Afleveringen
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Signs of focal epilepsy before the seizures start: hear all about it from neurologist and epileptologist Dr. Jacob Pellinen, who shares with us his research and results proving that people can experience things like depression or learning difficulties at school or work before seizure onset.
Chapters ๐
00:00 Trailer & intro
00:44 Meet Jacob
02:34 Epilepsy is more than seizures
02:54 Later epilepsy diagnosis & The Human Epilepsy Project
03:05 โLater onset focal epilepsy with roots in childhood: Evidence from early learning difficulty and brain volumes in the Human Epilepsy Projectโ paper
07:29 Anticipating seizure onset
08:30 Improving recognition of seizure symptoms
09:02 Seizing for years before diagnosis
10:33 Learning difficulties not Intellectual Disability
13:18 Closing thoughts & thanks๐ Episode page and transcript epilepsysparks.com/epilepsy-sparks-insights/unrecognised-focal-onset-childhood
๐ More about Jacob epilepsysparks.com/guests/jacob-pellinen
๐ More Epilepsy Sparks Insights epilepsysparks.com/epilepsy-sparks-insights
๐ฅ Watch on YouTube youtube.com/@EpilepsySparksInsights
๐ค Donโt understand terms used? Check out the Epilepsy Sparks Glossary epilepsysparks.com/glossary
๐ฒ Join us on social media!
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ใฐ๏ธ Bluesky epilepsysparks -
Memory problems are one of the most common and frustrating symptoms experienced by people with an epilepsy - but what actually causes them? And how can we "treat" them? Dr. Laurie Miller explains how different types of memory work, why memory difficulties are often linked to the underlying brain pathology rather than just seizures, and what evidence-based strategies and techniquest may help improve everyday functioning.
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๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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Zijn er afleveringen die ontbreken?
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What does epilepsy care look like when a clinician has to see so many people each day?! Prof. Mamta Singh shares what high-volume epilepsy care really looks like in New Delhi - from specialist epilepsy clinics to outreach services across rural regions. We discuss why seizure freedom doesn't automatically equate to good quality of life, how experienced clinicians detect mental health and functional symptoms through observation and communication, cultural aspects, and why listening carefully to patients can sometimes be just as important as EEGs, MRIs, and other investigations!
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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Can exercise improve memory in people with an epilepsy? Dr. Jane Allendorfer explores how physical activity may drive measurable changes in verbal learning, memory function, and hippocampal connectivity! Building on a 6-week pilot study showing improved memory performance, we hear about her newly completed randomised clinical trial investigating exercise for memory rehabilitation in epilepsy, aiming to determine whether changes in brain networks can explain cognitive improvement and help predict who will benefit from intervention.
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ More Epilepsy Sparks Insights ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights
๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
๐ฒ Join us on social media!
- LinkedIn https://www.linkedin.com/company/epilepsy-sparks
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Canโt find where seizures start in drug-resistant epilepsy? Christos Papadelis, Ph.D, biomedical engineer and researcher, explains how ultra-high-resolution brain mapping and AI are improving seizure localisation and surgical decision-making in children. This episode explores how combining advanced neurophysiology with AI can identify seizure origins and networks, predict surgical outcomes, and move care beyond traditional limitations.
This episode is sponsored by EASEEยฎ by Precisis GmbH and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ More Epilepsy Sparks Insights ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights
๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
๐ฒ Join us on social media!
- LinkedIn https://www.linkedin.com/company/epilepsy-sparks
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Is seizure freedom enough in epilepsy care? Dr. Lucretia Long, epilepsy specialist nurse practitioner, shares why care must go beyond seizure control - with psychiatric symptoms, medication side effects, and cognitive challenges shaping quality of life just as much as seizures. This episode explores how to individualise care, why patient priorities must lead decisions, and how small, realistic changes can improve wellbeing.
This episode is sponsored by EASEEยฎ by Precisis GmbH and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ More Epilepsy Sparks Insights ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights
๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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Delays in epilepsy surgery referral are not just about access and are not limited to one region. Epileptologist Asst. Prof. Juan Perez discusses paediatric epilepsy surgery across Latin America, where services exist but remain underutilised, and how misconceptions, training gaps, and system-level barriers continue to prevent eligible children from being referred for surgical evaluation, as well as what needs to change to improve access and outcomes.
This episode is sponsored by EASEEยฎ by Precisis GmbH and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ More Epilepsy Sparks Insights ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights
๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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๐ฒ Join us on social media!
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What happens when epilepsy medication doesnโt work? Prof. John Duncan explains how treatment decisions evolve beyond medication, from resective surgery to neuromodulation, and how patients and clinicians weigh these options together. The conversation covers real-world outcomes, risks, and the balance between seizure control, cognitive function, and quality of life.
This episode is sponsored by EASEEยฎ by Precisis GmbH and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ More Epilepsy Sparks Insights ๐๐ป
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๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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Why does epilepsy still receive so little funding, attention and public understanding compared to other diseases? Intellectual disability nurse Jay Price discusses why epilepsy remains underfunded and badly marketed, alongside misdiagnosis, quality of life, and how co-produced training could improve epilepsy care!
This episode is sponsored by EASEEยฎ by Precisis GmbH and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights/epilepsy-ignored
๐ More about Jay ๐๐ป
https://www.epilepsysparks.com/guests/jay-price
๐ Paper "Epilepsy, it's just not sexy, is it?โ: A qualitative exploration into health and social care professionals' perspectives of people with intellectual disabilities and epilepsy, in social care" ๐๐ป
https://www.epilepsybehavior.com/article/S1525-5050(25)00437-8/fulltext
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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Many epilepsy lesions that cause seizures are missed on routine MRI scans, delay diagnosis and surgery. Dr. Konrad Wagstyl discusses his research using AI and large MRI datasets to detect subtle abnormalities such as focal cortical dysplasia and hippocampal sclerosis. The conversation explores how these tools help identify surgical candidates earlier and improve outcomes in epilepsy!
This episode is sponsored by EASEEยฎ by Precisis GmbH and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights/mri-lesion-detection-ai
๐ More about Konrad ๐๐ป
https://www.epilepsysparks.com/guests/konrad-wagstyl
๐ Paper "Automated and Interpretable Detection of Hippocampal Sclerosis in Temporal Lobe Epilepsy: AID-HS" ๐๐ป
https://onlinelibrary.wiley.com/doi/full/10.1002/ana.27089
๐๏ธ MELD project guide ๐๐ป
https://www.youtube.com/@MELDproject
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider! ๐ค
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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Generalised epilepsy is often described as involving the whole brain at once. But does it start all at once? Dr. Frederic Schaper discusses research mapping subtle brain abnormalities to shared brain networks in generalised epilepsy, and how these networks overlap with targets used for deep brain stimulation. The conversation explores what this may reveal about seizure mechanisms and future neuromodulation research.
This episode is sponsored by EASEEยฎ by Precisis GmbH and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights/generalised-epilepsy-network-dbs
๐ More about Frederic ๐๐ป
https://www.epilepsysparks.com/guests/frederic-schaper
๐ Paper "A generalized epilepsy network derived from brain abnormalities and deep brain stimulation" ๐๐ป
https://www.nature.com/articles/s41467-025-57392-7
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider! ๐ค
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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Psychiatric symptoms are common in the epilepsies, yet they are often overlooked in clinical care. Dr. Andres M. Kanner, epileptologist and Professor of Clinical Neurology at the University of Miami, explains why mental health symptoms are central to epilepsy outcomes - not peripheral! Topics include depression, anxiety, psychosis, ADHD, suicide risk, family psychiatric history, and how these factors influence antiseizure medication choices and quality of life.
This episode is sponsored by EASEEยฎ by Precisis GmbH and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights/mental-health-epilepsy
๐ More about Andres ๐๐ป
https://www.epilepsysparks.com/guests/andres-miguel-kanner
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ More Epilepsy Sparks Insights ๐๐ป
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๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider! ๐ค
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
๐ฒ Join us on social media!
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Flash-back to our most popular episode*! Epileptologist & neurologist Dr. รngel Aledo-Serrano talks of his review and opinion on a former paper regarding the antiseizure medication Levetiracetam/Keppra, its effectiveness in controlling seizures, but also the importance of precision medicine. He also speaks of the need to improve prescribing and avoid polypharmacy for people with an epilepsy, the need for further qualitative research into treatment and care, and convincing clinicians that epilepsy is far more than seizures alone. This episode is sponsored by EASEEยฎ by
This episode is sponsored by EASEEยฎ by Precisis GmbH, who had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights/keppra-levetiracetam-quality-of-life
๐ More about รngel ๐๐ป
https://www.epilepsysparks.com/guests/angel-aledo-serrano
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider! ๐ค
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
๐ฒ Join us on social media!
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*2023
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Who should receive genetic testing in epilepsy, and how should results really be interpreted? Epileptologist and scientist Dr. Christian Bosselmann explores genome sequencing, diagnostic yield, variants of uncertain significance, and why results are rarely black and white. The discussion highlights how quickly things are changing in epilepsy genetics and how re-analysis and improved interpretation can meaningfully influence clinical decision-making. This episode is sponsored by EASEEยฎ by Precisis GmbH, who had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights/genetic-testing-variant-interpretation
๐ More about Christian ๐๐ป
https://www.epilepsysparks.com/guests/christian-bosselmann
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
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๐ More Epilepsy Sparks Insights ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights
๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider! ๐ค
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
๐ฒ Join us on social media!
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โ
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Who is already using generative AI in health care, and what does the evidence actually show? Researcher Charlotte Blease, PhD, examines the positives, patient and clinician uptake, emerging risks, and where major gaps in training, policy, and research remain. The discussion explores mental health use, long-term conditions, empathy, and why regulation is struggling to keep pace with real-world practice.
This episode is sponsored by EASEEยฎ by Precisis and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights/ai-in-healthcare-evidence๐ More about Charlotte ๐๐ป
https://www.epilepsysparks.com/guests/charlotte-blease๐ Join the Epilepsy Sparks community with our merch ๐๐ป
https://epilepsy-sparks.creator-spring.com๐ More Epilepsy Sparks Insights ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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- Bluesky https://bsky.app/profile/epilepsysparks.bsky.social โ -
Accelerated brain ageing is a key feature of epilepsy that cannot be explained by seizures alone. Drawing on longitudinal imaging and biomarker research, Dr. Marian Galovic discusses neurodegeneration beyond seizure activity and the clinical importance of early intervention.
This episode is sponsored by EASEEยฎ by Precisis and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights/neurodegeneration-brain-ageing๐ More about Marian ๐๐ป
www.epilepsysparks.com/guests/marian-galovic๐ Join the Epilepsy Sparks community with our merch ๐๐ป
https://epilepsy-sparks.creator-spring.com๐ More Epilepsy Sparks Insights ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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- Bluesky https://bsky.app/profile/epilepsysparks.bsky.social โ -
Seizures are often the focus in childhood epilepsies, but they certainly are not the only symptoms affecting outcomes and quality of life. This episode with Prof. Kette Valente looks at the non-seizure features that matter personally and clinically, why they can be missed, and why identifying them early can change care and long-term impact.
This episode is sponsored by EASEEยฎ by Precisis and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights//seizures-not-only-problem๐ More about Kette ๐๐ป
https://www.epilepsysparks.com/guests/kette-valente๐ Join the Epilepsy Sparks community with our merch ๐๐ป
https://epilepsy-sparks.creator-spring.com๐ More Epilepsy Sparks Insights ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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Bluesky https://bsky.app/profile/epilepsysparks.bsky.social โ -
Routine EEG provides a brief snapshot of brain activity and may not capture seizures or epileptiform activity. In this conversation, neurologist Prof. Norman Delanty explains how extended and implantable EEG monitoring can improve assessment of seizure burden, support treatment decisions, and clarify diagnosis and management when short recordings are insufficient.
This episode is sponsored by EASEEยฎ by Precisis and had no influence over the editorial content or discussion. Learn more about EASEEยฎ here: https://precisis.de/en
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights/long-term-eeg-monitoring
๐ More about Norman ๐๐ป
https://www.epilepsysparks.com/guests/norman-delanty
๐ Related paper ๐๐ป
"Unilateral ultra long-term subcutaneous EEG monitoring in drug-refractory idiopathic generalized epilepsy" https://onlinelibrary.wiley.com/doi/10.1111/epi.18644
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๐ More Epilepsy Sparks Insights ๐๐ป
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๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
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In part two of this conversation, Dr. Ching Soong Khoo discusses practical approaches to managing obesity in epilepsy, including exercise safety, diet, and multidisciplinary care. The episode highlights why weight and physical health are often overlooked in routine practice, and how simple clinical changes can support better quality of life and overall outcomes in people with an epilepsy.
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights/obesity-quality-of-life
๐ More about Ching Soong ๐๐ป
https://www.epilepsysparks.com/guests/ching-soong-khoo
๐ Related publications
- โHigh prevalence of obesity and reduced physical activity among people with epilepsy: A single-centre cross-sectional studyโ https://www.sciencedirect.com/science/article/pii/S1525505025004755
- โEpilepsy, seizures, physical exercise, and sports: A report from the ILAE Task Force on Sports and Epilepsyโ https://pubmed.ncbi.nlm.nih.gov/26662920
- โStop stigma, start exercising: How clinicians can encourage people with epilepsy to engage in physical activityโ https://www.ilae.org/journals/epigraph/epigraph-vol-25-issue-1-winter-2023/stop-stigma-start-exercising-how-clinicians-can-encourage-people-with-epilepsy-to-engage-in-physical-activity
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
https://epilepsy-sparks.creator-spring.com
๐ More Epilepsy Sparks Insights ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights
๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
๐ฒ Join us on social media!
LinkedIn https://www.linkedin.com/company/epilepsy-sparks
Instagram https://www.instagram.com/epilepsysparks
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Bluesky https://bsky.app/profile/epilepsysparks.bsky.social
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Why is obesity so common in people with epilepsy - and why is it often overlooked in clinical care? Dr. Ching Soong Khoo shares new research findings on obesity prevalence, physical activity, and mobility, and discusses how fear, diet, and behaviour intersect with epilepsy management. The episode highlights why addressing weight alongside seizure control matters for long-term health and quality of life.
๐ More about episode (inc. transcription) ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights/obesity-health-fitness
๐ More about Ching Soong ๐๐ป
https://www.epilepsysparks.com/guests/ching-soong-khoo
๐ Related publications
- โHigh prevalence of obesity and reduced physical activity among people with epilepsy: A single-centre cross-sectional studyโ https://www.sciencedirect.com/science/article/pii/S1525505025004755
- โEpilepsy, seizures, physical exercise, and sports: A report from the ILAE Task Force on Sports and Epilepsyโ https://pubmed.ncbi.nlm.nih.gov/26662920
- โStop stigma, start exercising: How clinicians can encourage people with epilepsy to engage in physical activityโ https://www.ilae.org/journals/epigraph/epigraph-vol-25-issue-1-winter-2023/stop-stigma-start-exercising-how-clinicians-can-encourage-people-with-epilepsy-to-engage-in-physical-activity
๐ Join the Epilepsy Sparks community with our merch ๐๐ป
https://epilepsy-sparks.creator-spring.com
๐ More Epilepsy Sparks Insights ๐๐ป
https://www.epilepsysparks.com/epilepsy-sparks-insights
๐ง Listen to the Epilepsy Sparks Insights podcast on Apple, Spotify, or your favourite provider!
๐ค Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
๐ฒ Join us on social media!
LinkedIn https://www.linkedin.com/company/epilepsy-sparks
Bluesky https://bsky.app/profile/epilepsysparks.bsky.social
Instagram https://www.instagram.com/epilepsysparks
Facebook https://www.facebook.com/epilepsysparks
TikTok https://www.tiktok.com/@epilepsysparks
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