Afleveringen
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They're new, they're weird, and we don't use them very much (or at all), but that won't stop your favourite ID:IOTS sounding off on these novel tetracyclines!
In this episode we discuss: An overview of the 3 drugs, including spectrum & penetrance; pharmacokinetics; EUCAST breakpoints; resistance mechanisms; and the recommendations for use in the IDSA DTR Gram Negative guidelines 2024.
Prep notes for the episode here.
Got a question? Use the new 'send us a text' link in the episode description!Send us a text
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In which Jame talks about the rationale for IVOS, evidence base for the pros and cons, and then finishes by giving the UK oral switch criteria an absolute rinsing.
Prep notes available here.Send us a text
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Zijn er afleveringen die ontbreken?
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Moraxella means more moronic puns from Jame&Callum. A short episode for some short rods. Listen to hear about this coccobacillus, how to identify it in the lab and what sort of clinical syndromes it causes.
Show note for this episode hereSend us a text
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Join Jame and Callum as they discuss this paper which examines where these new antibiotics are going, and why they aren't widely available.
Notes for this episode hereSend us a text
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Join Jame and Callum on this episode about the ultimate 4 rings of power: Tetracyclines. The swiss army knife of antibiotics. We talk through the history, uses, mechanism, PK/PD and resistance.
Become a pharmacophile as you learn something about pharmacophores.
Shows notes for this episode hereSend us a text
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Jame and Callum are joined by Lee John and Ella for this episode around the arch-villain of atypical pneumonia and the bogeyman of every spa. Yes Legionella pneumophila (and friends) are addressed in depth whilst this podcast is aerosolised around the world.
Show notes for this episode hereSend us a text
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You'll be whooping with knowledge after listening to this one. Come hear all about Bordetella species. From pertussis to kennel cough you'll hear it all.
Show notes for this episode hereSend us a text
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The Spring Meeting of the British Infection Assocation is a must for UK infection trainees; In this week's episode Callum summarises for Jame (who was there, but didn't take any notes) the main learning points from the meeting.
Show notes for this episode here
BIA membership is FREE to UK infection trainees, reasonably priced for everyone else, and paid memberships come with online access to the Journal of Infection! Sign up today at https://www.britishinfection.org/join.Send us a text
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Jame was there but Callum wasn't! The British Society for Antimicrobial Chemotherapy have several conferences throughout the year, including a Spring meeting with their AGM. But what topics were discussed, I hear you wonder? WELL WONDER NO MORE: Jame'll take you through it!
Notes for this episode hereSend us a text
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In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, finishes educating Callum and Jame (mostly Callum) on the concept of Microbiotoxicity!
This episode is part 2 of 2. Here we discuss:
- What is microbiotoxicity?
- Risk factors for microbiotoxicity
- Which antibiotics are associated with microbiotoxicity?
- Mitigating microbiotoxicity
https://www.researchgate.net/profile/Anastasia-Theodosiou
https://x.com/doctoranastasiaSend us a text
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Questions, comments, suggestions to [email protected] or on X/Threads @IDiots_pod
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In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, returns to talk about her favourite subject!
This episode is part 1 of 2. Here we discuss:
- What is the microbiome
- Viewing the microbiome as an organ system
- The microbiome's association with disease
- How we study the microbiome
Stay tuned for part 2 (in 1-2 weeks depending on editing), when we talk about the effect of medicine on the microbiome, microbiotoxicity, and what you can do to keep your patients' microbiomes in tip top shape!
https://www.researchgate.net/profile/Anastasia-Theodosiou
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Join us for this special 80th episode celebrating Jame's favourite trial.
https://www.nejm.org/doi/full/10.1056/NEJMoa1808312
Prep notes (including the images referred to in the poem) here.
Special thanks to the Wikiguidelines Endocarditis crew for their work summarising the evidence this poem was based on.Send us a text
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Presenting: More on Penicillin-Binding-Proteins than you realistically ever need to know!
What is the difference between Gram positive and negative bacteria's cell walls?What is a Penicillin Binding Protein (PBP)?Why are they called PBPs?What do PBPs do?What makes MRSA resistant to (most) beta-lactams?These any many more questions answered!
Notion page here - you'll need it for this one, check it out!Send us a text
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One PK table to rule them all
One table to find them
One table to bring them all
And in the darkness blind them…
…with awesome antibiotic PK facts you can use to bedazzle your friends and enemies alike!
Prep notes here.Send us a text
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Questions, comments, suggestions to [email protected] or on X/Threads @IDiots_pod
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The last Pharmacokinetics episode had finally been …Excreted!
This episode covers the ‘drug out’ bit of pharmacokinetics, including things such as:
-What is clearance?
-how to calculate half life
and
-doesn’t everything leave through the kidneys anyway? (That is sort of true, also shut up).
Check out our prep notes (including for this episode) here.Send us a text
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Questions, comments, suggestions to [email protected] or on X/Threads @IDiots_pod
Prep notes for completed episodes can be found here (Not all episodes have prep notes).
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It's the second Pharmacokinetics episode you never knew you wanted! Let’s talk about how antibiotics are distributed around the body once absorbed, using the examples of Amoxicillin and CallumShutUpicillin (listen to episode for clarification).
What exactly is the volume of distribution? Want a handy reference for the plasma protein binding of various antimicrobials? Then this is the episode for you! Check out our prep notes (including for this episode) here.Send us a text
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It's the Pharmacokinetics episode you never knew you wanted! Callum didn't know either, but never mind that let's talk about how antibiotics are absorbed, and how we can use that to improve our use of them in clinical practice.
Want ammunition for that oral switch? Got someone who's doubting oral antibiotics' effectiveness? Then this is the episode for you! Check out our prep notes (including for this episode) here.Send us a text
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In this final episode of the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the (mostly historical) pathogen Burkholderia mallei, causative agent of Glanders.
We did it. We got to the end.
Nonfermentors... Nobbled.Send us a text
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Post-publication, Callum and Jame give a little extra information on the SABATO trial in its final form compared to it's pre-publication state.
Final article here:
Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial, Kaasch, Achim J Valiente, Adoración et al. Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9.
PMID: 38244557.
https://doi.org/10.1016/S1473-3099(23)00756-9Send us a text
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JOURNAL CLUB, YO, IT’S A SABATO!!!
Join Jame and Callum as we travel back in time to when we recorded this deep dive into the SABATO trial pre-print, now peer-reviewed and published in the Lancet ID!
In the next episode we'll give a little update as to how the final article differs from the preprint (not much).
We also talked about in our FIS Highlights Episode 3.
We loved this trial and we hope you’ll all give it a read, it’s well worth it!
Article here:
Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial, Kaasch, Achim J Valiente, Adoración et al. Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9.
PMID: 38244557.
https://doi.org/10.1016/S1473-3099(23)00756-9Send us a text
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