Afleveringen
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Dr. Thomas Seyfried challenges the existing paradigm that says cancer is a genetic disease. He says that instead cancer is caused by damage to the mitochondria. Understanding this completely overturns the management and prevention of cancer.
He is a Professor of biology, genetics, and biochemistry at Boston College. He has over 150 peer-reviewed publications and is also the author of books such as, âCancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancerâ.
WE DISCUSS:
- Why cancer is not a genetic disease
- Why cancer is a metabolic disease originating from damage to the mitochondria
- How metabolic therapy, management of glucose and glutamine, can be used to manage cancer
- His December 2024 paper outlining a proposal for ketogenic metabolic therapy in glioblastoma
Episode Show Notes: https://livelongerworld.com/p/tseyfriedFind me: https://x.com/aasthajs
TIMESTAMPS: 0:00 Cancer is not a genetic disease
5:04 Origins of somatic mutation theory of cancer
8:04 Mitochondrial damage causes cancer
13:42 Is mitochondrial dysfunction involved in every cancer
16:14 Mitochondria in cancer cells ferment
21:52 Target glucose and glutamine to manage cancer
28:51 Hyperbaric Oxygen therapy for cancer
31:04 December 2024 study: Role of glutamine in cancer
33:35 Can metabolic therapy be done at any stage of cancer
36:44 Combine chemotherapy with metabolic therapy
38:05 Drugs to target glutamine
40:30 People will say âI want metabolic therapyâ
44:04 âFailure to understand biologyâ
47:48 National Cancer Instituteâs take on Dr. Seyfriedâs theory
49:34 Why does Peter Attia think cancer is a genetic disease
53:09 âI think about this 24/7; weâre right!â
55:56 Glioblastoma treatment protocol study
59:22 Resistance to breakthrough ideas in science
1:01:40 Radiation fuels cancer!
1:04:52 Current standard of care is responsible for poor survival rate in glioblastoma
1:07:14 Metabolic therapy for epilepsy, Parkinsonâs, Alzheimerâs
1:12:22 How to prevent cancer
1:13:49 Young, healthy individuals in their 20s, 30s with cancer
1:15:05 Resources on following metabolic therapy
1:17:43 How to support Dr. Seyfriedâs research
1:18:51 New cancer questions Dr. Seyfried is researching
1:21:32 Closing thoughtsAASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. THOMAS SEYFRIED: X: https://x.com/tnseyfriedBio page: https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.htmlCancer as a Metabolic disease book: https://amzn.to/3WBF31D
RELATED EPISODES:
The Cancer-Diet Connection & Otto Warburg - Nobel Prize Scientist under Hitler | Sam Apple, Author of Ravenous
Modified Ketogenic Diet for Optimal Health & Exercise | Dr. Dominic D'Agostino
Ketogenic Diet for Brain Health & Longevity | Dr. Dominic D'Agostino
The Evolutionary Theory of Cancer | Charley Lineweaever
Bioelectricity and Cancer w/ Michael Levin
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Denis Noble and Michael Levin - two great minds in biology come together on Live Longer World.Denis Noble is a renowned biologist and pioneer in systems biology, known for his groundbreaking work on the electrical activity of the heart and his influential contributions to the understanding of biological systems. Denis is an advocate for taking a systems integrative approach to biology, as opposed to the reductionist gene-centric view that has dominated the field due to Neo-Darwinism.
The gene-centric view has failed us in advancing progress on many diseases, and we need to now take a systems based approach focused on functional networks within biological systems.
Michael Levin is an American developmental and synthetic biologist at Tufts University, where he is the Vannevar Bush Distinguished Professor. His research is focused on bioelectricity and he is my co-host for this podcast.We discuss:- DNA is not the blueprint of life- Why biologyâs reductionist approach is flawed- The errors in Neo-Darwinism- Epigenetic inheritance- How to advance the cure of diseasesEpisode Show Notes: https://livelongerworld.com/p/dnobleFind me: https://x.com/aasthajs TIMESTAMPS:0:00 Denis as Mike Levinâs hero
0:10 Denisâs journey to systems biology; cell voltage is a global property of the cell
3:45 Advice to young researchers pursuing systems biology
7:00 âAbsolutely everything is wrong with Neo-Darwinismâ
14:10 Epigenetic inheritance
19:12 Genetic vs. other information used by organisms
23:48 Biology textbooks have to expand beyond DNA in 50 years
25:03 Epigenetic processes are ubiquitous
28:58 If not DNA, what is the blueprint of life
36:15 Rewriting biology textbooks is fundamental
39:57 âA lot of time has been wastedâ (in biology)
46:52 Darwin on the âOrigin of Speciesâ
55:38 âUnfortunate that Philosophy and science have divergedâ
1:00:31 Importance of Functional networks; DNA does not predict disease AASTHA, LIVE LONGER WORLD:Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/LINKS:Michael Levin: https://twitter.com/drmichaellevinDenis's book Dance to the Tune of Life: https://a.co/d/3hvh5JWEpisode Show Notes: https://livelongerworld.com/p/dnoble
Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm
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Zijn er afleveringen die ontbreken?
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This interview is part of my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity.Dr. Mustafa Djamgoz was one of the first people to study the role of ion channels and bioelectricity in cancer, which he initially documented in a 1995 paper. His research showed that there was an uptake in voltage-gated sodium channels in all types of cancer metastasis, except prostate cancer, highlighting the significant role of studying ion channels in cancer.Simply put, the spread of cancer cells is linked to increased activity in sodium ion channels, which regulate electrical currents in our cells. Episode Show Notes: https://livelongerworld.com/p/mdjamgozFind me: https://x.com/aasthajs Background on the bioelectricity series & 1st episode with Dr. Richard Nuccitelli: https://youtu.be/DtUqOwTRvz0?si=3OJryM0yJjzfQtfoTIMESTAMPS:0:00 Playing with radios at age 17 to bioelectricity cancer research4:31 Advice for young people entering bioelectricity9:02 Biophysics and Cancer neuroscience 17:55 Role of bioelectricity in cancer27:02 Cancer metastasis and ion channels28:49 Sodium channel uptake and cancer invasiveness36:59 Ranolazine, potential anti-metastatic drug43:45 Funding for bioelectricity cancer research50:21 Advice for cancer patientsAASTHA, LIVE LONGER WORLD:Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/
Instagram: https://www.instagram.com/aasthajs/Michael Levin: https://twitter.com/drmichaellevinMustafa's publications: https://profiles.imperial.ac.uk/m.djamgoz/publicationsMustafa's book Beat Cancer: https://www.amazon.com/Beat-Cancer-Regain-Control-Health-ebook/dp/B00CU8QBASEpisode Show Notes: https://livelongerworld.com/p/djamgozMichael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm
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Dr. Alfonso Martinez Arias is a development biologist and the author of the book The Master Builder: How the New Science of the Cell Is Rewriting the Story of Life. He also co-authored the biology textbook Principles of Development, which was awarded the Royal Society of Biology book prize. Episode Show Notes: https://livelongerworld.com/p/aarias OVERVIEW: Each of our cells has the same DNA. Yet they somehow differentiate into different body parts - eyes, ears, skin, and so on. There is no information in the DNA that tells our cells what to be. How then do they do it? This is just one example of how contrary to what many might think, DNA does not explain every problem state in biology. Biology has placed too much emphasis on our genes, trying to explain every disease state using genes, when the answer might not reside with them. What if answers to these questions lies with cells? Even though Dr. Martinez started off as a geneticist, he decided to pivot to understand the properties of cells better. By understanding our cells better, we can make further progress in understanding disease, longevity, and development.
Towards the end, we also talk about Alfonso's fascinating work on gastruloids which are a model to unravel the mysteries of embryonic development, and understand how humans are formed.This conversation is about the cellâs eye view of biology, and how the gene's eye view of biology might have mislead us. We also talk about why the popular selfish gene theory espoused by Richard Dawkins is incomplete. Looking beyond genes is instrumental to making progress in longevity.
Episode Show Notes: https://livelongerworld.com/p/aarias Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Intro1:15 DNA does not make us unique5:28 Cells use our genes10:42 âWe have overstretched what genes can explainâ15:41 Relation between genes and cells20:28 What about the role of epigenetics?22:42 Cells use mechanical and chemical signals27:34 Thoughts on bioelectricity and Michael Levin32:28 Emergence of cells38:10 Importance of biophysics; What is life?42:32 Is cancer when cells lose control?47:58 Richard Dawkinsâ Selfish Gene is Incomplete54:11 But what if genes control development?57:29 How to complete the selfish gene view?1:02:05 Cellâs eye view of biology1:04:48 Understanding embryonic development; gastruloids1:18:15 Questions Dr. Alfonso is pursuing1:19:47 Thoughts from FeynmanAASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. ALFONSO MARTINEZ ARIAS: Master Builder book: https://www.amazon.com/Master-Builder-Science-Rewriting-Story/dp/1541603273 X: https://x.com/AMartinezArias Bio page: https://www.icrea.cat/Web/ScientificStaff/alfonso-martinez-arias-352001
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The following is a fascinating interview with Dr. Charley Lineweaver, who worked with Paul Davies on his work on cancer which we discuss. Episode Show Notes: https://livelongerworld.com/p/clineweaverTopics include: - the evolutionary and atavistic theory of cancer- the incorrectness of the somatic mutation theory of cancer- a novel take on attacking the weakness of cancer- how embryogenesis could be viewed as cells reverting to old memory- the origins of multicellularity- âCancer cannot do anything newâ The atavistic theory of cancer states that cancer cells revert to an old memory they have from billions of years, but forget the new memory. The old memory pertains to constant cell proliferation, which happened as single-celled creatures, and in fact in embryogenesis as well. The new memory pertains to regulating cell proliferation and cells knowing when to stop cellular division. In cancer, it seems like cells forget this new memory and revert to the old memory.This theory has many interesting explanations and predictions which we dive into in the conversation. Enjoy!Episode Show Notes: https://livelongerworld.com/p/clineweaverFind me: https://x.com/aasthajs TIMESTAMPS:0:00 Background in astrobiology 1:53 Evolutionary theory of cancer 6:22 Atavistic model: Cancer cells go back to âoriginal stateâ 9:50 Atavistic theory vs. Cancer 14:44 Somatic Mutation Theory of Cancer is Wrong 22:36 Disagreement with Mike Levinâs work 24:17 Attack the weakness of cancer 27:45 Vaccine for cancer 38:08 Wound healing and cancer 41:23 Why new genes are more susceptible to damage 45:26 Origins of multicellularity 48:49 Predictions of Atavistic model 53:45 Cancer cells spread 56:52 Cell proliferation, Cancer, Hayflick limit 58:54 Doctors are not trained in evolutionAASTHA, LIVE LONGER WORLD:Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/
Instagram: https://www.instagram.com/aasthajs/DR. CHARLEY LINEWEAVER: Website: https://researchers.anu.edu.au/researchers/lineweaver-chPapers referenced:- Cancer progression as a series of atavistic reversions: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860064/
- Targeting cancer's weaknesses, not its strengths: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282648/
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This is the third in my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity.Ken Robinson has a long list of accomplishments in the bioelectricity field, covering the role of electric fields in guiding cell migration and more generally the function of electrogenic epithelia in embryogenesis. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his time in Lionel Jaffe's lab.Episode Show Notes: https://livelongerworld.com/p/krobinsonFind me: https://x.com/aasthajs Background on the bioelectricity series & 1st episode with Dr. Richard Nuccitelli: https://www.livelongerworld.com/p/rnuccitelliTIMESTAMPS:0:00 Intro
0:38 Kenâs background - From physics to bioelectricity
6:10 Bioelectricity in the era of the âgenetic codeâ
10:27 Kenâs first experiments in ion movement using light
23:25 Proton pump and its significance
26:07 Neurons respond to electrical signals
36:26 Working in Lionel Jaffeâs lab
47:39 Mike Levin as an undergrad
48:49 Membrane potential left-right asymmetry in cells
52:59 Epithelia is powerfully electrogenic
57:49 Advances for bioelectricity
59:27 Underrated people in the fieldAASTHA, LIVE LONGER WORLD:Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Michael Levin: https://twitter.com/drmichaellevinMike's bibliography of bioelectricity: https://thoughtforms.life/my-reference-lists-whole-endnote-library-and-bibliography-on-bioelectromagnetics/Episode Show Notes: https://livelongerworld.com/p/krobinsonMichael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm
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This is the second of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Min Zhao's work is focused on the role of ion currents and applied electric fields in cell migration and wound repair.Episode Show Notes: https://livelongerworld.com/p/mzhaoFind me: https://x.com/aasthajs Background on the bioelectricity series & 1st episode with Dr. Richard Nuccitelli: https://youtu.be/DtUqOwTRvz0?si=3OJryM0yJjzfQtfoTIMESTAMPS:0:00 Minâs background from trauma surgery to bioelectricity5:14 Bioelectricity in wound healing13:51 Potential and challenges of bioelectricity in wound healing21:40 Minâs take on Robert Beckerâs work24:53 Scientists in the field Min drew got inspired by29:36 The era before Lionel Jaffe32:39 Experiments in wound healing using bioelectricity45:43 Minâs current explorationsAASTHA, LIVE LONGER WORLD:Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Michael Levin: https://twitter.com/drmichaellevinMin Zhao: https://health.ucdavis.edu/dermatology/faculty/zhao.htmlEpisode Show Notes: https://livelongerworld.com/p/mzhaoMichael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm
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Stephanie Seneff is the pioneer in raising concerns around glyphosate, a chemical and active ingredient in RoundUp and other pesticides, which has practically infiltrated our food system, water bodies, and soil. Glyphosate has been linked to several diseases including liver disease, autoimmunity, neurological disorders, reproductive issues, microbiome problems, and more.Dr. Stephanie Seneff has spent 10+ years researching glyphosateâs harmful impact on our health, and documented her findings in her book Toxic Legacy: How the Weedkiller Glyphosate is Destroying our Health and the Environment.More recently, Stephanie has been doing research on deuterium (a hydrogen isotope in the body) and how glyphosate can cause an excess of deuterium, potentially leading to cancer and other health consequences. Glyphosate is affecting each one of us. Itâs worth paying attention to this toxic chemical.Episode Show Notes: https://livelongerworld.com/p/sseneffFind me (Aastha) on X: https://x.com/aasthajsDR. STEPHANIE SENEFF LINKS:Website: https://stephanieseneff.net/X: https://x.com/stephanieseneffBook: https://www.amazon.com/Toxic-Legacy-Stephanie-Seneff/dp/1603589295/AASTHA, LIVE LONGER WORLD:X: https://x.com/aasthajsNewsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/Airchat: https://www.getairchat.com/aasthajsTIMESTAMPS:0:00 Autism in children, vaccines, glyphosate2:30 Aluminum and fluoride in water3:47 Glyphosate in our food and its toxicity6:05 Celiacâs link to glyphosate8:25 Glyphosate impacting collagen in our bodies12:55 Soil regeneration after glyphosate15:24 Breaking down glyphosate in our waterways16:36 Glyphosate causing sulfate deficiency; cruciferous veggies18:43 Sulfate powers bioelectricity in our cells; Gerald Pollack21:23 Avoid sunscreen?22:25 Deuterium and its toxicity25:20 How Stephanie started looking at Deuterium26:36 Low deuterium water good for health?29:25 Excess deuterium causing cancer30:52 Stephanieâs wild theory on curing cancer35:19 What else causes increase in deuterium35:38 Glyphosate in rain water36:25 PSCSK9 inhibitors harmful with glyphosate38:49 Solutions to avoid glyphosate42:23 U.S. stopped Mexico banning glyphosateEpisode Show Notes: https://livelongerworld.com/p/sseneff
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This is the first of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity.
Richard Nuccitelli is a legend, having invented (with Lionel Jaffe, in 1974) the Vibrating Probe - a technique that allowed the non-invasive sensing of ion currents around living tissues. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his current clinical work on the bioelectrics of cancer.Episode Show Notes: https://livelongerworld.com/p/rnuccitelli
Find me: https://twitter.com/aasthajsBACKGROUND:In 2022, I interviewed Dr. Michael Levin on his work on bioelectricity in cells and how that has the potential to solve cancer and aging. Since then, Mike has also appeared on Lex Fridman and many other podcasts talking about his revolutionary work.Amongst all the podcasts I did, Mikeâs work struck me as profound yet underappreciated. The field of biology has focused on the DNA and the relevance of the electric currents in our cells is not appreciated. Yes, the electrical energy powering our cells is what keeps us alive! Earlier this year, I decided to dive deeper into bioelectricity. Iâm starting by exploring the history of the field in conjunction with Michael Levin. Weâre doing a series of interviews talking to scientists in the field to understand the origins of the field, bottlenecks, progress so far, and what the future could look like.Today's interview is the first in the series with Dr. Richard Nuccitelli.TIMESTAMPS:0:00 Intro to History of Bioelectricity Series1:09 How Rich got interested in bioelectricity4:34 Bioelectrics didn't make it to biology literature7:55 Vibrating probe use cases10:20 Bioelectrics in 1970s13:37 Why is bioelectrics underrated?22:50 Field progression29:02 Ultra high voltage in treating cancer39:00 Understanding significance of bioelectrics from 1900s44:40 Working with Lionel Jaffe50:27 How Mike entered bioelectrics54:02 Criticism received by bioelectrics?57:04 Missing technology to advance bioelectrics1:00:52 Electrical patterns in cells with age1:03:12 Image of electrics in organismsAASTHA, LIVE LONGER WORLD:Twitter: https://twitter.com/aasthajsNewsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/Airchat: https://www.getairchat.com/aasthajsMichael Levin: https://twitter.com/drmichaellevinRichard Nuccitelli: https://www.linkedin.com/in/nuccitelli/ Episode Show Notes: https://livelongerworld.com/p/rnuccitelli
Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm
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Dr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin.We discuss:- The history of the FDA,- The trial of Avastin which got FDA approval in 2008 and revoked in 2011- FDA's funding mechanisms- FDA ties to big pharma- What can be improved about the FDA and the criticisms it receives
Episode Show Notes: https://livelongerworld.com/p/msekeresTIMESTAMPS:0:00 Surprising finding about the FDA2:38 Why did the FDA get established in 1938?11:48 1962 turning point in the FDA & Thalidomide19:57 Kennedyâs efficacy act on drugs approval25:40 FDAâs accelerated approval; HIV & AIDS33:23 Avastin breast cancer drug controversy41:13 Why was Avastin trial contentious?45:23 Genentechâs argument50:00 Media reaction53:21 FDA funded by big pharma56:39 FDA vs. patient activist groups59:50 Opioid crisis1:03:30 Does the FDA go against advisory committee?CONNECT WITH AASTHA, LIVE LONGER WORLD:Twitter: https://twitter.com/aasthajsNewsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/Airchat: https://www.getairchat.com/aasthajsDR. MIKKAEL SEKERES LINKS:Website: https://www.mikkaelsekeres.com/Twitter: https://twitter.com/MikkaelSekeres
Book: https://www.amazon.com/Drugs-FDA-Safety-Efficacy-Publics/dp/0262047314If you enjoyed the episode, please share it and leave a rating. Best, Aastha.
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Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In todayâs conversation we discussed menopause and itâs effect on womenâs health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer.
Episode Show Notes: https://livelongerworld.com/p/jgarrison
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.com/Find me (Aastha) on Twitter: https://twitter.com/aasthajs
DR. JENNIFER GARRISON LINKS:Lab: http://garrisonlab.com/ Donate to her research: https://gcrle.org/CONNECT WITH AASTHA, LIVE LONGER WORLD:Twitter: https://twitter.com/aasthajsNewsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/Airchat: https://www.getairchat.com/aasthajs
TIMESTAMPS:00:00 Intro1:38 Jennifer Garrison Intro2:32 Ovarian aging & health risks5:23 Progression of Ovarian aging8:49 Menopause and negative health effects10:34 Hypothalamus & Mind body communication14:40 Reproductive & Equality Initiatives18:21 Biological Clock for Reproductive aging20:20 Tweaking hormonal cues22:07 Number of eggs vs. Quality of eggs25:00 Genetics in ovarian aging26:21 Understanding family history27:39 Evolutionary benefit to Menopause?32:33 Hormone Replacement Therapy (HRT) & its benefits38:28 Narrow window for HRT40:08 Perimenopause42:56 Womenâs health funding45:14 Average age girls start menstruating is declining49:10 PCOS52:42 Athletes and irregular cycles56:36 Individualized menopause symptoms1:00:38 Exercise and ovarian aging1:02:00 Support Jennifer's work
Episode Show Notes: https://livelongerworld.com/p/jgarrisonPOPULAR EPSIODES:- Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA- Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg- Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8- Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8- Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member.
Aging is universal. Let's unite in this fight.Stay in good health - Aastha.
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Dr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity.
Episode Show Notes: https://livelongerworld.substack.com/p/gwestFind the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/aasthajs
DR. GEOFFREY WEST LINKS:Profile: https://www.santafe.edu/people/profile/geoffrey-westBook: https://amzn.to/3Xtl7wUCONNECT WITH AASTHA, LIVE LONGER WORLD:
Newsletter: https://livelongerworld.substack.com/
Twitter: â https://twitter.com/aasthajs
Instagram: https://www.instagram.com/aasthajs/
Airchat: https://www.getairchat.com/aasthajs
TIMESTAMPS:1:35 Context on Dr. West's book Scale9:00 Networks in biology & cities22:50 Scaling laws in longevity
32:33 Upper limit to human age?
39:08 Quantifying Caloric restriction
41:52 Metabolism & Body temperature
49:05 Scaling laws in age-related damage
56:35 Scaling body sizes across species
1:01:38 Scaling laws in drug dosage (LSD & Elephants)
1:11:06 Drug dosage in children (Tylenol & babies)
1:13:44 Vaccine dosage scaling laws
1:17:51 Sleep & Aging in different organisms
1:31:22 Early stimulation for child development
1:36:35 Fasting, meal frequency & digestive time
1:39:10 Sleep demands with work & physical activity
1:43:40: Scaling laws in cities, companies & universities
2:02:00 Outro
POPULAR EPSIODES:
Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA
Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg
Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8
Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8
Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member.Aging is universal. Let's unite in this fight.Stay in good health - Aastha.
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All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad
Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions!
There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austadâs work focuses on what long-lived animal species can teach us about living longer and healthier lives. His lab works on exotic species, like clams that live more than 500 years, and hydra that donât age at all, in order to discover aging treatments. He also tries to uncover the mysteries around why men and women respond differently to longevity therapeutics.
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/aasthajz
DR. STEVEN AUSTAD LINKS:
Website: https://www.stevenaustad.com/
Twitter: https://twitter.com/StevenAustad
Faculty page: https://www.uab.edu/cas/biology/people/faculty/steven-n-austad
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/aasthajz
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/aasthajz/
TIMESTAMPS:
0:00 Training lions
7:15 Learning from Long-lived species
9:55 Bowhead whales live 200 years
12:55 House sparrows & longevity
14:40 Study "successful" animals
18:10 Naked Mole Rats
20:45 What do bowhead whales die from?
26:05 Why do ocean animals live longest?
31:05 Beyond Caloric Restriction
36:00 Intermittent Fasting & Circadian Rhythm
42:40 Caloric Restriction for Healthy people?
46:24 Will coffee shorten your life?
49:43 The Blue Zone Myth
55:50 Young Blood, I can't get you of out my Mind
1:00:26 Hormones & Health (Growth Hormones for longevity?)
1:05:18 Sex differences in longevity
Episode Show Notes: https://livelongerworld.substack.com/p/saustad
POPULAR EPSIODES:
- Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA
- Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg
- Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8
- Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8
- Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo
Thanks for watching & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
-
All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2
Dr. Dom DâAgostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition.
This is Part 2 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the ketogenic diet for exercise performance, keto for women & children, Dom's diet & supplement routine + more! Hope you enjoy the episode!
Part 1 with Dom on Ketogenic diets for Brain Health and Longevity: https://livelongerworld.substack.com/p/dom1
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/aasthajz
SUPPORT LIVE LONGER WORLD:
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
DOM D'AGOSTINO LINKS:
KetoNutrition: https://ketonutrition.org/
Website: https://linktr.ee/Domdagostino
Twitter: https://twitter.com/DominicDAgosti2
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/aasthajz
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/aasthajz/
TIMESTAMPS:
0:00 Ketogenic diet for muscle performance
0:50 Domâs supplements & modified keto diet
3:20 Keto, NAD+, NMN 7:12 Biomarkers tracked by Dom
9:30 LDL, Triglycerides, Fatty Foods & Keto diet
14:15 Domâs routine & supplements
18:09 Melatonin benefits for anti-cancer & antioxidant
22:37 Ketogenic diet for women
30:55 Ketogenic diet for children
32:48 Genetic aspect to keto diet?
38:32 Metformin for suppressing cancer
46:30 Ketogenic diet & Alzheimerâs
54:40 Exercise for mental health
55:53 Keto for exercise performance & bodybuilding
59:32 Endogenous metabolite & psychedelics
1:09:05 Connect with me (Aastha)
Episode Show Notes: https://livelongerworld.substack.com/p/dom2
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. If you like the podcast, please leave a review on Apple podcasts.
Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
-
All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1
Dr. Dom DâAgostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition.
This is Part 1 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the history of ketogenic diets, keto for brain health and neuroprotective seizures, keto for longevity benefits, weight training, caloric restriction and more. Hope you enjoy the episode!
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/livelongerworld
SUPPORT LIVE LONGER WORLD:
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
DOM D'AGOSTINO LINKS:
KetoNutrition: https://ketonutrition.org/
Website: https://linktr.ee/Domdagostino
Twitter: https://twitter.com/DominicDAgosti2
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
TIMESTAMPS:
0:00 Ketogenic diet is not optimal for everyone
0:56 Dom DâAgostino Intro
1:29 Plant-based ketogenic diet
3:20 Ketogenic diet & brain protection against seizures
16:40 Ketone Esters & Salts
19:29 Does the brain need glucose?
21:37 Intermittent Ketosis & Fasting Mimicking Diet
25:17 Cyclic Ketogenic diet for longevity
28:40 Devices for tracking ketosis
30:30 Ketogenic diet for longevity vs. Caloric restriction
37:50 Keto diet for cancer prevention
41:57 Keto diet, Insulin pathway, and glucose
46:50 Time restricted eating benefits
50:17 Dom vs. Layne Norton on Joe Rogan podcast
51:40 Muscle for longevity (especially for women)
56:10 Support Live Longer World
Episode Show Notes: https://livelongerworld.substack.com/p/dom1
Thanks for watching & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.
Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
-
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple
Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection.
Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Naziâs and he was the first person to put the metabolic story of cancer on the map. The famous âWarburg Effectâ that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him.
It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation!
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/livelongerworld
SUPPORT LIVE LONGER WORLD:
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
SAM APPLE LINKS:
Ravenous book: https://amzn.to/3yT9qpd
Website: http://www.samapple.com/
Twitter: https://twitter.com/Sam_Apple1
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
TIMESTAMPS:
0:00 Cancer as a disease of modern societies
1:27 Otto Warburg & the Cancer-Metabolic Connection
2:27 Warburgâs research on respiration
4:02 Why was cancer skyrocketing in Western societies?
9:17 Warburg Effect: Warburgâs research on cancer cells
15:00 Why do cancer cells take up so much glucose?
17:44 Cancer-Diet Connection
21:44 Cancer, Ketogenic diets & Fasting
23:43 Hibernation of the metabolic story of cancer
27:20 Hitlerâs connection with cancer
30:07 Warburgâs arrogance
31:51 Why does cancer need glucose?
38:46 Warburgâs stigma: connecting with Naziâs
40:51 Is insulin responsible for cancer?
48:00 Science is not immune from politics
50:24 Prostate cancer & obesity
52:13 Pendulum swing in cancer research
54:40 Mitochondria & Cancer Connection
57:07 Naziâs fixation on cancer
Episode Show Notes: https://livelongerworld.substack.com/p/sapple
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
Thanks for listening & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.
Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
-
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev
Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Womenâs hospital, where he runs his own lab. We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium.
Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his labâs work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice.
Itâs important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation!
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld
Find me on Twitter: https://twitter.com/livelongerworld
VADIM GLADYSHEV LINKS:
Website: https://gladyshevlab.bwh.harvard.edu/2022
Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:00 Vadim Gladyshev Intro
1:28 Live Longer World
2:17 Seleniumâs dual role in aging (the good, the bad, the ugly)
11:27 Antagonistic Pleiotropy
13:53 Selenium & Cancer
15:58 Selenium Dosage (donât get too much!)
18:30 Reactive Oxygen Species, Antioxidants & Aging
22:30 Fundamental basis of Aging
24:09 Aging is damage
29:20 Single cell Epigenetic Clocks
34:22 Aging in the Womb
42:16 Parentâs lifestyle for aging in embryo
44:14 Rapamycin during development
49:06 Other compounds
51:53 Slowing Aging vs. Rejuvenation
56:08 New projects being worked on
57:17 Confidence level in extending lifespan within 30 years
59:17 Support Live Longer World
Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
Thanks for watching & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.
Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
-
Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young. In todayâs conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more.
If you want to understand how to think about your risk assessment for cardiovascular disease and how to prevent it, this conversation is for you.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/eweiss
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
ETHAN WEISS LINKS:
Website: https://profiles.ucsf.edu/ethan.weiss
Twitter: https://twitter.com/ethanjweiss
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:00 Welcome to Live Longer World
0:44 Misconceptions of heart disease / young people with heart disease
4:01 Predictors of heart disease
6:59 LDL vs HDL; Triglycerides
12:51 Small-dense LDL vs. Large fluffy LDL
16:09 Dietary Carbohydrates & heart disease risk
25:50 Inflammation & Cardiovascular risk
26:43 Lipoproteins, ApoB, Lp(a)
31:31 Statins, PCSK9 inhibitors
32:45 ApoB as gold standard risk marker
36:50 Triglycerides & Insulin resistance
40:00 Saturated Fat
42:42 Variation in Cholesterol measurement
46:03 Body composition as marker for heart disease risk
51:23 Ketogenic diets & heart health
56:43 Keyto breath sensor
1:01:46 Stress & heart disease
1:04:44 Growth hormone & heart disease
1:07:46 On the shortness of life
1:10:52 Support & Connect with
Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/eweiss
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
Thanks for listening & if you enjoy the episode, let's spread the message on longevity.
Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
-
Dr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology.
His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. His work on bioelectric signals has important applications for how we understand cancer, regenerative medicine and even aging. In fact, he is collaborating with David Sinclair to see how his work can be applied to reverse aging.
Michael Levinâs work is fascinating and will surely leave you thinking. I hope you enjoy the conversation!
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/mlevin
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
MICHAEL LEVIN LINKS:
Website: https://ase.tufts.edu/biology/labs/levin/
Twitter: https://twitter.com/drmichaellevin
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/
Live Longer World Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:40 How do cells decide what to build?
10:05 DNA is insufficient for dictating collective intelligence of cells
19:00 Anatomical Complier (End game)
22:24 History of Cellular Collective Intelligence & Ala Turing
26:30 Regenerative Medicine & Morphoceuticals
38:05 Cells forming new anatomies
44:53 Cancer as a morphogenetic problem
55:16 David Sinclair, Bioelectrics to reverse aging
57:44 Synthetic Wombs & Artificial Life
59:41 Support Live Longer World!
Episode Show Notes: https://livelongerworld.substack.com/p/mlevin
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
If you enjoy my work and wish to support it, consider sharing it with a friend or two and leaving a review on Apple podcasts.
And if you are further inclined to show love and support, you can donate on Patreon: patreon.com/livelongerworld
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
-
Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations Iâve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements.
In todayâs episode, you will learn:
- The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin
- 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril
- Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin
- Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more
- Richardâs thoughts on lifespan vs. healthspan
All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
RICHARD MILLER LINKS:
Website: http://www.richmillerlab.com/
Photography: https://richardmiller.zenfolio.com/
Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:55 Richard Miller Intro
1:51 Richard Miller Wildlife photography
3:30 ITP - the gold standard for testing longevity drugs & winning drugs
10:51 Rapamycin, Rapamycin + Acarbose
18:48 Rapamycin + Acarbose Dosing Schedule
20:15 Combination of drugs, Rapamycin + Metformin
21:56 17-Alpha Estradiol
25:45 Canagaflozin
31:34 Does Richard take the 4 winning drugs?
32:46 3 Drugs that have small lifespan effects & promising
36:30 GPLD-1 & shared mechanisms in longevity drugs
44:04 Resveratrol in ITP
46:27 NR, NMN
52:34 Curcumin, Green Tea Extract, MCT Oil
54:54 Fisetin & Senolytics
56:12 Why most published research findings are false
1:00:03 Healthspan biomarkers at the ITP
1:02:38 Can you have healthspan without lifespan?
1:07:37 Fish Oil, Spermidine, Sulforophane
1:12:13 Unpublished data Richard is excited about
1:17:47 Flying Pigs & Aubrey De Grey
1:20:00 Exponential rise in aging research
Episode Show Notes: https://livelongerworld.substack.com/p/rmiller
Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast.
Aging is universal. Let's unite in this fight.
- Laat meer zien
