Afleveringen

  • Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today’s conversation we discussed menopause and it’s effect on women’s health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer.

    Episode Show Notes: https://livelongerworld.com/p/jgarrison

    Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.com/Find me (Aastha) on Twitter: https://twitter.com/aasthajs

    DR. JENNIFER GARRISON LINKS:Lab: http://garrisonlab.com/ Donate to her research: https://gcrle.org/CONNECT WITH AASTHA, LIVE LONGER WORLD:Twitter: https://twitter.com/aasthajsNewsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/Airchat: https://www.getairchat.com/aasthajs

    TIMESTAMPS:00:00 Intro1:38 Jennifer Garrison Intro2:32 Ovarian aging & health risks5:23 Progression of Ovarian aging8:49 Menopause and negative health effects10:34 Hypothalamus & Mind body communication14:40 Reproductive & Equality Initiatives18:21 Biological Clock for Reproductive aging20:20 Tweaking hormonal cues22:07 Number of eggs vs. Quality of eggs25:00 Genetics in ovarian aging26:21 Understanding family history27:39 Evolutionary benefit to Menopause?32:33 Hormone Replacement Therapy (HRT) & its benefits38:28 Narrow window for HRT40:08 Perimenopause42:56 Women’s health funding45:14 Average age girls start menstruating is declining49:10 PCOS52:42 Athletes and irregular cycles56:36 Individualized menopause symptoms1:00:38 Exercise and ovarian aging1:02:00 Support Jennifer's work

    Episode Show Notes: https://livelongerworld.com/p/jgarrisonPOPULAR EPSIODES:- Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA- Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg- Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8- Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8- Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo

    Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member.

    Aging is universal. Let's unite in this fight.Stay in good health - Aastha.

  • Dr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity.

    Episode Show Notes: https://livelongerworld.substack.com/p/gwestFind the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/

    Find me (Aastha) on Twitter: https://twitter.com/aasthajs

    DR. GEOFFREY WEST LINKS:Profile: https://www.santafe.edu/people/profile/geoffrey-westBook: https://amzn.to/3Xtl7wUCONNECT WITH AASTHA, LIVE LONGER WORLD:

    Newsletter: https://livelongerworld.substack.com/

    Twitter: ⁠https://twitter.com/aasthajs

    Instagram: https://www.instagram.com/aasthajs/

    Airchat: https://www.getairchat.com/aasthajs

    TIMESTAMPS:1:35 Context on Dr. West's book Scale9:00 Networks in biology & cities22:50 Scaling laws in longevity

    32:33 Upper limit to human age?

    39:08 Quantifying Caloric restriction

    41:52 Metabolism & Body temperature

    49:05 Scaling laws in age-related damage

    56:35 Scaling body sizes across species

    1:01:38 Scaling laws in drug dosage (LSD & Elephants)

    1:11:06 Drug dosage in children (Tylenol & babies)

    1:13:44 Vaccine dosage scaling laws

    1:17:51 Sleep & Aging in different organisms

    1:31:22 Early stimulation for child development

    1:36:35 Fasting, meal frequency & digestive time

    1:39:10 Sleep demands with work & physical activity

    1:43:40: Scaling laws in cities, companies & universities

    2:02:00 Outro

    POPULAR EPSIODES:

    Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA

    Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg

    Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8

    Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8

    Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo

    Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member.Aging is universal. Let's unite in this fight.Stay in good health - Aastha.

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    Klik hier om de feed te vernieuwen.

  • All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad 

    Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions!   

    There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austad’s work focuses on what long-lived animal species can teach us about living longer and healthier lives. His lab works on exotic species, like clams that live more than 500 years, and hydra that don’t age at all, in order to discover aging treatments. He also tries to uncover the mysteries around why men and women respond differently to longevity therapeutics.   

    Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ 

    Find me (Aastha) on Twitter: https://twitter.com/aasthajz 

    DR. STEVEN AUSTAD LINKS: 

    Website: https://www.stevenaustad.com/

    Twitter: https://twitter.com/StevenAustad

    Faculty page: https://www.uab.edu/cas/biology/people/faculty/steven-n-austad 

    CONNECT WITH AASTHA, LIVE LONGER WORLD: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/aasthajz

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/aasthajz/ 

    TIMESTAMPS: 

    0:00 Training lions 

    7:15 Learning from Long-lived species 

    9:55 Bowhead whales live 200 years 

    12:55 House sparrows & longevity 

    14:40 Study "successful" animals 

    18:10 Naked Mole Rats 

    20:45 What do bowhead whales die from? 

    26:05 Why do ocean animals live longest? 

    31:05 Beyond Caloric Restriction 

    36:00 Intermittent Fasting & Circadian Rhythm 

    42:40 Caloric Restriction for Healthy people? 

    46:24 Will coffee shorten your life? 

    49:43 The Blue Zone Myth 

    55:50 Young Blood, I can't get you of out my Mind 

    1:00:26 Hormones & Health (Growth Hormones for longevity?) 

    1:05:18 Sex differences in longevity 

    Episode Show Notes: https://livelongerworld.substack.com/p/saustad 

    POPULAR EPSIODES: 

    - Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA

    - Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg

    - Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8

    - Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8

    - Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo 

    Thanks for watching & if you enjoy the episode, let's spread the message on longevity.   

    You can support my work by sharing, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.  Aging is universal. Let's unite in this fight. Stay in good health - Aastha.  

  • All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2

    Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition.  

    This is Part 2 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the ketogenic diet for exercise performance, keto for women & children, Dom's diet & supplement routine + more! Hope you enjoy the episode!

    Part 1 with Dom on Ketogenic diets for Brain Health and Longevity: https://livelongerworld.substack.com/p/dom1

    Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/

    Find me (Aastha) on Twitter: https://twitter.com/aasthajz

    SUPPORT LIVE LONGER WORLD:

    Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium

    Patreon: https://www.patreon.com/livelongerworld

    One-Time support: https://www.paypal.com/paypalme/livelongerworld

    DOM D'AGOSTINO LINKS:

    KetoNutrition: https://ketonutrition.org/

    Website: https://linktr.ee/Domdagostino

    Twitter: https://twitter.com/DominicDAgosti2

    CONNECT WITH AASTHA, LIVE LONGER WORLD:

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/aasthajz

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/aasthajz/

    TIMESTAMPS:

    0:00 Ketogenic diet for muscle performance 

    0:50 Dom’s supplements & modified keto diet 

    3:20 Keto, NAD+, NMN 7:12 Biomarkers tracked by Dom 

    9:30 LDL, Triglycerides, Fatty Foods & Keto diet 

    14:15 Dom’s routine & supplements 

    18:09 Melatonin benefits for anti-cancer & antioxidant 

    22:37 Ketogenic diet for women 

    30:55 Ketogenic diet for children 

    32:48 Genetic aspect to keto diet? 

    38:32 Metformin for suppressing cancer 

    46:30 Ketogenic diet & Alzheimer’s  

    54:40 Exercise for mental health 

    55:53 Keto for exercise performance & bodybuilding 

    59:32 Endogenous metabolite & psychedelics 

    1:09:05 Connect with me (Aastha)

    Episode Show Notes: https://livelongerworld.substack.com/p/dom2

    Thanks for watching & if you enjoy the episode, let's spread the message on longevity. If you like the podcast, please leave a review on Apple podcasts.

    Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

  • All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1 

    Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition. 

    This is Part 1 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the history of ketogenic diets, keto for brain health and neuroprotective seizures, keto for longevity benefits, weight training, caloric restriction and more. Hope you enjoy the episode!  

    Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ 

    Find me (Aastha) on Twitter: https://twitter.com/livelongerworld 

    SUPPORT LIVE LONGER WORLD: 

    Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium

    Patreon: https://www.patreon.com/livelongerworld

    One-Time support: https://www.paypal.com/paypalme/livelongerworld 

    DOM D'AGOSTINO LINKS: 

    KetoNutrition: https://ketonutrition.org/

    Website: https://linktr.ee/Domdagostino

    Twitter: https://twitter.com/DominicDAgosti2

    CONNECT WITH AASTHA, LIVE LONGER WORLD: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/

    TIMESTAMPS: 

    0:00 Ketogenic diet is not optimal for everyone 

    0:56 Dom D’Agostino Intro 

    1:29 Plant-based ketogenic diet 

    3:20 Ketogenic diet & brain protection against seizures 

    16:40 Ketone Esters & Salts 

    19:29 Does the brain need glucose? 

    21:37 Intermittent Ketosis & Fasting Mimicking Diet 

    25:17 Cyclic Ketogenic diet for longevity 

    28:40 Devices for tracking ketosis 

    30:30 Ketogenic diet for longevity vs. Caloric restriction 

    37:50 Keto diet for cancer prevention 

    41:57 Keto diet, Insulin pathway, and glucose 

    46:50 Time restricted eating benefits 

    50:17 Dom vs. Layne Norton on Joe Rogan podcast 

    51:40 Muscle for longevity (especially for women) 

    56:10 Support Live Longer World

    Episode Show Notes: https://livelongerworld.substack.com/p/dom1

    Thanks for watching & if you enjoy the episode, let's spread the message on longevity.   

    You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.  

    Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

  • All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple

    Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection. 

    Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him.

    It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation!  

    Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/

    Find me (Aastha) on Twitter: https://twitter.com/livelongerworld 

    SUPPORT LIVE LONGER WORLD: 

    Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium

    Patreon: https://www.patreon.com/livelongerworld

    One-Time support: https://www.paypal.com/paypalme/livelongerworld 

    SAM APPLE LINKS: 

    Ravenous book: https://amzn.to/3yT9qpd

    Website: http://www.samapple.com/

    Twitter: https://twitter.com/Sam_Apple1

    CONNECT WITH AASTHA, LIVE LONGER WORLD: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/

    TIMESTAMPS: 

    0:00 Cancer as a disease of modern societies 

    1:27 Otto Warburg & the Cancer-Metabolic Connection 

    2:27 Warburg’s research on respiration 

    4:02 Why was cancer skyrocketing in Western societies? 

    9:17 Warburg Effect: Warburg’s research on cancer cells 

    15:00 Why do cancer cells take up so much glucose? 

    17:44 Cancer-Diet Connection 

    21:44 Cancer, Ketogenic diets & Fasting 

    23:43 Hibernation of the metabolic story of cancer 

    27:20 Hitler’s connection with cancer 

    30:07 Warburg’s arrogance 

    31:51 Why does cancer need glucose? 

    38:46 Warburg’s stigma: connecting with Nazi’s 

    40:51 Is insulin responsible for cancer? 

    48:00 Science is not immune from politics 

    50:24 Prostate cancer & obesity 

    52:13 Pendulum swing in cancer research 

    54:40 Mitochondria & Cancer Connection 

    57:07 Nazi’s fixation on cancer

    Episode Show Notes: https://livelongerworld.substack.com/p/sapple 

    Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1

    Thanks for listening & if you enjoy the episode, let's spread the message on longevity. 

    You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.

    Aging is universal. Let's unite in this fight. 

    Stay in good health - Aastha.

  • All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev 

    Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab.  We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium.   

    Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab’s work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice.  

    It’s important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation!  

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

    Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium 

    Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld

    Find me on Twitter: https://twitter.com/livelongerworld 

    VADIM GLADYSHEV LINKS: 

    Website: https://gladyshevlab.bwh.harvard.edu/2022 

    Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1 

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/

    Patreon: https://www.patreon.com/livelongerworld

    YouTube: https://www.youtube.com/c/LiveLongerWorld

    Premium Subscriber: https://www.livelongerworld.com/premium 

    TIMESTAMPS: 

    0:00 Vadim Gladyshev Intro 

    1:28 Live Longer World 

    2:17 Selenium’s dual role in aging (the good, the bad, the ugly) 

    11:27 Antagonistic Pleiotropy 

    13:53 Selenium & Cancer 

    15:58 Selenium Dosage (don’t get too much!) 

    18:30 Reactive Oxygen Species, Antioxidants & Aging 

    22:30 Fundamental basis of Aging 

    24:09 Aging is damage 

    29:20 Single cell Epigenetic Clocks 

    34:22 Aging in the Womb 

    42:16 Parent’s lifestyle for aging in embryo 

    44:14 Rapamycin during development 

    49:06 Other compounds 

    51:53 Slowing Aging vs. Rejuvenation 

    56:08 New projects being worked on 

    57:17 Confidence level in extending lifespan within 30 years 

    59:17 Support Live Longer World  

    Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev 

    Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 

    Thanks for watching & if you enjoy the episode, let's spread the message on longevity.   

    You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.

    Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

  • Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young.  In today’s conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more.   

    If you want to understand how to think about your risk assessment for cardiovascular disease and how to prevent it, this conversation is for you. 

    All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/eweiss

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  

    Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium  

    Support on Patreon: https://www.patreon.com/livelongerworld 

    One-Time support: https://www.paypal.com/paypalme/livelongerworld  

    ETHAN WEISS LINKS: 

    Website: https://profiles.ucsf.edu/ethan.weiss 

    Twitter: https://twitter.com/ethanjweiss  

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/ 

    Twitter: https://twitter.com/livelongerworld 

    Newsletter: https://livelongerworld.substack.com/ 

    Instagram: https://www.instagram.com/longevityfuture/ 

    Patreon: https://www.patreon.com/livelongerworld 

    YouTube: https://www.youtube.com/c/LiveLongerWorld 

    Premium Subscriber: https://www.livelongerworld.com/premium

    TIMESTAMPS: 

    0:00 Welcome to Live Longer World 

    0:44 Misconceptions of heart disease / young people with heart disease 

    4:01 Predictors of heart disease 

    6:59 LDL vs HDL; Triglycerides 

    12:51 Small-dense LDL vs. Large fluffy LDL 

    16:09 Dietary Carbohydrates & heart disease risk 

    25:50 Inflammation & Cardiovascular risk 

    26:43 Lipoproteins, ApoB, Lp(a) 

    31:31 Statins, PCSK9 inhibitors 

    32:45 ApoB as gold standard risk marker 

    36:50 Triglycerides & Insulin resistance 

    40:00 Saturated Fat 

    42:42 Variation in Cholesterol measurement 

    46:03 Body composition as marker for heart disease risk 

    51:23 Ketogenic diets & heart health 

    56:43 Keyto breath sensor 

    1:01:46 Stress & heart disease 

    1:04:44 Growth hormone & heart disease 

    1:07:46 On the shortness of life 

    1:10:52 Support & Connect with 

    Live Longer World  Episode Show Notes: https://livelongerworld.substack.com/p/eweiss

     Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 

    Thanks for listening & if you enjoy the episode, let's spread the message on longevity. 

    Aging is universal. Let's unite in this fight. 

    Stay in good health - Aastha.

  • Dr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology.  

    His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. His work on bioelectric signals has important applications for how we understand cancer, regenerative medicine and even aging. In fact, he is collaborating with David Sinclair to see how his work can be applied to reverse aging.  

    Michael Levin’s work is fascinating and will surely leave you thinking. I hope you enjoy the conversation!   

    All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/mlevin 

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

    Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium 

    Support on Patreon: https://www.patreon.com/livelongerworld

    One-Time support: https://www.paypal.com/paypalme/livelongerworld 

    MICHAEL LEVIN LINKS: 

    Website: https://ase.tufts.edu/biology/labs/levin/

    Twitter: https://twitter.com/drmichaellevin 

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/Patreon: https://www.patreon.com/livelongerworld

    YouTube: https://www.youtube.com/c/

    Live Longer World Premium Subscriber: https://www.livelongerworld.com/premium 

    TIMESTAMPS: 

    0:40 How do cells decide what to build? 

    10:05 DNA is insufficient for dictating collective intelligence of cells 

    19:00 Anatomical Complier (End game) 

    22:24 History of Cellular Collective Intelligence & Ala Turing 

    26:30 Regenerative Medicine & Morphoceuticals 

    38:05 Cells forming new anatomies 

    44:53 Cancer as a morphogenetic problem 

    55:16 David Sinclair, Bioelectrics to reverse aging 

    57:44 Synthetic Wombs & Artificial Life 

    59:41 Support Live Longer World!

    Episode Show Notes: https://livelongerworld.substack.com/p/mlevin 

    Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 

    If you enjoy my work and wish to support it, consider sharing it with a friend or two and leaving a review on Apple podcasts. 

    And if you are further inclined to show love and support, you can donate on Patreon: patreon.com/livelongerworld

    Thanks for watching & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. 

    Stay in good health - Aastha.  

  • Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I’ve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements.  

    In today’s episode, you will learn: 

    - The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin 

    - 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril 

    - Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin 

    - Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more 

    - Richard’s thoughts on lifespan vs. healthspan  

    All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller 

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

    Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium 

    Support on Patreon: https://www.patreon.com/livelongerworld

    One-Time support: https://www.paypal.com/paypalme/livelongerworld 

    RICHARD MILLER LINKS: 

    Website: http://www.richmillerlab.com/

    Photography: https://richardmiller.zenfolio.com/

    Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp 

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/

    Patreon: https://www.patreon.com/livelongerworld

    YouTube: https://www.youtube.com/c/LiveLongerWorld

    Premium Subscriber: https://www.livelongerworld.com/premium

    TIMESTAMPS: 

    0:55 Richard Miller Intro 

    1:51 Richard Miller Wildlife photography 

    3:30 ITP - the gold standard for testing longevity drugs & winning drugs 

    10:51 Rapamycin, Rapamycin + Acarbose 

    18:48 Rapamycin + Acarbose Dosing Schedule 

    20:15 Combination of drugs, Rapamycin + Metformin 

    21:56 17-Alpha Estradiol 

    25:45 Canagaflozin 

    31:34 Does Richard take the 4 winning drugs? 

    32:46 3 Drugs that have small lifespan effects & promising 

    36:30 GPLD-1 & shared mechanisms in longevity drugs 

    44:04 Resveratrol in ITP 

    46:27 NR, NMN 

    52:34 Curcumin, Green Tea Extract, MCT Oil 

    54:54 Fisetin & Senolytics 

    56:12 Why most published research findings are false 

    1:00:03 Healthspan biomarkers at the ITP 

    1:02:38 Can you have healthspan without lifespan? 

    1:07:37 Fish Oil, Spermidine, Sulforophane 

    1:12:13 Unpublished data Richard is excited about 

    1:17:47 Flying Pigs & Aubrey De Grey 

    1:20:00 Exponential rise in aging research

    Episode Show Notes: https://livelongerworld.substack.com/p/rmiller

    Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. 

    Aging is universal. Let's unite in this fight.

  • Yuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming.   

    Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian Armstrong, CEO of Coinbase. If you’re not familiar with this trending, hyped (rightly so this time - it is pretty amazing!) research on Epigenetic reprogramming and Yamanaka factors to turn cells back to a younger state, we dive into it in today’s episode!  

    As a last point to Yuri’s introduction, because I’d be remiss if I didn’t mention it, you may have heard of his name recently because he was in fact one of the first people to talk about the COVID lab leak theory and wrote extensively on it. This speaks to his scientific mindset and desire to uncover the truth.  

    In today’s episode, you will learn: 

    - The Strong Epigenetic Theory of Aging, as coined by Yuri (He calls David Sinclair’s theory The Weak Epigenetic Theory of Aging) 

    - Epigenetic Reprogramming using Yamanaka factors to turn the cell into a younger state  

    - What is it and what are the open questions in the field 

    - What are the cancer risks associated with it 

    - Why Yuri believes in Cryonics 

    - Why Yuri got interested in uncovering the COVID-19 Lab Leak theory  

    - Pharma in Russia

    If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes.

    All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin  

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  

    Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium  

    Support on Patreon: https://www.patreon.com/livelongerworld 

    One-Time support: https://www.paypal.com/paypalme/livelongerworld

    YURI DEIGIN LINKS: 

    Twitter: https://twitter.com/ydeigin

    LinkedIn: https://www.linkedin.com/in/yurideigin/

    Medium: https://yurideigin.medium.com/

    YouthBio Therapeutics: https://youthbiotx.com/ 

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/

    Patreon: https://www.patreon.com/livelongerworld

    YouTube: https://www.youtube.com/c/LiveLongerWorld

    Premium Subscriber: https://www.livelongerworld.com/premium

    TIMESTAMPS: 

    00:00 "We're not crazy" 

    0:37 100% life extension & translation to humans 

    4:28 Aging is potentially an engineering problem 

    12:45 Strong Epigenetic Theory of Aging 

    19:26 Epigenetic Reprogramming 

    29:00 Risk of Cancer with Epigenetic reprogramming 

    33:00 Rejuvenation without cancer risk? 

    38:30 Why Cryonics Makes Sense 

    48:00 COVID Lab Leak Theory 

    53:45 Pharma in Russia 

    58:40 Optimism in Longevity 

    1:00:50 Aging is Universal. Let's Unite in this Fight

    Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin

    Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. 

    Aging is universal. Let's unite in this fight. 

    Stay in good health - Aastha.

  • Dr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation.

    In today’s episode, you will learn: Cellular Senescence and it’s dual role in protecting against cancer but also causing tissue aging The role of senolytic drugs to protect against age-associated cellular senesence The connection between the mitochondria and cellular senescence The Developmental theory of aging (Aging begins in the womb!)

    If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes.

    All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/padams 

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast

    Sign up for Premium Subscriber

    Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium

    Support on Patreon: https://www.patreon.com/livelongerworld

    One-Time support: https://www.paypal.com/paypalme/livelongerworld

    PETER ADAMS LINKS:

    Lab Website & Bio: http://www.padamslab.org/pages/members.html

    Peter Adams Twitter: https://twitter.com/AdamsBioAging

    Peter's Recent Publications: https://www.sbpdiscovery.org/our-scientists/peter-d-adams-phd

    LIVE LONGER WORLD LINKS:

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/

    Patreon: https://www.patreon.com/livelongerworld

    YouTube: https://www.youtube.com/c/LiveLongerWorld

    Premium Subscriber: https://www.livelongerworld.com/premium

    TIMESTAMPS & EPISODE SHOW NOTES: https://livelongerworld.substack.com/p/padams 

    Thanks for listening & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

  • My guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinson’s disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinson’s disease. 

    In today’s conversation, we discussed the science behind a dysfunctional mitochondria and mitophagy, the relationship between the mitochondria and Parkinson’s disease, and whether certain mitochondria boosting supplements like Urolithin A and Coq10 that delay the onset of Parkinson’s. We also discussed the biological simulation and computational biology platform used by Vincere - they use AI systems that can be used to screen drugs & targets and simulate cell environments. Finally, we spoke about the challenges with running a biotech company.   

    Andy comes from a background in technology and computer science background and he combined it with biology to create Vincere Biosciences.

    All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/alee 

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

    Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium 

    Support on Patreon: https://www.patreon.com/livelongerworld

    One-Time support: https://www.paypal.com/paypalme/livelongerworld 

    ANDY LEE / VINCERE BIO LINKS: 

    Vincere Website: https://vincerebio.com/

    Andy Lee Twitter: https://twitter.com/andy_d_lee

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/

    Patreon page: https://www.patreon.com/livelongerworld

    Podcast All Platforms: https://anchor.fm/livelongerworld

    YouTube: https://www.youtube.com/c/LiveLongerWorld

    Apple Podcasts: https://apple.co/3eZAoAp

    Spotify: https://spoti.fi/3eZB6O5

    Google Podcasts: https://bit.ly/3HN0keG

    Premium Subscriber Benefits: https://www.livelongerworld.com/premium

    TIMESTAMPS: 

    0:00 Live Longer World Intro 

    0:34 Andy Lee & Vincere Bio Intro 

    1:55 Vincere & the connection between mitochondria & Parkinson's 

    7:39 Mitophagy & Parkinson’s disease 

    16:29 Role of USP30 in Mitochondria & Parkinson’s 

    22:26 Vincere small molecules testing 

    25:18 Other pathways affected during Parkinson's 

    30:53 Computation Biology Platform used by Vincere 

    36:50 Urolithin A & Coq10 to help with Parkinson’s 

    39:45 Biomarkers for Mitophagy 

    42:46 Too much mitophagy? 

    44:50 Challenges running a biotech company 

    48:19 Path forward for Vincere 

    49:36 Support, share and follow Live Longer World!

    Want Summarized Notes on Key Points Discussed in the Podcast? Gain access by signing up as a premium subscriber. Your contribution supports my work and the advancement of longevity science!   

    Key points summarized in the show notes for premium subscribers include: 

    1. The connection between Mitochondrial quality control & Parkinson’s disease 

    2. Mitophagy and the science behind targeting the mitochondria 

    3. Overview of the Biological Simulation Platform used by Vincere Bio 

    4. Can compounds like Urolithin A & Coq10 that target the mitochondria delay Parkinson’s 

    5. Challenges with running a Biotech Co.

    Learn more on Premium Subscriber Benefits: https://www.livelongerworld.com/premium

    Ep. Show notes: https://livelongerworld.substack.com/p/alee

  • My guest today is Dr. Bjorn Schumacher whose work focuses on the central role of DNA damage in the aging process. We discussed DNA damage accumulation with age, how DNA repair mechanisms play a role, how DNA damage in the reproductive cells can tell us a lot about aging, human fertility and reproductive capacity. We also discussed the role of p53 in cancer suppression, a new biological age clock being developed in his lab and how we should protect our skin from aging and thereby control DNA damage. 

    A lot of us have heard about the link between DNA damage and aging and this conversation really dives into it.  

    All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bschumacher 

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

    Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium 

    Support on Patreon: https://www.patreon.com/livelongerworld

    One-Time support: https://www.paypal.com/paypalme/livelongerworld 

    DR. BJORN SCHUMACHER LINKS: 

    Lab Website: https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-bjoern-schumacher

    Twitter: https://twitter.com/schumacherbj

    Author of the book: The Mysteries of Human Aging: Surprising Insights from a Science That's Still Young: https://amzn.to/3LyR3JU

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/

    Patreon page: https://www.patreon.com/livelongerworld

    Podcast All Platforms: https://anchor.fm/livelongerworld

    YouTube: https://www.youtube.com/c/LiveLongerWorld

    Apple Podcasts: https://apple.co/3eZAoAp

    Spotify: https://spoti.fi/3eZB6O5

    Google Podcasts: https://bit.ly/3HN0keG

    Premium Subscriber Benefits: https://www.livelongerworld.com/premium

    TIMESTAMPS: 

    0:00 Live Longer World Intro 

    0:30 Bjorn Schumacher Intro 

    1:22 DNA Damage as Central to the Aging process 

    3:37 DNA repair with age 

    8:39 Premature aging; 2 distinct forms of DNA damage 

    14:15 How does an aging human survive with DNA damage & tamp down cancer? 

    18:20 Stress to reproductive cells builds up immunity in the body 

    24:41 Female reproduction, Menopause & DNA repair 

    27:46 p53 and it’s role in DNA repair 

    35:13 BiT Clock: New Biological Age Clock 

    43:59 Skin Aging and DNA damage 

    48:06 Stress in the intestine / gut can alter the chromosome 

    53:00 Germ cells are immortal

    For links to DR. Bjorn Schumacher research discussed: https://livelongerworld.substack.com/p/bschumacher

    Want Summarized Notes on Key Points Discussed in the Podcast? 

    Gain access by signing up as a premium subscriber. Your contribution supports my work the advancement of longevity science!

    Key points summarized in the show notes for premium subscribers include:

    The central role of DNA damage in the aging process What happens to our body’s DNA repair mechanism with age? DNA Damage in the germ cells (reproductive cells) promotes stress resistance in the body The role of p53 in suppressing cancer and in the DNA repair process

    Learn more: https://www.livelongerworld.com/premium

    Thanks for listeni

  • My guest today is Dr. David Gems who runs the C. Elegans Aging lab at the University College London. We had a fascinating discussion talking about emerging paradigms in the theories of aging. We discussed the hyperfunction theory or the programmatic theory of aging which gives a better integrated understanding of the different theories of aging that have been presented such as damage accumulation, evolutionary, antagonistic pleiotropy. It has been assumed that molecular damage is always the cause of aging, but the programmatic theory of aging shows that that might not be the case. We also discussed his critique of the hallmarks of aging and how there should be a better paradigm for the aging field. Lastly, we also discussed how research from his lab on C. Elegans might explain some of the conflict around whether sirtuins affect lifespan and how C. Elegans also show versions of this programmatic theory of aging, which can give us a better understanding of how to study aging.

    Note: There is a point in the conversation (40:41) where David pulls up some slides to better explain the Multifactorial Model of Aging. So if you are listening to the audio version, you might want to refer to YouTube or the show notes.

    All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/dgems 

    Support on Patreon: https://www.patreon.com/livelongerworld  

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  

    DR. DAVID GEMS LINKS: 

    Lab Website: https://www.ucl.ac.uk/~ucbtdag/DGHistory.html 

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/

    Patreon page: https://www.patreon.com/livelongerworld

    Podcast All Platforms: https://anchor.fm/livelongerworld

    YouTube: https://www.youtube.com/c/LiveLongerWorld

    Apple Podcasts: https://apple.co/3eZAoAp

    Spotify: https://spoti.fi/3eZB6O5

    Google Podcasts: https://bit.ly/3HN0keG

    Premium Subscriber Benefits: https://www.livelongerworld.com/premium

    TIMESTAMPS: 

    00:00 Live Longer World 

    00:25 David Gems Intro 

    1:47 History of the theories of aging 

    12:23 Hyperfunction / Programmatic Theory of Aging 

    24:57 Programmatic Theory of Aging in C. Elegans 

    36:59 Hyperfunction theory of Aging in Humans 

    40:41 Multifactorial Model of Aging 50:32 Mutation in C. Elegans affecting Sirtuin research? 

    59:57 Sirtuin research in humans & conflicting sirtuin research 

    1:04:44 Metformin affects the gut microbiome 

    1:07:41 Critique of the Hallmarks of Aging 

    1:16:12 Disruption in Early Life could lead to Aging related diseases 

    1:24:23 Support, share, and follow Live Longer World

    To find links to David Gems research discussed, please refer to the show notes: https://livelongerworld.substack.com/p/dgems 

    Thanks for listening & if you enjoy the episode, please leave a review on Apple podcasts, support on Patreon, subscribe & share!  

    Stay in good health - Aastha.

  • My guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and children’s pajamas!   

    Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vitamins and minerals leads to accelerated aging. He came up with the Micronutrient triage theory, which says that when nutrient intake is insufficient, the body has a rationing mechanism and favors proteins needed for immediate survival at the expense of protection against future damage.   

    Dr. Bruce Ames is 93 years old and says that he is still exercising and eating healthy greens cooked by his lovely Italian wife! However, he says his cognitive capacity has slowed down (this is why we need rejuvenation therapies, even for the brain: listen to my episode with Dr. Jean Hebert who talks about Brain Aging and his strategy to reverse aging through replacement of the body parts: https://youtu.be/oerGUepWsH8).  

    I am grateful that I had a chance to converse with him on Vitamin D, longevity micronutrients, how micronutrient deficiency can lead to accelerated aging, his take on the science behind reversing aging, and his advice to younger people.   

    This is a shorter episode and I hope you learn more about the importance of micronutrients!  

    All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bames  

    RELATED WRITING: 

    My newsletter post explaining the Micronutrient Triage theory: https://livelongerworld.substack.com/p/bruceames 

    My post on Longevity Foods (Nutrition Doesn't have to be so complicated): https://livelongerworld.substack.com/p/longevityfoods  

    Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium 

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

    Find me on Twitter: https://twitter.com/livelongerworld

    Support on Patreon: https://www.patreon.com/livelongerworld 

    DR. BRUCE AMES LINKS: 

    Website: http://www.bruceames.org/ 

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/

    Patreon page: https://www.patreon.com/livelongerworld

    Podcast All Platforms: https://anchor.fm/livelongerworld

    YouTube: https://www.youtube.com/c/LiveLongerWorld

    Apple Podcasts: https://apple.co/3eZAoAp

    Spotify: https://spoti.fi/3eZB6O5

    Google Podcasts: https://bit.ly/3HN0keG

    Premium Subscriber Benefits: https://www.livelongerworld.com/premium 

    TIMESTAMPS: 

    00:00 Live Longer World 

    00:36 Bruce Ames Intro 

    1:50 Micronutrient triage theory 

    5:40 Micronutrient deficiencies & age acceleration 

    9:10 Vitamin D for healthy aging 

    12:26 CHORI Bar 

    14:46 Measuring micronutrients (blood finger-prick) 

    16:55 Bruce Ames diet 

    18:19 Asthma caused by obesity / bad diet improved by CHORI bar 

    21:21 Dr. Ames lifestyle over the years 

    22:47 Importance of zinc 

    24:15 Nutrition is complicated 

    24:44 Dr. Ames last words & advice for young scientists

    Thanks for listening & if you enjoy the episode, please like, leave a review on Apple podcasts, subscribe & share! Stay in good health - Aastha.

  • My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research.  Dr. Kennedy's lab is working on different small molecules and natural products that could boost longevity. 

    In today's discussion, we spoke about the network concept of the hallmarks of aging, the longevity effects of natural products like Alpha-Ketoglutarate (AKG), Spermidine and Urolithin A, and why combining some of these supplements might not be prudent. We also spoke about comparing the different biomarkers of aging, what we can learn from the longevity of bats, and why basic science is important.  

    All platforms / Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/bkennedy 

    Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium 

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

    Support on Patreon: https://www.patreon.com/livelongerworld 

    DR. BRIAN KENNEDY LINKS: 

    Lab Website: https://medicine.nus.edu.sg/bch/faculty/brian-kennedy/

    Twitter: https://twitter.com/BKennedy_aging 

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

    Instagram: https://www.instagram.com/longevityfuture/

    Patreon page: https://www.patreon.com/livelongerworld

    Podcast All Platforms: https://anchor.fm/livelongerworld

    YouTube: https://www.youtube.com/c/LiveLongerWorld

    Apple Podcasts: https://apple.co/3eZAoAp

    Spotify: https://spoti.fi/3eZB6O5

    Google Podcasts: https://bit.ly/3HN0keG

    Premium Subscriber Benefits: https://www.livelongerworld.com/premium 

    DR. BRIAN KENNEDY RESEARCH DISCUSSED: 

    2020 Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877690/ 

    2020 Aging Biomarkers: From Functional Tests to Multi-Omics Approaches: https://pubmed.ncbi.nlm.nih.gov/32084299/ 

    2021 The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition: https://pubmed.ncbi.nlm.nih.gov/34060628/ 

    2021 Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436907/ 

    2020 The World Goes Bats: Living & Tolerating Viruses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341951/ 

    2021 Yeast as a model organism for aging research: https://www.sciencedirect.com/science/article/pii/B9780128159620000081

    Thanks for watching & if you enjoy the episode, please like, comment, subscribe & share!  Stay in good health - Aastha.

  • My guest today is Dr. Collin Ewald who is a professor at the Health Sciences department at ETH Zurich. His lab focuses on understanding the extracellular matrix (ECM) and how it changes with age. Collin explains the role of the ECM in tissue repair, muscle strength, and overall longevity. In fact, Collin’s lab is also working on establishing the ECM as a biomarker for health and disease risk. So, studying the ECM can indeed tell us a lot about the aging process and ways to intervene.

    Think of the ECM as the environment that surrounds the cell or the proteins secreted from the cell. It holds our organs and tissues in place. You’ve probably heard of collagen protein - it is largely found in the ECM.

    Why is the ECM relevant for longevity research? Turns out, the ECM changes with age. In fact, each cell has a unique ECM and cancer cells can be detected by their ECM composition type! There is also a connection between the ECM and the muscle, and damage to collagen with age results in weakening of our muscles.

    We discuss changes in collagen with age, how sugar impacts collagen, cancer cells & ECM, the overexpression of certain collagens with age, changes in collagen causing muscle impairment with age, and longevity interventions his lab is studying to repair the impairment damage.

    (This podcast can be a little technical, especially in the beginning, so I’d recommend referring to the show notes for better understanding. The video version of the podcast also contains some explanations on the video slide itself.)

    All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/cewald  

    Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium  

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  

    Support on Patreon: https://www.patreon.com/livelongerworld  

    DR. COLLIN EWALD LINKS: 

    Lab Website: https://www.ewaldlab.com/ 

    Twitter: https://twitter.com/CollinEwald   

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/ 

    Twitter: https://twitter.com/livelongerworld 

    Newsletter: https://livelongerworld.substack.com/ 

    Instagram: https://www.instagram.com/longevityfuture/ 

    Patreon page: https://www.patreon.com/livelongerworld 

    Podcast All Platforms: https://anchor.fm/livelongerworld 

    YouTube: https://www.youtube.com/c/LiveLongerWorld 

    Apple Podcasts: https://apple.co/3eZAoAp 

    Spotify: https://spoti.fi/3eZB6O5 

    Google Podcasts: https://bit.ly/3HN0keG 

    Premium Subscriber Benefits: https://www.livelongerworld.com/premium

    TIMESTAMPS:

    Episode Page: https://livelongerworld.substack.com/p/cewald 

    YouTube: https://youtu.be/r1Y5wGSqKWA

    DR. COLLIN EWALD RESEARCH: 

    The Matrisome during Aging and Longevity: https://www.karger.com/Article/FullText/504295 

    Collagen overexpression increasing lifespan: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352135/ 

    Youthful and age‐related matreotypes predict drugs promoting longevity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441316/ 

    Doubling life near death: https://elifesciences.org/digests/71335/doubling-life-near-death

    Thanks for watching & if you enjoy the episode, please like, comment, leave a review, subscribe & share!  Stay in good health - Aastha.

  • My guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. 

    Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the animals shared blood and environment. The old mice became rejuvenated & younger. They’ve also pioneered a process called the Neutral Blood Exchange or Therapeutic Blood Exchange, through which dilution of old blood plasma can lead to true rejuvenation in the brain & other tissues of mice to a younger state!!   

    Further, we touch upon Irina's work showing how decreased Oxytocin levels with age contributes to poor muscle function. Their research is incredibly exciting and we discuss all about it in today’s episode.  

    Episode Show Notes: https://livelongerworld.substack.com/p/rejuvenation-via-plasma-dilution

    Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium 

    Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

    DR. CONBOY LINKS: Berkeley Lab: https://conboylab.berkeley.edu/  

    2021 Paper Plasma Dilution Improves Cognition and attenuates neuroinflammation in old mice: https://pubmed.ncbi.nlm.nih.gov/33191466/  

    2020 Paper Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288913/  

    2014 Paper Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration: https://www.nature.com/articles/ncomms5082  

    LIVE LONGER WORLD LINKS: 

    Website: https://www.livelongerworld.com/

    Twitter: https://twitter.com/livelongerworld

    Newsletter: https://livelongerworld.substack.com/

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    Google Podcasts: https://bit.ly/3HN0keG

    TIMESTAMPS: 

    00:00 Live Longer World Intro 

    00:35 Irina & Michael Conboy Intro 

    1:08 Aging is slowdown in our repair machinery 

    2:55 Naked Mole Rats not extreme model for longevity 

    5:37 Heterochronic Parabiosis 

    16:00 Young Blood to Old Blood Exchange 

    19:19 Rejuvenation via Neutral Blood Exchange (NBE) 

    22:56 Old Blood Degenerates Young Mice 

    25:29 Rejuvenation Effects on Brain, Liver, Muscle through NBE 

    27:16 How long do effects of NBE last? 

    30:15 How is NBE working mechanistically? 2 waves of rejuvenation 

    33:38 Inhibiting TGF-beta & Increasing Oxytocin is rejuvenative 

    38:12 NBE vs. Senolytics 

    40:53 Unanswered Questions on NBE 

    43:13 Oxytocin & Muscle Functioning; Notch Signaling 

    48:12 Chickens & Ravens as Pets!  

    Thanks for listening & if you enjoy the episode, please like, subscribe & share! Stay in good health - Aastha.

  • Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. 

    Dr. Barzilai’s research interests are in the biology and genetics of aging, so he has done extensive work studying centenarians and supercentenarians some of which he discusses in today’s episode and also in his book Age Later.  

    He is currently leading an international effort to approve drugs that can target aging. Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that multi-morbidities of aging can be delayed by metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans.  

    In today's episode, we discuss centenarian longevity genes, what makes centenarians live so long and the role of growth hormones in longevity. We also dive into metformin's healthspan benefits for longevity, metformin & COVID, if metformin blunts muscle mass and causes hypoglycemia, and metformin dosage. 

    Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/snbarzilai

    FOLLOW NIR BARZILAI:  

    Profile: https://einsteinmed.edu/faculty/484/nir-barzilai/  

    Twitter: https://twitter.com/NirBarzilaiMD  

    Book: https://us.macmillan.com/books/9781250230867  

    FOLLOW LIVE LONGER WORLD:  

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