.com/premium
Thanks for listeni -
My guest today is Dr. David Gems who runs the C. Elegans Aging lab at the University College London. We had a fascinating discussion talking about emerging paradigms in the theories of aging. We discussed the hyperfunction theory or the programmatic theory of aging which gives a better integrated understanding of the different theories of aging that have been presented such as damage accumulation, evolutionary, antagonistic pleiotropy. It has been assumed that molecular damage is always the cause of aging, but the programmatic theory of aging shows that that might not be the case. We also discussed his critique of the hallmarks of aging and how there should be a better paradigm for the aging field. Lastly, we also discussed how research from his lab on C. Elegans might explain some of the conflict around whether sirtuins affect lifespan and how C. Elegans also show versions of this programmatic theory of aging, which can give us a better understanding of how to study aging.
Note: There is a point in the conversation (40:41) where David pulls up some slides to better explain the Multifactorial Model of Aging. So if you are listening to the audio version, you might want to refer to YouTube or the show notes.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/dgems
Support on Patreon: https://www.patreon.com/livelongerworld
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
DR. DAVID GEMS LINKS:
Lab Website: https://www.ucl.ac.uk/~ucbtdag/DGHistory.html
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon page: https://www.patreon.com/livelongerworld
Podcast All Platforms: https://anchor.fm/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
Premium Subscriber Benefits: https://www.livelongerworld.com/premium
TIMESTAMPS:
00:00 Live Longer World
00:25 David Gems Intro
1:47 History of the theories of aging
12:23 Hyperfunction / Programmatic Theory of Aging
24:57 Programmatic Theory of Aging in C. Elegans
36:59 Hyperfunction theory of Aging in Humans
40:41 Multifactorial Model of Aging 50:32 Mutation in C. Elegans affecting Sirtuin research?
59:57 Sirtuin research in humans & conflicting sirtuin research
1:04:44 Metformin affects the gut microbiome
1:07:41 Critique of the Hallmarks of Aging
1:16:12 Disruption in Early Life could lead to Aging related diseases
1:24:23 Support, share, and follow Live Longer World
To find links to David Gems research discussed, please refer to the show notes: https://livelongerworld.substack.com/p/dgems
Thanks for listening & if you enjoy the episode, please leave a review on Apple podcasts, support on Patreon, subscribe & share!
Stay in good health - Aastha.
-
My guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and childrenâs pajamas!
Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vitamins and minerals leads to accelerated aging. He came up with the Micronutrient triage theory, which says that when nutrient intake is insufficient, the body has a rationing mechanism and favors proteins needed for immediate survival at the expense of protection against future damage.
Dr. Bruce Ames is 93 years old and says that he is still exercising and eating healthy greens cooked by his lovely Italian wife! However, he says his cognitive capacity has slowed down (this is why we need rejuvenation therapies, even for the brain: listen to my episode with Dr. Jean Hebert who talks about Brain Aging and his strategy to reverse aging through replacement of the body parts: https://youtu.be/oerGUepWsH8).
I am grateful that I had a chance to converse with him on Vitamin D, longevity micronutrients, how micronutrient deficiency can lead to accelerated aging, his take on the science behind reversing aging, and his advice to younger people.
This is a shorter episode and I hope you learn more about the importance of micronutrients!
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bames
RELATED WRITING:
My newsletter post explaining the Micronutrient Triage theory: https://livelongerworld.substack.com/p/bruceames
My post on Longevity Foods (Nutrition Doesn't have to be so complicated): https://livelongerworld.substack.com/p/longevityfoods
Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Find me on Twitter: https://twitter.com/livelongerworld
Support on Patreon: https://www.patreon.com/livelongerworld
DR. BRUCE AMES LINKS:
Website: http://www.bruceames.org/
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon page: https://www.patreon.com/livelongerworld
Podcast All Platforms: https://anchor.fm/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
Premium Subscriber Benefits: https://www.livelongerworld.com/premium
TIMESTAMPS:
00:00 Live Longer World
00:36 Bruce Ames Intro
1:50 Micronutrient triage theory
5:40 Micronutrient deficiencies & age acceleration
9:10 Vitamin D for healthy aging
12:26 CHORI Bar
14:46 Measuring micronutrients (blood finger-prick)
16:55 Bruce Ames diet
18:19 Asthma caused by obesity / bad diet improved by CHORI bar
21:21 Dr. Ames lifestyle over the years
22:47 Importance of zinc
24:15 Nutrition is complicated
24:44 Dr. Ames last words & advice for young scientists
Thanks for listening & if you enjoy the episode, please like, leave a review on Apple podcasts, subscribe & share! Stay in good health - Aastha.
-
My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research. Dr. Kennedy's lab is working on different small molecules and natural products that could boost longevity.
In today's discussion, we spoke about the network concept of the hallmarks of aging, the longevity effects of natural products like Alpha-Ketoglutarate (AKG), Spermidine and Urolithin A, and why combining some of these supplements might not be prudent. We also spoke about comparing the different biomarkers of aging, what we can learn from the longevity of bats, and why basic science is important.
All platforms / Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/bkennedy
Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Support on Patreon: https://www.patreon.com/livelongerworld
DR. BRIAN KENNEDY LINKS:
Lab Website: https://medicine.nus.edu.sg/bch/faculty/brian-kennedy/
Twitter: https://twitter.com/BKennedy_aging
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon page: https://www.patreon.com/livelongerworld
Podcast All Platforms: https://anchor.fm/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
Premium Subscriber Benefits: https://www.livelongerworld.com/premium
DR. BRIAN KENNEDY RESEARCH DISCUSSED:
2020 Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877690/
2020 Aging Biomarkers: From Functional Tests to Multi-Omics Approaches: https://pubmed.ncbi.nlm.nih.gov/32084299/
2021 The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition: https://pubmed.ncbi.nlm.nih.gov/34060628/
2021 Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436907/
2020 The World Goes Bats: Living & Tolerating Viruses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341951/
2021 Yeast as a model organism for aging research: https://www.sciencedirect.com/science/article/pii/B9780128159620000081
Thanks for watching & if you enjoy the episode, please like, comment, subscribe & share! Stay in good health - Aastha.
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My guest today is Dr. Collin Ewald who is a professor at the Health Sciences department at ETH Zurich. His lab focuses on understanding the extracellular matrix (ECM) and how it changes with age. Collin explains the role of the ECM in tissue repair, muscle strength, and overall longevity. In fact, Collinâs lab is also working on establishing the ECM as a biomarker for health and disease risk. So, studying the ECM can indeed tell us a lot about the aging process and ways to intervene.
Think of the ECM as the environment that surrounds the cell or the proteins secreted from the cell. It holds our organs and tissues in place. Youâve probably heard of collagen protein - it is largely found in the ECM.
Why is the ECM relevant for longevity research? Turns out, the ECM changes with age. In fact, each cell has a unique ECM and cancer cells can be detected by their ECM composition type! There is also a connection between the ECM and the muscle, and damage to collagen with age results in weakening of our muscles.
We discuss changes in collagen with age, how sugar impacts collagen, cancer cells & ECM, the overexpression of certain collagens with age, changes in collagen causing muscle impairment with age, and longevity interventions his lab is studying to repair the impairment damage.
(This podcast can be a little technical, especially in the beginning, so Iâd recommend referring to the show notes for better understanding. The video version of the podcast also contains some explanations on the video slide itself.)
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/cewald
Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Support on Patreon: https://www.patreon.com/livelongerworld
DR. COLLIN EWALD LINKS:
Lab Website: https://www.ewaldlab.com/
Twitter: https://twitter.com/CollinEwald
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon page: https://www.patreon.com/livelongerworld
Podcast All Platforms: https://anchor.fm/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
Premium Subscriber Benefits: https://www.livelongerworld.com/premium
TIMESTAMPS:
Episode Page: https://livelongerworld.substack.com/p/cewald
YouTube: https://youtu.be/r1Y5wGSqKWA
DR. COLLIN EWALD RESEARCH:
The Matrisome during Aging and Longevity: https://www.karger.com/Article/FullText/504295
Collagen overexpression increasing lifespan: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352135/
Youthful and ageârelated matreotypes predict drugs promoting longevity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441316/
Doubling life near death: https://elifesciences.org/digests/71335/doubling-life-near-death
Thanks for watching & if you enjoy the episode, please like, comment, leave a review, subscribe & share! Stay in good health - Aastha.
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My guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley.
Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the animals shared blood and environment. The old mice became rejuvenated & younger. Theyâve also pioneered a process called the Neutral Blood Exchange or Therapeutic Blood Exchange, through which dilution of old blood plasma can lead to true rejuvenation in the brain & other tissues of mice to a younger state!!
Further, we touch upon Irina's work showing how decreased Oxytocin levels with age contributes to poor muscle function. Their research is incredibly exciting and we discuss all about it in todayâs episode.
Episode Show Notes: https://livelongerworld.substack.com/p/rejuvenation-via-plasma-dilution
Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
DR. CONBOY LINKS: Berkeley Lab: https://conboylab.berkeley.edu/
2021 Paper Plasma Dilution Improves Cognition and attenuates neuroinflammation in old mice: https://pubmed.ncbi.nlm.nih.gov/33191466/
2020 Paper Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288913/
2014 Paper Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration: https://www.nature.com/articles/ncomms5082
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Podcast All Platforms: https://anchor.fm/livelongerworld
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
TIMESTAMPS:
00:00 Live Longer World Intro
00:35 Irina & Michael Conboy Intro
1:08 Aging is slowdown in our repair machinery
2:55 Naked Mole Rats not extreme model for longevity
5:37 Heterochronic Parabiosis
16:00 Young Blood to Old Blood Exchange
19:19 Rejuvenation via Neutral Blood Exchange (NBE)
22:56 Old Blood Degenerates Young Mice
25:29 Rejuvenation Effects on Brain, Liver, Muscle through NBE
27:16 How long do effects of NBE last?
30:15 How is NBE working mechanistically? 2 waves of rejuvenation
33:38 Inhibiting TGF-beta & Increasing Oxytocin is rejuvenative
38:12 NBE vs. Senolytics
40:53 Unanswered Questions on NBE
43:13 Oxytocin & Muscle Functioning; Notch Signaling
48:12 Chickens & Ravens as Pets!
Thanks for listening & if you enjoy the episode, please like, subscribe & share! Stay in good health - Aastha.
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Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Healthâs (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging.
Dr. Barzilaiâs research interests are in the biology and genetics of aging, so he has done extensive work studying centenarians and supercentenarians some of which he discusses in todayâs episode and also in his book Age Later.
He is currently leading an international effort to approve drugs that can target aging. Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that multi-morbidities of aging can be delayed by metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans.
In today's episode, we discuss centenarian longevity genes, what makes centenarians live so long and the role of growth hormones in longevity. We also dive into metformin's healthspan benefits for longevity, metformin & COVID, if metformin blunts muscle mass and causes hypoglycemia, and metformin dosage.
Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/snbarzilai
FOLLOW NIR BARZILAI:
Profile: https://einsteinmed.edu/faculty/484/nir-barzilai/
Twitter: https://twitter.com/NirBarzilaiMD
Book: https://us.macmillan.com/books/9781250230867
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