Afleveringen
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William Hind, agency principal at Alpharmaxim, highlights that traditional methods of educating patients and physicians may not effectively drive behavior change. Applying behavioral science in healthcare communications is a way to understand the barriers to adopting new medicines and therapies and patient and provider reluctance to change. Behavioral science will become increasingly helpful for the pharmaceutical and medical tech industries to ensure that novel therapies, wearable devices, and at-home diagnostic equipment are successfully marketed to the right patients at the right time with accurate information.
William explains, "At present, there's a great deal of needed emphasis on educating people about diseases and any therapies that come forward. However, it may not be a lack of information inhibiting prescribing clinicians or patients from adopting a new medicine. It may be that it's an old habit of physicians, or it may be that the patients have accepted a regimen that they are reluctant to move away from. So it's about the need to try and discover all of the different aspects of what might be acting as a barrier in making sure that new medicines are adopted as quickly as possible."
"When it comes to behavioral change, I don’t think people realize quite what a science it is. You know, it's firmly rooted in psychology and sociology. There is clear evidence supporting its use. We use the COM-B model, a well-reputed approach to defining barriers. This is interesting because pharmaceuticals, in particular, and patient communications are all heavily dependent on the data and evidence, yet the way they communicate is usually governed by habit. We're trying to encourage people to look at what's needed to shift behaviors instead of just relying on habitual communication."
"There is a wealth of examples where behavior science is being used very successfully in consumer advertising and in the kinds of scenarios you mentioned. There's a lot of work in that area, but even there, real behavioral science is still on the fringes. It's not routinely adopted. So what we need to do is make sure that it is better understood. In pharmaceuticals, it isn't as adopted anywhere near as much as it should be or could be, especially given what's at stake."
#Alpharmaxim #BehavioralScience #PharmaMarketing #Medtech
alpharmaxim.com
Listen to the podcast here
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William Hind, agency principal at Alpharmaxim, highlights that traditional methods of educating patients and physicians may not effectively drive behavior change. Applying behavioral science in healthcare communications is a way to understand the barriers to adopting new medicines and therapies and patient and provider reluctance to change. Behavioral science will become increasingly helpful for the pharmaceutical and medical tech industries to ensure that novel therapies, wearable devices, and at-home diagnostic equipment are successfully marketed to the right patients at the right time with accurate information.
William explains, "At present, there's a great deal of needed emphasis on educating people about diseases and any therapies that come forward. However, it may not be a lack of information inhibiting prescribing clinicians or patients from adopting a new medicine. It may be that it's an old habit of physicians, or it may be that the patients have accepted a regimen that they are reluctant to move away from. So it's about the need to try and discover all of the different aspects of what might be acting as a barrier in making sure that new medicines are adopted as quickly as possible."
"When it comes to behavioral change, I don’t think people realize quite what a science it is. You know, it's firmly rooted in psychology and sociology. There is clear evidence supporting its use. We use the COM-B model, a well-reputed approach to defining barriers. This is interesting because pharmaceuticals, in particular, and patient communications are all heavily dependent on the data and evidence, yet the way they communicate is usually governed by habit. We're trying to encourage people to look at what's needed to shift behaviors instead of just relying on habitual communication."
"There is a wealth of examples where behavior science is being used very successfully in consumer advertising and in the kinds of scenarios you mentioned. There's a lot of work in that area, but even there, real behavioral science is still on the fringes. It's not routinely adopted. So what we need to do is make sure that it is better understood. In pharmaceuticals, it isn't as adopted anywhere near as much as it should be or could be, especially given what's at stake."
#Alpharmaxim #BehavioralScience #PharmaMarketing #Medtech
alpharmaxim.com
Download the transcript here
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Zijn er afleveringen die ontbreken?
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Dr. Avantika Waring, the Chief Medical Officer at 9amHealth, provides end-to-end individualized cardiometabolic care to people with diabetes, pre-diabetes, high blood pressure, high cholesterol, and obesity. Their focus on metabolic health includes diagnostics, medications, nutrition services, coaching, and lifestyle support in a fun, engaging and non-judgemental manner. This comprehensive virtual healthcare model extends the opportunity for patients to get the support they need to manage these chronic conditions better.
Avantika explains, "The mission behind our companies is to make high-quality, effective, and, importantly, kind care available to as many people as possible. We know that there are amazing clinicians out there, and there are patients who are super fortunate to be connected with them. But that's not everyone. There are a lot of barriers to getting access to that care, and we want to make sure that people can get access to the care that they need and that the experience is, might I say, as fun as possible for both the clinician and the patient."
"We want things to be simple for patients, and we know that most people who have a cardiometabolic condition are likely to have more than one. Sometimes, two or three. So, our goal is to make the experience as simple and streamlined as possible for the members. So if they're coming to us with a glucose issue and need labs and medication for that, but they also need coaching on their diet for heart health and cholesterol, we want to offer them all that in one experience."
#9amHealth #Diversity #Healthcare #HealthEquity #AsynchronousCare #CardiometabolicCare #MetabolicHealth #MedicationCosts2024 #DigitalHealth #EmployeeBenefits
join9am.com
Listen to the podcast here
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Dr. Avantika Waring, the Chief Medical Officer at 9amHealth, provides end-to-end individualized cardiometabolic care to people with diabetes, pre-diabetes, high blood pressure, high cholesterol, and obesity. Their focus on metabolic health includes diagnostics, medications, nutrition services, coaching, and lifestyle support in a fun, engaging and non-judgemental manner. This comprehensive virtual healthcare model extends the opportunity for patients to get the support they need to manage these chronic conditions better.
Avantika explains, "The mission behind our companies is to make high-quality, effective, and, importantly, kind care available to as many people as possible. We know that there are amazing clinicians out there, and there are patients who are super fortunate to be connected with them. But that's not everyone. There are a lot of barriers to getting access to that care, and we want to make sure that people can get access to the care that they need and that the experience is, might I say, as fun as possible for both the clinician and the patient."
"We want things to be simple for patients, and we know that most people who have a cardiometabolic condition are likely to have more than one. Sometimes, two or three. So, our goal is to make the experience as simple and streamlined as possible for the members. So if they're coming to us with a glucose issue and need labs and medication for that, but they also need coaching on their diet for heart health and cholesterol, we want to offer them all that in one experience."
#9amHealth #Diversity #Healthcare #HealthEquity #AsynchronousCare #CardiometabolicCare #MetabolicHealth #MedicationCosts2024 #EmployeeBenefits #DigitalHealth
join9am.com
Download the transcript here
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Dr. John Simon, CEO and Founder of SimonMed Imaging makes various medical imaging technologies available, including X-rays, ultrasound, MRI, and PET/CT scans, which have traditionally been used for diagnosis and tracking changes. With the SimonONE whole-body MRI scan, SimonMed offers an affordable preventative screening approach that, with the assistance of AI and advancements in imaging technology, looks for abnormalities and detects subtle changes. Ideally, MRI scans will become more routine in annual exams to catch treatable conditions sooner.
John elaborates, "About 20, 25 years ago, diagnostic imaging went from a very limited specialty within the hospital setting to an often-used technology. This great technology is used in the outpatient setting. So, I founded my first outpatient radiology office over 20 years ago, and it included some of the most advanced equipment you could obtain at that time, including cardiac CT and MRI scanners, which were incredibly fast for that time. What that technology enabled us to do was to do outpatient imaging studies very quickly, less expensively, and very accurately."
"A whole-body MRI involves a series of MRI sequences, more than one, looking at the body. Typically, we look at the head, neck, chest, abdomen, and pelvis. We do specialized sequences within those areas looking for aneurysms, looking for vascular changes in the body, looking at the health of the brain for not only excluding particularly cancers in the brain, for example, but also looking for early signs of Alzheimer's disease. In the neck, we look for cancers as well as other abnormalities."
"In the chest, abdomen, and pelvis, we not only look for vascular abnormalities but also for early signs of cancer and other abnormalities, including metabolic abnormalities within the liver. There is something called fatty liver disease, which is common in the US. So, the process involves a noninvasive MRI study with multiple different sequences looking at different areas within the body, and we put them all together in one visit."
#SimonMedImaging #MRI #WholeBodyScan #Diagnostics #AI #MedicalImaging #PreventativeMedicine
SimonMed.com
Listen to the podcast here
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Dr. John Simon, CEO and Founder of SimonMed Imaging makes various medical imaging technologies available, including X-rays, ultrasound, MRI, and PET/CT scans, which have traditionally been used for diagnosis and tracking changes. With the SimonONE whole-body MRI scan, SimonMed offers an affordable preventative screening approach that, with the assistance of AI and advancements in imaging technology, looks for abnormalities and detects subtle changes. Ideally, MRI scans will become more routine in annual exams to catch treatable conditions sooner.
John elaborates, "About 20, 25 years ago, diagnostic imaging went from a very limited specialty within the hospital setting to an often-used technology. This great technology is used in the outpatient setting. So, I founded my first outpatient radiology office over 20 years ago, and it included some of the most advanced equipment you could obtain at that time, including cardiac CT and MRI scanners, which were incredibly fast for that time. What that technology enabled us to do was to do outpatient imaging studies very quickly, less expensively, and very accurately."
"A whole-body MRI involves a series of MRI sequences, more than one, looking at the body. Typically, we look at the head, neck, chest, abdomen, and pelvis. We do specialized sequences within those areas looking for aneurysms, looking for vascular changes in the body, looking at the health of the brain for not only excluding particularly cancers in the brain, for example, but also looking for early signs of Alzheimer's disease. In the neck, we look for cancers as well as other abnormalities."
"In the chest, abdomen, and pelvis, we not only look for vascular abnormalities but also for early signs of cancer and other abnormalities, including metabolic abnormalities within the liver. There is something called fatty liver disease, which is common in the US. So, the process involves a noninvasive MRI study with multiple different sequences looking at different areas within the body, and we put them all together in one visit."
#SimonMedImaging #MRI #WholeBodyScan #Diagnostics #AI #MedicalImaging #PreventativeMedicine
SimonMed.com
Download the transcript here
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Alon Ben-Noon, CEO and board member of NeuroSense Therapeutics, is taking a unique approach to treating neurodegenerative diseases by targeting core pathologies and combining molecules to address various mechanisms. NeuroSense has seen positive clinical trial results for ALS using their lead compound PrimeC, which showed a reduction in disease progression. Research indicates the potential for this approach to be applied to other neurodegenerative diseases like Alzheimer's and Parkinson's.
Alon explains, "The main challenge is to find a therapeutic asset for a complex disease, which is still not understood well enough to date. ALS, also Alzheimer's, and I think that Parkinson's is among them as well. All of those neurodegenerative diseases are very complex and involve many mechanisms that go wrong. We try to tackle them with the therapeutic agents while we are not certain with each patient what exactly goes on. This is a huge challenge, so we need to be creative and find ways how we may be able to provide benefits to the majority of the patients, and I should be more distinct to say a benefit to some extent."
"In order to maximize the success with our therapy, we figured out that we need to target more than just one single mechanism and we need to tackle as much as we can or as many as we can. And looking at the more pertinent targets in our view and our understanding, we combine two molecules that target several mechanisms in a synergistic manner. We found molecules that can target these pathological pathways that were identified from the start. Also, it was important for us to see that they can work synergistically together on these targets."
#NeuroSense #ALS #Parkinsons #Alzheimers #NeurodegenerativeDiseases
NeuroSense-TX.com
Listen to the podcast here
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Alon Ben-Noon, CEO and board member of NeuroSense Therapeutics, is taking a unique approach to treating neurodegenerative diseases by targeting core pathologies and combining molecules to address various mechanisms. NeuroSense has seen positive clinical trial results for ALS using their lead compound PrimeC, which showed a reduction in disease progression. Research indicates the potential for this approach to be applied to other neurodegenerative diseases like Alzheimer's and Parkinson's.
Alon explains, "The main challenge is to find a therapeutic asset for a complex disease, which is still not understood well enough to date. ALS, also Alzheimer's, and I think that Parkinson's is among them as well. All of those neurodegenerative diseases are very complex and involve many mechanisms that go wrong. We try to tackle them with the therapeutic agents while we are not certain with each patient what exactly goes on. This is a huge challenge, so we need to be creative and find ways how we may be able to provide benefits to the majority of the patients, and I should be more distinct to say a benefit to some extent."
"In order to maximize the success with our therapy, we figured out that we need to target more than just one single mechanism and we need to tackle as much as we can or as many as we can. And looking at the more pertinent targets in our view and our understanding, we combine two molecules that target several mechanisms in a synergistic manner. We found molecules that can target these pathological pathways that were identified from the start. Also, it was important for us to see that they can work synergistically together on these targets."
#NeuroSense #ALS #Parkinsons #Alzheimers #NeurodegenerativeDiseases
NeuroSense-TX.com
Download the transcript here
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Dr. Kathy Reeves, President and CEO of the Arnold P. Gold Foundation, works with medical schools to promote humanistic care and is responsible for the White Coat ceremony for medical students to emphasize the need for human connection in healthcare. The Foundation is also responsible for the Thank a Resident Day and the Gold Foundation Honor Society, which recognize those doctors who meet the high standards of their peers. The development of Gold Human-Centered Spaces is a scalable solution to create healthcare environments that foster humanistic interactions. The goal is to make humanism a healthcare priority and to implement practical solutions.
Kathy explains, "With that, Arnold and Sandra knew there had to be a foundation dedicated to making sure the human connection remained central in healthcare. And that's what the Gold Foundation has done and continues to do. We are the group that is responsible for the White Coat ceremony when people enter medical school to make sure medical students are aware that it's all about the person in front of them. There are a number of other programs that we do with medical schools, and we're attached to over 90% of the medical schools across the country. We work directly with these schools to help keep healthcare human."
"There is an abundance of research out there that will show you when a patient feels well cared for, they're healthier. When the interaction goes well, the healthcare professional is healthier. Those two things alone lead to lower healthcare costs, less no-show rates, less health professional turnover. So it is in some ways the epitome of value-based care, if we really value people, it's going to save money. It's going to make the society healthier."
#GoldFoundation #Humanism #Healthcare #PatientCentered #EmpowerTeams #ThankAResidentDay
gold-foundation.org
Listen to the podcast here
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Dr. Kathy Reeves, President and CEO of the Arnold P. Gold Foundation, works with medical schools to promote humanistic care and is responsible for the White Coat ceremony for medical students to emphasize the need for human connection in healthcare. The Foundation is also responsible for the Thank a Resident Day and the Gold Foundation Honor Society, which recognize those doctors who meet the high standards of their peers. The development of Gold Human-Centered Spaces is a scalable solution to create healthcare environments that foster humanistic interactions. The goal is to make humanism a healthcare priority and to implement practical solutions.
Kathy explains, "With that, Arnold and Sandra knew there had to be a foundation dedicated to making sure the human connection remained central in healthcare. And that's what the Gold Foundation has done and continues to do. We are the group that is responsible for the White Coat ceremony when people enter medical school to make sure medical students are aware that it's all about the person in front of them. There are a number of other programs that we do with medical schools, and we're attached to over 90% of the medical schools across the country. We work directly with these schools to help keep healthcare human."
"There is an abundance of research out there that will show you when a patient feels well cared for, they're healthier. When the interaction goes well, the healthcare professional is healthier. Those two things alone lead to lower healthcare costs, less no-show rates, less health professional turnover. So it is in some ways the epitome of value-based care, if we really value people, it's going to save money. It's going to make the society healthier."
#GoldFoundation #Humanism #Healthcare #PatientCentered #EmpowerTeams #ThankAResidentDay
gold-foundation.org
Download the transcript here
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Dr. Kazu Okuda, Founder, and CEO of Universal Brain, uses neurotyping based on EEG data to better understand the different types of depression and deliver more precise treatments. To facilitate the availability of EEG data, Universal Brain has developed a next-generation EEG headset that is affordable and comfortable. The headset allows for the collection of data that can be used to analyze neural profiles of patients and tailor treatments. This precision psychiatry approach is the future of depression treatment and for identifying early warning signs of depression in the younger population.
Kazu explains, "We are using the term neurotyping to solve that kind of problem. Neurotyping is a term we use at Universal Brain, and it's a groundbreaking process of grouping individuals based on brain function measures derived from the EEG data. We'll look at specific reactions of the brain to visual and audio stimuli, which are called event-related potentials, and we are leveraging that kind of brain biomarkers and neurotype the patient based on brain function."
"By examining the functioning of the cornea or systems from attention to memory and negative bias and reward function, we aim to reduce the heterogeneity of treatment groups using the brain function biomarkers because depression has a lot of phenotypes. There is no single depression, but we call it depressions because there are tons of variations of combination of the symptoms to meet the criteria of depression. So by neurotyping patients based on brain function, we reduce the heterogeneity of depressions and lead to better outcomes."
#UniversalBrain #Neurotyping #BrainBiomarkers #Depression #PrecisionPsychiatry
universal-brain.com
Listen to the podcast here
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Dr. Kazu Okuda, Founder, and CEO of Universal Brain, uses neurotyping based on EEG data to better understand the different types of depression and deliver more precise treatments. To facilitate the availability of EEG data, Universal Brain has developed a next-generation EEG headset that is affordable and comfortable. The headset allows for the collection of data that can be used to analyze neural profiles of patients and tailor treatments. This precision psychiatry approach is the future of depression treatment and for identifying early warning signs of depression in the younger population.
Kazu explains, "We are using the term neurotyping to solve that kind of problem. Neurotyping is a term we use at Universal Brain, and it's a groundbreaking process of grouping individuals based on brain function measures derived from the EEG data. We'll look at specific reactions of the brain to visual and audio stimuli, which are called event-related potentials, and we are leveraging that kind of brain biomarkers and neurotype the patient based on brain function."
"By examining the functioning of the cornea or systems from attention to memory and negative bias and reward function, we aim to reduce the heterogeneity of treatment groups using the brain function biomarkers because depression has a lot of phenotypes. There is no single depression, but we call it depressions because there are tons of variations of combination of the symptoms to meet the criteria of depression. So by neurotyping patients based on brain function, we reduce the heterogeneity of depressions and lead to better outcomes."
#UniversalBrain #Neurotyping #BrainBiomarkers #Depression #PrecisionPsychiatry
universal-brain.com
Download the transcript here
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Greg Sturmer, CEO and Co-Founder, and Tom Jenkins, Chief Science Officer and Co-Founder of Elysium Therapeutics, talk about their SMART Opioid O2P, which aims to address the risks of taking opioids while still delivering the analgesic efficacy of opioids. The compound is designed to be resistant to abuse through snorting or injections and includes a trypsin inhibitor that prevents the release of the opioid when multiple pills are ingested. Elysium is also developing SOOPR, an opioid overdose rescue medication that has a longer duration of action to counteract the longer-lasting effects of synthetic opioids such as Fentanyl.
Greg explains, "When we talk about our SMART opioids for pain, SMART stands for Safer Medicines that Alleviate Risks and Trauma. Our space is led by our O2P hydrocodone product candidate, and O2P stands for oral overdose protection."
"So what O2P hydrocodone is designed to do is mitigate those major risks associated with existing prescription opioids, but doing so without sacrificing their superior analgesic efficacy, especially when compared to currently marketed non-opioid alternatives and those in development. We're excited to say that we've demonstrated human proof of concept in a recent study that we announced. But what I'd like to do is have Tom step in. Again, he is the inventor of our technology. He's a PhD synthetic organic chemist out of Stanford. Tom, do you want to talk about the technology and maybe compare it to past attempts at abuse-deterrent formulation?"
Tom elaborates, "How we answer the question and how our technology works is fairly straightforward. What we've done is we've taken the opioid molecule with hydrocodone, and we can use any opioid molecule, morphine, oxycodone, or any of the prescription opioids. What we do is make a molecular modification to the drug. The key part of that is the conditional bioavailability of the drug is the fact that the drug has to see digestive enzyme, specifically trypsin, in the small intestine before it can be converted to an active drug."
#ElysiumTherapeutics #Opioids #OpioidAbuse #SyntheticOpioids #OpioidUseDisorder #PainManagement #SaferMedicines
ElysiumRX.com
Listen to the podcast here
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Greg Sturmer, CEO and Co-Founder, and Tom Jenkins, Chief Science Officer and Co-Founder of Elysium Therapeutics, talk about their SMART Opioid O2P, which aims to address the risks of taking opioids while still delivering the analgesic efficacy of opioids. The compound is designed to be resistant to abuse through snorting or injections and includes a trypsin inhibitor that prevents the release of the opioid when multiple pills are ingested. Elysium is also developing SOOPR, an opioid overdose rescue medication that has a longer duration of action to counteract the longer-lasting effects of synthetic opioids such as Fentanyl.
Greg explains, "When we talk about our SMART opioids for pain, SMART stands for Safer Medicines that Alleviate Risks and Trauma. Our space is led by our O2P hydrocodone product candidate, and O2P stands for oral overdose protection."
"So what O2P hydrocodone is designed to do is mitigate those major risks associated with existing prescription opioids, but doing so without sacrificing their superior analgesic efficacy, especially when compared to currently marketed non-opioid alternatives and those in development. We're excited to say that we've demonstrated human proof of concept in a recent study that we announced. But what I'd like to do is have Tom step in. Again, he is the inventor of our technology. He's a PhD synthetic organic chemist out of Stanford. Tom, do you want to talk about the technology and maybe compare it to past attempts at abuse-deterrent formulation?"
Tom elaborates, "How we answer the question and how our technology works is fairly straightforward. What we've done is we've taken the opioid molecule with hydrocodone, and we can use any opioid molecule, morphine, oxycodone, or any of the prescription opioids. What we do is make a molecular modification to the drug. The key part of that is the conditional bioavailability of the drug is the fact that the drug has to see digestive enzyme, specifically trypsin, in the small intestine before it can be converted to an active drug."
#ElysiumTherapeutics #Opioids #OpioidAbuse #SyntheticOpioids #OpioidUseDisorder #PainManagement #SaferMedicines
ElysiumRX.com
Download the transcript here
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Dr. Nate Favini, the first Chief Medical Officer of Pair Team, aims to connect underserved communities to high-quality, ongoing healthcare by providing medical, behavioral, and social services. Working with people who rely on Medicaid, who are experiencing homelessness and substance use disorders, and who have had recent interactions with the criminal justice system requires innovation and collaboration of government agencies, community-based organizations, and healthcare providers. With a focus on outcomes and cost, this value-based approach is reaching patients where they are, often using mobile technology and offering virtual care for tracking and improving health outcomes.
Nate explains, "In general, and specifically for the folks that we care for, value-based care means attention to the outcomes that we're delivering. For me, as a physician, that starts with the health outcomes that we deliver. So, are we improving people's health? Are we doing it on the measurable outcomes in terms of the conditions that they have, whether it's their blood sugar control for diabetes or their blood pressure if they have hypertension?"
"On the social outcomes that are drivers of people's health issues. So, are we getting you housed? Are we getting you a reliable and stable source of nutritious food? Because these are the things that make a difference in the health outcomes we're looking for."
"And then, of course, value-based care also implies attention to the cost of care. Are we delivering those outcomes at a cost that makes sense? And we've shown that we're very good at being able to achieve both of those things at the same time. At Pair Team, we have great outcomes in terms of hemoglobin A1C and blood pressure and improvements in depression. At the same time, we're offering people services that allow them to go to the emergency department and be in the hospital last. And so the real sweet spot in value-based care is if you can improve the outcomes for the folks who need it and return those investments to the system in the shape of lower spending."
#PairTeam #SDOH #HealthcareAccess #EnhancedCareManagement #DigitalHealth
pairteam.com
Listen to the podcast here
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Dr. Nate Favini, the first Chief Medical Officer of Pair Team, aims to connect underserved communities to high-quality, ongoing healthcare by providing medical, behavioral, and social services. Working with people who rely on Medicaid, who are experiencing homelessness and substance use disorders, and who have had recent interactions with the criminal justice system requires innovation and collaboration of government agencies, community-based organizations, and healthcare providers. With a focus on outcomes and cost, this value-based approach is reaching patients where they are, often using mobile technology and offering virtual care for tracking and improving health outcomes.
Nate explains, "In general, and specifically for the folks that we care for, value-based care means attention to the outcomes that we're delivering. For me, as a physician, that starts with the health outcomes that we deliver. So, are we improving people's health? Are we doing it on the measurable outcomes in terms of the conditions that they have, whether it's their blood sugar control for diabetes or their blood pressure if they have hypertension?"
"On the social outcomes that are drivers of people's health issues. So, are we getting you housed? Are we getting you a reliable and stable source of nutritious food? Because these are the things that make a difference in the health outcomes we're looking for."
"And then, of course, value-based care also implies attention to the cost of care. Are we delivering those outcomes at a cost that makes sense? And we've shown that we're very good at being able to achieve both of those things at the same time. At Pair Team, we have great outcomes in terms of hemoglobin A1C and blood pressure and improvements in depression. At the same time, we're offering people services that allow them to go to the emergency department and be in the hospital last. And so the real sweet spot in value-based care is if you can improve the outcomes for the folks who need it and return those investments to the system in the shape of lower spending."
#PairTeam #SDOH #HealthcareAccess #EnhancedCareManagement #DigitalHealth
pairteam.com
Download the transcript here
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Daniel Barvin, VP of Operations and Patient Advocacy at Coya Therapeutics discusses the challenges of treating ALS (Amyotrophic Lateral Sclerosis) and the company's approach to developing therapies for this heterogeneous disease. Focusing on a combination modality, Coya is developing therapies effective for sporadic and genetic ALS, targeting regulatory T cells and reducing inflammation to slow disease progression. Daniel, who carries a genetic variant for ALS and FTD (Frontotemporal Dementia), emphasizes the need for resources and support for the next generation of pre-symptomatic genetic ALS patients.
Daniel explains, "Coya is based upon the discovery of Dr. Stanley Appel of Houston Methodist, that all neurodegenerative diseases, we believe, also autoimmune and a few metabolic diseases, drive an inflammatory response. The death of a motor neuron or damage to a motor neuron is an alert to the body that it should send inflammation to fix that motor neuron or beta-amyloid plaque buildup. Unfortunately, inflammation cannot fix these issues and, therefore, decides to take out a damaged part of the body. The death of the motor neuron then spurs more inflammation, and the inflammation that rises in the body eventually damages what are called regulatory T cells, the most immunomodulating cells in the body. Once regulatory T cells are damaged, inflammation becomes a persistent condition and drives further degeneration and eventually death."
"Coya is founded upon the idea that we can affect the number and efficacy of regulatory T cells. This was our first pathway to affecting change in ALS. We have now gone to a combination therapy, which will be a biologic made up of two FDA-approved drugs in our own formulation. We believe this combination can increase the efficacy and number of regulatory T cells and reduce inflammation. We believe this combination effect in such a heterogeneous disease will have more efficacy than just a single modality."
$COYA #CoyaTherapeutics #ALS #GeneticALS #PresymptomaticALS #PatientAdvocacy #RareDiseases
coyatherapeutics.com
Listen to the podcast here
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Daniel Barvin, VP of Operations and Patient Advocacy at Coya Therapeutics discusses the challenges of treating ALS (Amyotrophic Lateral Sclerosis) and the company's approach to developing therapies for this heterogeneous disease. Focusing on a combination modality, Coya is developing therapies effective for sporadic and genetic ALS, targeting regulatory T cells and reducing inflammation to slow disease progression. Daniel, who carries a genetic variant for ALS and FTD (Frontotemporal Dementia), emphasizes the need for resources and support for the next generation of pre-symptomatic genetic ALS patients.
Daniel explains, "Coya is based upon the discovery of Dr. Stanley Appel of Houston Methodist, that all neurodegenerative diseases, we believe, also autoimmune and a few metabolic diseases, drive an inflammatory response. The death of a motor neuron or damage to a motor neuron is an alert to the body that it should send inflammation to fix that motor neuron or beta-amyloid plaque buildup. Unfortunately, inflammation cannot fix these issues and, therefore, decides to take out a damaged part of the body. The death of the motor neuron then spurs more inflammation, and the inflammation that rises in the body eventually damages what are called regulatory T cells, the most immunomodulating cells in the body. Once regulatory T cells are damaged, inflammation becomes a persistent condition and drives further degeneration and eventually death."
"Coya is founded upon the idea that we can affect the number and efficacy of regulatory T cells. This was our first pathway to affecting change in ALS. We have now gone to a combination therapy, which will be a biologic made up of two FDA-approved drugs in our own formulation. We believe this combination can increase the efficacy and number of regulatory T cells and reduce inflammation. We believe this combination effect in such a heterogeneous disease will have more efficacy than just a single modality."
$COYA #CoyaTherapeutics #ALS #GeneticALS #PresymptomaticALS #PatientAdvocacy #RareDiseases
coyatherapeutics.com
Download the transcript here
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Dr. Bala Hota, Senior VP and Chief Informatics Officer at Tendo, emphasizes the importance of leveraging data to improve patient care and operational performance in healthcare and overcome biases in access. Focusing on quality measures and integration of structured and unstructured data, Tendo has developed services that support providers, patients, and caregivers using multiple avenues of communication. The acquisition of MDsave allows for a marketplace that provides transparent pricing for medical services, adding to this omnichannel healthcare model.
Bala explains, "At Tendo, our vision is to be the trusted connection between patients, providers, and caregivers, using an intuitive and seamless interface to provide that optimum experience. The way we approach things is we have a number of different ways that people interact with our application and our software. We have a patient care journey application, which helps patients navigate through complex care pathways."
"We have an insights offering that uses a variety of engines to look at electronic record data and claims data to identify cohorts where there could be opportunities to provide better care, provide better documentation, and take action. Then, we have an outreach product where we can take those insights and drive them through to actions through to the patient, including self-scheduling. So this is all on a common software platform, which allows us to deploy faster and have configurability, but we're focusing on those three main areas."
"The way we come at it is from the quality perspective. If you're doing the right thing and trying to optimize the accuracy of capturing that information, the revenue will follow. One of our use cases is around hospital rankings and how you improve risk adjustment to make sure that you're getting credit for the quality you're providing and that your documentation is fully accurate. We find revenue increases as a result of that effort."
#Tendo #Healthcare #SoftwareSolutions #PatientExperiences
tendo.com
Listen to the podcast here
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Dr. Bala Hota, Senior VP and Chief Informatics Officer at Tendo, emphasizes the importance of leveraging data to improve patient care and operational performance in healthcare and overcome biases in access. Focusing on quality measures and integration of structured and unstructured data, Tendo has developed services that support providers, patients, and caregivers using multiple avenues of communication. The acquisition of MDsave allows for a marketplace that provides transparent pricing for medical services, adding to this omnichannel healthcare model.
Bala explains, "At Tendo, our vision is to be the trusted connection between patients, providers, and caregivers, using an intuitive and seamless interface to provide that optimum experience. The way we approach things is we have a number of different ways that people interact with our application and our software. We have a patient care journey application, which helps patients navigate through complex care pathways."
"We have an insights offering that uses a variety of engines to look at electronic record data and claims data to identify cohorts where there could be opportunities to provide better care, provide better documentation, and take action. Then, we have an outreach product where we can take those insights and drive them through to actions through to the patient, including self-scheduling. So this is all on a common software platform, which allows us to deploy faster and have configurability, but we're focusing on those three main areas."
"The way we come at it is from the quality perspective. If you're doing the right thing and trying to optimize the accuracy of capturing that information, the revenue will follow. One of our use cases is around hospital rankings and how you improve risk adjustment to make sure that you're getting credit for the quality you're providing and that your documentation is fully accurate. We find revenue increases as a result of that effort."
#Tendo #Healthcare #SoftwareSolutions #PatientExperiences
tendo.com
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