Afleveringen
-
Those two gigantic PSMA review papers in European Urology - Perera et al 2016 and Perera et al 2020 - have been cited more than 2000 times and have been the definitive reference for anyone writing about PSMA PET/CT in the past ten years. And they have just been updated in two new papers just published in European Urology! Previous first author (Marlon) Perera, has moved to senior author, while Elio Mazzone has led both papers as first author, co-ordinating a massive effort between research teams in Melbourne and Milano. One paper is focused on diagnosis and staging, and the other on assessment of recurrence.
GU Cast co-Hosts Declan Murphy and Renu Eapen are joined from Milano by Elio Mazzoni and Alberto Briganti, and in studio by Marlon Perera, to summarise some of the key findings, and describe the immense effort which went into these papers. Worthy successors to the Perera et al papers of the past!Even better on our YouTube channel
Links:
Paper 1: PSMA PET/CT for diagnosis and staging
Paper 2: PSMA PET/CT for recurrence -
A beachside interview with Michael Hofman to hear all the PSMA theranostic highlights at ASCO this year! Yes we left our suburban studio in Melbourne and wandered down to St Kilda beach to track down Michael for a beer and a chat. Even in mid-Winter we enjoyed sitting out in a beachside shack at the Beachcomber Cafe and Beach Bar.
Michael shot some great interviews in Chicago with top clinicians in Nuclear Medicine including Bastiaan Privé, Louise Emmet, Jeremie Calais, Urologist Alberto Briganti, and Medical Oncologist Rana McKay. Great multidisciplinary perspectives on the Bullseye trial, Violet, Enza-P plus much more. Including a chat about the great promise of CAIX in renal cancer.
With your usual hosts, Renu Eapen and Declan MurphyEnjoy the beachside chat even more on our YouTube channel
GU Cast Conference Highlights are supported by our Gold Partners, Bayer China.
Links:
Beachside Bar, St Kilda -
Zijn er afleveringen die ontbreken?
-
What is Histolog?? Well, now that intra operative margin assessment is a such a hot topic in prostate cancer surgery after the Neurosafe RCT read-out, we thought we would dive into one of the other new technologies for doing something similar, but without the pragmatic challenges of frozen section. The idea is to assess the surgical margin of the prostate at the time of surgery to improve nerve sparing and sexual function for patients.
We are joined by Professor Greg Shaw (University College London, UK), PI of the Neurosafe Proof trial, which we already featured following their Lancet Oncology paper in March 2025, and our colleague Professor Nathan Lawrentschuk (Peter MacCallum Cancer Centre, AUS), who is leading a study of the Histolog device here in Melbourne. We chat first about Neurosafe and why intra-operative margin assessment is important, and then dive into Histolog which Greg has some experience with.
Histolog uses confocal laser microscopy to assess the prostate specimen at the time of surgery, with a similar principle to frozen section analysis as used in the Neurosafe technique. However Histolog offers a lot more convenience and removes some of the practical barriers we face with frozen section, which are barriers to implementation. But is it as good as frozen section? Join your usual hosts Declan Murphy and Renu Eapen to find out more.
Many thanks to our Silver Partners, Device Technologies, who are distributing the Histolog technology here in Australia, and to Samantree who are the manufacturers of the Histolog device.This episode better enjoyed on our YouTube channel (if you don't mind some surgical scenes)!
Links
Previous GU Cast on Neurosafe with Greg Shaw and colleagues
Histolog device manufacturer website -
A wonderful meandering chat with Ketan Badani (Urologist, Mt Sinai, NYC)! We took him for a wine tour in the Yarra Valley, stopping for a pod chat at Rochford Winery about screening for prostate cancer in older men, plus a great tour around Healesviile Sanctuary to introduce Ketan to some Australian wildlife. Then back in Melbourne we had another chat, this time a bit of future-gazing about the future of surgery, and Declan and Ketan trade tales about EMR (that's Electronic Medical Record) delinquency.
Ketan was visiting Melbourne as a guest of Device Technologies to speak at the Epworth Healthcare Robotic Urology Masterclass. And what a great guest he was!
With your usual hosts Renu Eapen and Declan Murphy. Thanks to our fantastic guide Trish at Healesville Sanctuary, and Beatrice who looked after us at Rochford Winery.This one much better enjoyed on our YouTube channel!
Links:
Rochford Winery
Healesville Sanctuary -
A Masterclass in advanced kidney cancer today with the great Danny Heng (University of Calgary, Canada), and our own Lewis Au (Peter MacCallum Cancer Centre, Melbourne). Both popped into the GU Cast studio while Danny was in Australia doing some lectures and visiitng us at Peter Mac.
We challenged Danny and Lewis to simplify three hot topics in kidney cancer, ideal if (like us) you find it difficult to keep up with this fast-moving area. The three areas are:
1. What sort of patient is this? Risk stratification made easy (by Danny, Master of the universe of Risk Stratification in kidney cancer)
2. Novel scans and biomarkers in kidney cancer - a bluffers guide
3. Neoadjuvant and adjuvant therapies in kidney cancer - what the urologist needs to know
Even better on our YouTube channel -
Meet the young new faces of collaborative urological research!! GU Cast host Declan Murphy discusses the latest in international collaborative trials with A/Prof Veeru Kasivisvanathan, Dr Alexander Ng, and highly ambitious medical students, Miss Aishwarya Shah and Mr Alexander Dudko. They discuss their latest research from the COMPASS group including the PRIME trial (bpMRI vs mpMRI in detecting prostate cancer), and upcoming PARADIGM (AI vs Radiologists in detecting prostate cancer trials. And from BURST Urology we hear an update from the RESECT (can audit and feedback improve TURBT outcomes?) trial. The team discusses mentorship and bringing up the next generation of early career researchers, including medical students and early-stage trainees.
Even better on our Youtube channel
Links:
· COMPASS
· PRIME DOI
· PARADIGM DOI
· BURST
· RESECT DOI -
When Fred Saad (Urologist, University of Montreal, Montreal) and Andrew Weickhardt (Medical Oncologist, Austin Health, Melbourne) popped into our studio recently we decided to pick their brains on a few hot topics in mHSPC - we called it the ABC of mHSPC! Fred was in Melbourne to visit Peter Mac and do some educational talks and we loved welcoming him back on GU Cast.
A is for ARPIs - who/when/which?
B is for treatment Break - can we use an intermittent approach to ADT/ARPI doublets without yet having trials in the ARPI era to guide us?
C is for Chemo - surely there is almost no role for docetaxel chemo in the ARPI era?? Or so asks Declan, well known triplet therapy sceptic! Do Fred and Andrew agree??!
A great overview of hot topics in mHSCP! Thanks to Fred and Andrew! With your usual hosts Declan Murphy and Renu Eapen.Even better on our YouTube channel
-
A big welcome back to EAU Guideline gurus, Dr Derya Tilki (Martini-Klinik, Hamburg, Germany), and Dr Gianluca Giannarini (Santa Maria della Misericordia University Hospital, Udine, Italy), for an overview of the major headlines from this year's EAU Guideline update. Derya is Deputy Chair of the EAU Prostate Cancer Guideline Committee and has picked out four areas to discuss. These are:
1. New stratification for favourable and unfavourable prostate cancer
2. PSMA PET/CT now recommended for unfavourable intermediate-risk cancer
3. No change to PLND recommendations due to lack of benefit in MSKCC RCT update
4. Importance of multidisciplinary approach for mHSPC
So tune in so you can pretend you have read the full 250 page 2025 Guideline!!
Your usual co-hosts are Professor Declan Murphy and Dr Renu Eapen.
Even better on our Youtube channel
Links:
Updated 2025 EAU Prostate Cancer Guideline -
For serious PSMA theranostics enthusiasts!!! We bring you the ninth of our collaborative PSMA webinars over the past five years, in collaboration with our team at ProsTIC and at the Prostate Cancer Foundation in the US. A truly outstanding faculty presenting today including Misha Beltran, Marty Pomper, Ed Kwan and Louise Emmett.
Co-hosted by Declan Murphy and Michael Hofman with a welcome from Howard Soule and Andrea Miyahira. Declan and Michael are joined in studio by Louise Kostos who helps field the many questions from the huge global audience who joined us live.Much better appreciated on our YouTube channel where you can see all the presentations
-
What is the da Vinci Single Port (SP) robot and is it any good? Is it easy to transition from the multiport robot to a single port robot? What about Retzius-sparing prostatectomy using the SP robot? GU Cast hosts Declan Murphy and Renu Eapen learn the answers to these questions and more when we visit top prostate cancer surgeons Dr Declan Cahill and Prof Chris Eden at London Bridge Hospital, to see the UK's only SP robot in action. The SP robot has been approved in the US for a few years, and now approved in Europe and Australia, so we hope to have it available for our patients very soon. Plus we see how they use the Neurosafe intra-operative margin assessment technique at London Bridge Hospital.
This one definitely best enjoyed on our YouTube channel
This is a Themed Episode supported by our Partners, Device Technologies. -
Like very many countries around the world our friends in China are big fans of the EAU Guidelines, and are always tuned in when the updated Prostate Cancer Guidelines is released every year. So as part of our China Themed Episode Series, supported by our Gold Partners Bayer China, we are discussing some key updates to this year's Guideline with our China Editor Dr Yao Zhu (Shanghai) along with Dr Junlong Zhuang (Nanjing).
Even better on our Youtube channel
-
A bit of a break from the usual GU Oncology routine today folks! Declan was back at Guy's Hospital recently doing a talk and heard a remarkable story told by one of the Urology Fellows, Dr Joachim Jimie. A quite spectacular mid-air crisis, and some great life lessons in there also.
Declan could not resist the opportunity to grab Jimie and tell the tale again for GU Cast. Enjoy!!!
Even better on our YouTube channel
-
180 episodes later and Declan and Renu have cracked out the champagne in the GU Cast studio! Tune in for this quick pod with some reminiscing and some thank you's, especially to you our global audience!
-
Radiation cystitis! Now this can be a really challenging condition for urologists, and especially for patients, to manage and to live with. And we frequently struggle to get good results.
It is often years and years after radiation to the pelvis when patients return with problems like bleeding, pain, incontinence, fistula etc, which can have everything from minor, to ruinous effects on quality of life. And although these are radiation oncology patients, it is the urologist (and sometimes other surgeons) who have to manage these unfortunate side-effects of radiation.
Today we travel to London to chat with two Urologists at Guy’s Hospital who have set up a dedicated clinic to manage Radiation Cystitis patients from across the UK. Dr Ramesh Thurairaja and Dr Yasmin Abu Ghanem, explain why they set up this service, and share with us their strategy for assessing and managing radiation cystitis. This episode is full of useful advice for anyone out there managing radiation cystitis, and hopefully might inspire more people to set up similar clinics to look after these unfortunate patients.
Even better on our Youtube channel
Links:
Guy's Hospital Radiation Cystitis Clinic
Pelvic Radiation Disease Best Practice Pathway -
More great highlights from the recent EAU Annual Meeting in Madrid. Declan and Renu chat with Christian Gratzke, Sima Pore]ten, Yinjie Zhu, Rod Dunn, and have a most entertaining "pit lane walk" with Ben Challacombe around the various robots in the exhibition area.
GU Cast Conference Highlights are supported by our Conference Highlights Partner, Bayer China.
Even better on our YouTube channel -
Declan and Renu bring you some great highlights from the recent EAU Annual Meeting in Madrid. Hear from Laurie Klotz and Adam Kinnaird about the OPTIMUM RCT, Sarah Psutka and Laura Bukavina discuss their bladder cancer highlights, Riccardo Campi talks biomarkers, changes in practice and other highlights, and Rod van den Bergh and Eoin Dinneen debate the finer points of the NEUROSAFE Proof RCT.
GU Cast Conference Highlights are supported by our Conference Highlights Partner, Bayer China.
Even better on our YouTube channel
Links:
OPTIMUM paper in JAMA
Our Neurosafe podcast -
Really big prostate cancer news today with the release of very interesting results from the Neurosafe Proof trial at the EAU Annual Meeting in Madrid. Also simultaneously published in Lancet Oncology so this is a big deal!! In summary, this multi centre randomised trial from the UK demonstrates that men undergoing the Neurosafe technique (intra-operative assessment of surgical margins), had higher rates of nerve sparing surgery and this in turn led to improvements of recover of sexual function.
We were delighted to have a detailed discussion on this with key members of the University College London team who led this trial - Prof Greg Shaw, Dr Eoin Dinneen, and Dr Ricardo Almeida-Magana.This is a Themed Podcast supported by our Gold Partner, Mundipharma
Even better on our YouTube channelLinks:
Full paper in Lancet Oncology
Funders:
National Institute for Health Research
JP Poulton Charitable Foundation
Rosetree Trust
Orchid -
We are delighted to drop this pod just as the landmark TRANSLATE trial reads out at the EAU Annual Meeting in Madrid, with a simultaneous publication in Lancet Oncology. This is the world's largest trial of transrectal vs transperineal (TP) prostate biopsy, and reports that TP biopsy has superior cancer detection ability. Is this the end of the road for TRUS biopsy.
Hosts Declan Murphy and Renu Eapen are delighted to welcome first and senior authors, Prof Richard Bryant and Dr Alastair Lamb of the University of Oxford to have a detailed discussion about TRANSLATE and what this means for prostate biopsy.
`Even better on our YouTube channel
Links:
Lancet Oncology paper
Funders: -
Declan Murphy is in the GU Cast studio in Shanghai with GU Cast China Editor, Prof Yao Zhu. We sit down with Prof Hao Zeng (West China Hospital) and Dr Ye Yan to discuss their experiences and perspectives on advancements in diagnostics like MRI and PSMA PET, the increasing use of Chinese-developed robotic surgery platforms, and the ongoing debate surrounding pelvic lymph node dissection. They also address the application of systemic therapies for metastatic disease, considering the unique characteristics of the Chinese patient population and the potential for dose adjustments. Today's pod also highlights the growing importance of precision oncology, including genomic testing for mutations to guide treatment decisions, while acknowledging the challenges and future directions in this area.
This is a Themed Podcast supported by our Gold Partner, Bayer China.Even better on our YouTube channel https://youtu.be/xlOuS4swcuc
-
This week we had the great pleasure of attending the Annual Scientific Meeting of the Urological Society of Australia and New Zealand (USANZ), which took place in the beautiful city of Perth, far out on the West Coast of Australia. Not just that, but we spent a wonderful afternoon on one of Australia’s top tourist attractions, Rottnest Island. Tune in for plenty of quokka action!
Plus, of course we bring you some great conference highlights, chatting with international guests, including Laura Bukavina, Alberto Breda, Samir Taneja, plus Australian guests, Nathan Lawrentschuk, Michael Chamberlain, and Scientific Convener Trenton Barrett.
GU Cast conference highlights are brought to you by our Conference Highlights partner, Bayer China.
Even better on our YouTube channel (check out Rottnest Island and the Quokkas)!! - Laat meer zien
