Afleveringen
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Andrea Maier, Professor in Medicine and Director of the NUS Academy for Healthy Longevity at the National University of Singapore’s School of Medicine. They explore what the evidence shows on supplements, and why “test, then treat” beats guesswork.
Andrea unpacks a review of over 5 million people: multivitamins may support memory and lower systolic blood pressure in some older or at-risk groups, but offer little for healthy adults. She also reports lab audits of Nicotinamide Mononucleotide (NMN) and urolithin A, in which many products fell short of the label claims.
She then sorts buzzworthy compounds like alpha-ketoglutarate, spermidine, curcumin, and melatonin by mechanism, trial quality, and fit. Her rule stays simple: measure what you can, match the dose to the need, and track outcomes with walking speed, grip strength, steps, and wearable sleep data over time, not once.Guest-at-a-Glance
💡 Name: Dr. Andrea Maier
💡 What she does: Professor in Medicine, Healthy Ageing and Dementia Research, and Director of the NUS Academy for Healthy Longevity
💡 Company: the National University of Singapore’s School of Medicine
💡 Noteworthy: She runs human trials on supplements and aging, audits label accuracy in the lab, and pushes a “measure first” approach using biomarkers, wearables, and simple strength tests.
💡 Where to find her: https://www.linkedin.com/in/andreamaierprof
💡 Guest Company Website: https://discovery.nus.edu.sg/19564-andrea-britta-maierEpisode highlights:
[00:00:00]: Introduction
[00:01:02]: Overview of Evidence-Based Clinical Practice
[00:02:16]: Multivitamins and Minerals: Usage and Population Trends
[00:04:08]: Systematic Review Findings on Multivitamins and Cognitive Health
[00:05:44]: Who Benefits Most from Multivitamin Supplementation
[00:06:57]: Personalized Nutrition and the Case for Targeted Supplementation
[00:08:21]: Ongoing Clinical Trials on Multivitamins and Biological Age
[00:09:19]: Supplement Quality: Label Claims Versus Actual Content
[00:12:14]: Navigating Supplement Quality and Consumer Guidance
[00:14:53]: Novel Longevity Compounds: Alpha-Ketoglutarate
[00:17:47]: Alpha-Ketoglutarate: Human Evidence and Population Focus
[00:18:29]: Spermidine: Dietary Sources and Human Evidence
[00:21:25]: Curcumin: Mechanisms, Evidence, and Target Populations
[00:24:54]: Evaluating Supplements for Clinical Use
[00:27:08]: Scientific Approach to Supplement Research
[00:29:26]: The Role of Independent Research in Supplement Evaluation
[00:32:37]: Melatonin: Sleep, Jet Lag, and Circadian Rhythm
[00:37:25]: Practical Melatonin Use for Travel and Sleep Optimization
[00:41:05]: Digital Biomarkers: Definition and Emerging Role
[00:45:54]: Integrating Digital Biomarkers into Healthcare Practice
[00:49:05]: Physical Function Tests: Grip Strength and Sit-to-Stand
[00:59:48]: NAD Precursors: NMN, NR, and Human Trials
[01:05:23]: NAD Testing: Current Landscape and Future Directions
[01:07:24]: Final Takeaways and Closing RemarksFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Uri Alon, Professor at Weizmann Institute of Science. They explore a systems view of aging that treats longevity as a solvable model, not a grab bag of disconnected theories.
Uri explains aging with a simple story: houses make garbage, trucks remove it, and the village has a threshold for how much damage it can handle. In the body, “garbage” can include damaged and senescent cells, “trucks” can include immune cleanup, and “houses” can include long-lived cells and stem cells that drift over time. The model links this balance to death, disease, and steady decline, and it helps predict which interventions actually change it.
They also revisit the role of genes. Uri argues that lifespan looks closer to 50% heritable today after correcting for early, non-aging deaths in older datasets. The rest comes from the environment and biological noise, which regular sleep may help reduce.Guest-at-a-Glance
💡 Name: Dr. Uri Alon
💡 What they do: Professor of Molecular Cell Biology and systems biology researcher
💡 Company: Weizmann Institute of Science
💡 Noteworthy: He developed the network motifs framework and uses simple models to explain aging as a balance between damage, cleanup capacity, and robustness thresholds.
💡 Where to find him: https://www.linkedin.com/in/urialonw/Episode highlights:
[00:00:00]: Introduction
[00:01:41]: Transition from Physics to Biology and Systems Thinking
[00:03:06]: Systems Perspective vs. Traditional Biology
[00:03:45]: Theoretical Models and Patterns in Aging
[00:06:29]: Network Motifs and Biological Circuits
[00:10:26]: Applying Systems Biology to Aging and Healthspan
[00:12:27]: The Village Model: Framework for Understanding Aging
[00:19:24]: Interventions: Exercise, Robustness, and Lifespan Limits
[00:22:41]: Multi-level Modeling: From High-Level to Molecular Detail
[00:23:56]: Centenarians, Genetic Variants, and Disease Resistance
[00:25:26]: Menopause, Aging Genes, and Rare Variants
[00:26:57]: Heritability of Lifespan: Revisiting Twin Studies
[00:29:23]: Lifestyle, Genetics, and Diminishing Returns
[00:33:23]: Biological Noise, Environment, and Variability
[00:36:23]: Developmental Stochasticity and Lifespan Differences
[00:38:20]: Future Impact of Medicine on Genetic Influence
[00:40:36]: Polygenic Scores, Planning, and Public Perception
[00:41:25]: Genetic Circuits and Longevity Pathways
[00:44:22]: Epigenetic Reprogramming vs. Senolytics
[00:47:16]: Technological Readiness and Combining Interventions
[00:48:44]: Other Promising Interventions: Rapamycin, Engineering, and Targeted Approaches
[00:51:24]: GLP-1, SGLT2 Inhibitors, and Robustness
[00:53:01]: Vascular Health, Immune Function, and Lifespan Extension
[00:56:28]: Quick Fire Round: Myths, Principles, and Predictors
[00:59:04]: Key Takeaways: Systems View and the Equation of Aging
[01:02:07]: Closing Remarks and FarewellFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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Zijn er afleveringen die ontbreken?
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Paola Sebastiani, Professor of Biostatistics at Tufts Clinical and Translational Science Institute. They explore what centenarians reveal about reaching 100, and why there’s no single longevity gene.
Paola explains that studies keep finding many small genetic effects, which makes polygenic risk scores hard to use for personal prediction. She says progress depends on bigger cohorts and new analyses that include structural DNA changes and mitochondrial DNA. She also grounds the hype: for people born in 1900, only 0.2% of men and about 1% of women reached 100.
Guest-at-a-glance
Healthspan sits at the center of the story. Paola ties exceptional aging to delayed disease, lower inflammation, and biomarker profiles that stay more youthful. She highlights diet as a realistic lever, with centenarians showing stable, balanced eating, steadier protein intake, and metabolite signals linked to vegetables and dark chocolate.💡 Name: Dr. Paola Sebastiani
💡 What they do: Professor of Biostatistics
💡 Company: Tufts Clinical and Translational Science Institute
💡 Noteworthy: She analyzes genetic, proteomic, and metabolomic data from centenarians to map longevity signatures, with a focus on APOE, inflammation, and delayed onset of age-related disease.
💡 Where to find her: https://www.linkedin.com/in/paola-sebastiani-5973a646Episode highlights:
[00:00:00]: Introduction
[00:01:17]: Genetics and Longevity—Centenarian Studies
[00:03:17]: Genome-Wide Association Studies and Technological Advances
[00:04:20]: APOE, Genetic Variants, and Longevity Diversity
[00:05:58]: Polygenic Risk Scores and Longevity Prediction
[00:08:39]: Sample Sizes and Study Challenges in Longevity Research
[00:11:20]: Structural Variants, Mitochondrial DNA, and Data Sharing
[00:12:38]: Odds of Reaching Age 100—Historical Perspective
[00:15:22]: Healthspan, Compression of Morbidity, and Centenarian Quality of Life
[00:17:03]: Supercentenarians and Extreme Longevity
[00:21:02]: APOE Mechanisms, Inflammation, and Proteomic Signatures
[00:25:16]: Inflammation, Biomarkers, and Healthy Aging
[00:29:12]: Nutrition, Diet Balance, and Longevity
[00:32:28]: Food Versus Supplements—Practical Dietary Approaches
[00:35:02]: Molecular Profiles—Proteomics, Metabolomics, and Lipidomics
[00:39:01]: Gut Microbiome, Metabolomics, and Longevity Connections
[00:41:42]: Biological Pathways and Omics Insights in Centenarians
[00:45:01]: Protein Intake Patterns Across the Lifespan
[00:48:23]: Environmental Factors and Longevity
[00:50:18]: Physical Activity, Social Networks, and Objective Tracking
[00:53:45]: Offspring of Centenarians—Inheritance and Health Outcomes
[00:57:05]: Parental Longevity, Gender Differences, and Longevity Bias
[01:00:43]: Key Takeaways—Aging as a Positive Process
[01:03:25]: Closing Remarks and Episode Wrap-Up
[01:03:41]: End of EpisodeFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Terrie Moffitt, University Professor at Duke University. They explore the deep link between mental health, self-control, and the pace of biological aging, showing how early-life mental disorders can shape health decades later.
Terrie describes her work with the decades-long Dunedin study, which tracks health from birth through midlife. She explains how people age at different rates, even when born in the same year and place, and how the “pace of aging” can be measured using biomarkers. Terrie shares that fast agers show early signs of physical and cognitive decline, while those with strong self-control tend to experience better health, stronger relationships, and greater financial stability as they grow older.
The discussion reveals that treating mental health issues early in life could prevent chronic diseases and slow aging itself. Terrie makes a strong case for taking mental health seriously, both as prevention and as a path to a longer, healthier life.Guest-at-a-Glance
💡 Name: Dr. Terrie Moffitt
💡 What they do: University Professor
💡 Company: Duke University
💡 Noteworthy: Known for her research linking early-life mental health to aging, and for leading the Dunedin Study on human development, self-control, and healthspan.
💡 Guest Company Website: https://psychiatry.duke.edu/profile/terrie-e-moffittEpisode highlights:
[00:00:00]: Introduction
[00:00:36]: Overview of the Dunedin Study and Its Origins
[00:02:13]: Joining the Dunedin Study: Early Career and Risk-Taking
[00:04:35]: Transitioning the Dunedin Study to Aging Research
[00:07:52]: Dunedin Cohort Structure and Unique Features
[00:10:30]: Biological Samples and Longitudinal Data Collection
[00:10:52]: Concept of Pace of Aging vs. Chronological Age
[00:13:30]: Measuring and Modeling Pace of Aging
[00:14:45]: Validating Pace of Aging: Physical and Cognitive Effects
[00:16:27]: Environmental and Generational Controls in the Cohort
[00:18:25]: Early Onset of Aging Processes
[00:19:49]: Applying Pace of Aging to Other Populations
[00:20:59]: Making Pace of Aging Exportable: Epigenetics and Broader Use
[00:22:19]: Why the Longevity Industry Needs Pace of Aging Measures
[00:24:06]: Economic and Societal Impact of Extending Lifespan
[00:27:32]: Challenges in Changing Population Trends and Longevity Solutions
[00:28:07]: Testing Anti-Aging Interventions: Need for Surrogate Biomarkers
[00:31:28]: Surrogate Biomarkers and Clinical Trial Design for Aging
[00:32:04]: Self-Control as a Predictor of Health and Longevity
[00:35:11]: Self-Control in Childhood and Its Lifelong Impact
[00:36:39]: Mental Disorders and Their Link to Physical Health
[00:39:06]: Explaining the Mental Health–Aging Connection
[00:42:33]: Prevention Strategies for Healthspan and Mental Health
[00:48:59]: Population-Level Changes to Support Longevity
[00:56:01]: Rapid-Fire Questions: Behaviors and Habits for Longevity
[01:01:29]: Key Takeaway: Mental Health and Lifelong Impact
[01:02:44]: Closing Remarks and Episode Wrap-UpFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. David Allison, Director of the USDA Children’s Nutrition Research Center at Baylor College of Medicine. Together, they examine what it takes to build public trust in nutrition and longevity science, and why clear, reproducible evidence matters more than ever. David highlights how public perception and scientific rigor can drift apart, especially in fields crowded with strong opinions and shifting trends.
David shares sharp insights on weight management, challenging the idea that slow and steady always wins. He explains the “dentistry model” of weight loss, where maintenance matters more than one-time fixes, and explores why most people regain weight without ongoing support. The discussion cuts through assumptions about exercise, protein, and processed foods, showing where animal research aligns, or fails to align, with human studies.
Throughout, David pushes for honest communication and transparency in science. He urges listeners to question hype, look past nutrition fads, and recognize the real limits of current evidence. The episode offers practical wisdom for anyone who wants to approach health, nutrition, and longevity with both curiosity and caution.Guest-at-a-Glance
💡 Name: Dr. David Allison
💡 What he does: Director of the USDA Children’s Nutrition Research Center
💡 Company: Baylor College of Medicine
💡 Noteworthy: Known for advancing rigor and transparency in obesity and nutrition science, and for challenging assumptions in weight management, protein, and public health research.
💡 Where to find him: https://www.linkedin.com/in/david-allison-2917963b/Episode highlights:
[00:00:00]: Introduction
[00:00:53]: Background and Credentials
[00:02:17]: Importance of Reproducibility and Trust in Science
[00:06:50]: Defining Food Noise and Its Measurement
[00:10:01]: Biology, Environment, and Psychology of Food Noise
[00:13:18]: The Dentistry Model of Weight Management
[00:17:40]: Weight Cycling: Human and Mouse Studies
[00:21:19]: Long-Term Weight Loss Maintenance and Methods
[00:24:13]: Translating Animal and Observational Studies to Human Health
[00:29:18]: Exercise, Strength, and Longevity: Human and Animal Evidence
[00:34:50]: Exercise, Confounding, and Causal Inference
[00:35:57]: Exercise and Healthspan vs. Lifespan
[00:37:51]: Designing Experiments for Healthspan and Lifespan
[00:40:02]: Mendelian Randomization and Causality in Health Research
[00:41:40]: Protein Intake: Trends, Evidence, and Recommendations
[00:47:36]: Protein Needs for Special Populations
[00:50:57]: High Protein Diets, Amino Acids, and Longevity in Animal Models
[00:53:27]: Caloric Restriction and Lifespan Evidence
[00:55:22]: Full-Fat Dairy in Dietary Guidelines
[00:58:30]: Fermented Dairy and Health Outcomes
[01:01:07]: Processed Foods: Scientific and Practical Perspectives
[01:04:06]: Overrated Nutrition and Exercise Claims
[01:05:37]: Socioeconomic Status and Healthspan
[01:07:32]: Skepticism Toward Gut Microbiota Longevity Claims
[01:08:05]: Building Public Trust in Science and Closing RemarksFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Louise Hecker, Associate Professor of Medicine at Baylor College of Medicine. Together, they dive into Louise’s recent research exploring how psilocybin, the active compound in psychedelic mushrooms, may influence aging biology at the cellular and organismal level.
Louise shares the story behind her curiosity about psilocybin, sparked by conversations with a friend and fueled by a lack of scientific answers. She explains how her team overcame regulatory hurdles to study the effects of psilocybin on human cells and aging mice. Their findings showed that psilocybin extended cellular lifespan and reduced hallmarks of aging, such as oxidative stress and DNA damage. In mice, regular dosing improved survival, reversed visible signs of aging, and affected organs beyond the brain.
The conversation also covers the challenges of translating these findings into humans, the need for more research on dosing and safety, and the importance of funding in moving this field forward. Louise encourages listeners to stay curious, think beyond established paths, and keep an open mind as new questions and discoveries emerge in the science of aging.
Guest-at-a-Glance
💡 Name: Dr. Louise Hecker
💡 What they do: Associate Professor of Medicine
💡 Company: Baylor College of Medicine
💡 Guest Company Website: https://www.bcm.edu/people-search/louise-hecker-175346Link to the paper: https://www.nature.com/articles/s41514-025-00244-x
Episode highlights:
[00:00:00]: Introduction
[00:00:18]: Scientific Journey and Focus on Aging
[00:01:27]: Transition from Regeneration to Aging Research
[00:02:53]: Decline of Regeneration with Age
[00:03:43]: Motivation for Studying Psilocybin and Aging
[00:04:13]: Initial Curiosity and Literature Review on Psilocybin
[00:05:38]: Psilocybin’s Broad Clinical Applications
[00:06:19]: Hypothesis: Psilocybin’s Lasting Effects Linked to Aging
[00:07:14]: Defining Psilocybin and Its Effects
[00:08:25]: Legal Status and Research Barriers
[00:09:57]: Resurgence in Psilocybin Research and Regulatory Changes
[00:10:40]: Experimental Design: Dosing and Model Selection
[00:11:54]: Regulatory Hurdles in Acquiring Psilocybin
[00:13:08]: Initiating Experiments and Early Findings
[00:14:30]: Cellular Lifespan Extension Results
[00:15:17]: Quantifying Cellular Effects and Replication
[00:16:23]: Addressing Potential Cancer Concerns
[00:17:10]: Hallmarks of Aging and Cellular Markers
[00:18:44]: Telomere Length and DNA Protection
[00:19:52]: Organ-Specific Effects and Ongoing Research
[00:22:05]: Transition to Mouse Studies
[00:23:44]: Designing the Mouse Longevity Study
[00:26:28]: Results: Survival and Phenotypic Changes in Mice
[00:28:36]: Translating Mouse Findings to Humans
[00:30:09]: Next Steps: Dosing, Protocols, and Human Relevance
[00:32:26]: Omics Profiling and Organ-Specific Protection
[00:33:54]: Safety, Risks, and Human Studies
[00:35:13]: Comparing Psilocybin to Other Longevity Interventions
[00:37:00]: Implementation Challenges and Future Research Directions
[00:40:00]: Advice for Biohackers and Caution on Self-Experimentation
[00:42:29]: Funding, Research Priorities, and the Future of Psychedelic Research
[00:43:58]: Rapid-Fire Questions: Aging Misconceptions and Research Priorities
[00:46:11]: Social Connection and Long-Term Health
[00:48:50]: Key Takeaways and Closing Thoughts
[00:51:26]: Outro and FarewellFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Nathan Price, Professor and Co-Director at the Buck Institute for Research on Aging. Together, they explore how systems biology, artificial intelligence, and deep health data are changing the way we approach aging and prevention. Nathan explains why looking at single biomarkers falls short and why a network view of biology gives a clearer path to understanding disease and resilience.
Nathan shares how new tools, like genetics, proteomics, and the emerging field of digital twins, can help predict disease risk years in advance and guide more effective, personalized interventions. He also discusses how integrating data from wearables, blood tests, and the microbiome can help people move from reactive medicine to proactive health decisions, allowing for interventions that fit the individual.
The conversation highlights the promise and practical limits of current technologies, the trade-offs involved in optimizing health, and the power of AI to accelerate both research and personal health journeys. Nathan makes a strong case for the unique biology each person brings to the table and shows how the tools available today can help anyone take charge of their own healthspan in ways not possible before.
Guest-at-a-Glance💡 Name: Nathan Price
💡 What he does: Professor and Co-Director of the Center for Human Healthspan
💡 Company: Buck Institute for Research on Aging
💡 Noteworthy: Known for advancing systems biology and using AI and multi-omics to personalize health and healthspan interventions.
💡 Where to find him: https://www.linkedin.com/in/nathandpriceEpisode highlights:
[00:00:00]: Introduction
[00:00:49]: Overview of Systems Biology and Its Role in Health
[00:03:23]: Systems Biology vs. Reductionist Approaches
[00:04:28]: Systems Biology and the Shift from Treatment to Prevention
[00:06:29]: Defining Scientific Wellness
[00:08:52]: Early Detection of Disease with Omics and AI
[00:12:03]: Genetics and Early Risk Prediction
[00:15:18]: Polygenic Risk Scores and Population Diversity
[00:17:05]: Explaining Polygenic Risk Scores and Their Applications
[00:19:01]: Genetics, Lifestyle Interventions, and LDL Cholesterol
[00:20:51]: Integrating Multi-Omics Data for Personalized Health
[00:23:15]: AI Revolution in Health Data Analysis
[00:24:06]: Personalized Health Guidance and AI Agents
[00:27:15]: Scaling Scientific Discovery with AI
[00:32:23]: AI’s Impact on Healthspan and Personalized Recommendations
[00:34:47]: Human-AI Collaboration and Current Limitations
[00:36:23]: Accelerating Health Innovation and the Adjacent Possible
[00:38:36]: N-of-1 Experiments and Individualized Health Insights
[00:40:25]: Aggregating N-of-1 Data and Community Science
[00:42:54]: Digital Twins: Building Personalized Biological Models
[00:45:05]: Aging as a Network-Level Phenomenon
[00:49:43]: Trade-Offs in Aging and Optimizing Health Behaviors
[00:52:01]: Accessibility and Adoption of Omics Technologies
[00:55:39]: Pyramid of Health Data: From Dense Omics to Passive Measures
[00:59:28]: Rapid-Fire Questions and Key TakeawaysFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Ronjon Nag, Adjunct Professor in Genetics at Stanford School of Medicine and President of the R42 Group, for a wide-ranging conversation on how artificial intelligence is reshaping health, medicine, and longevity science.
Ronjon makes the case for systems thinking as a necessary framework for understanding aging, arguing that health emerges from complex interactions rather than isolated interventions. He explains how objective data—ranging from blood biomarkers to wearable-derived signals—can be integrated to guide better decisions, cut through conflicting health advice, and personalize interventions. The discussion also explores how AI is becoming a foundational tool, increasingly as ubiquitous as spreadsheets, enabling researchers, clinicians, and individuals to organize, connect, and interpret fragmented health data.
The conversation then turns to AI’s expanding role in drug discovery, personalized health insights, and ambitious efforts such as vaccines targeting aging biology. Along the way, Ronjon examines both the promise and the limitations of these approaches, emphasizing why interdisciplinary, data-driven methods—and clear thinking about causation, risk, and uncertainty—are essential for extending healthspan and improving long-term outcomes.
Guest-at-a-Glance💡 Name: Dr. Ronjon Nag
💡 What he does: Adjunct Professor in Genetics
💡 Company: Stanford School of Medicine, and the R42 Group
💡 Where to find him:https://www.linkedin.com/in/ronjonnagEpisode highlights:
[00:00:00]: Introduction
[00:06:40]: Lifelong learning and transition to teaching longevity science
[00:08:03]: Data science and AI in healthcare decision-making
[00:09:54]: Applying financial risk models to medical innovation
[00:11:52]: Venture investing in AI and longevity science
[00:13:29]: Inventing in aging, eye disease, and AI-driven life sciences
[00:15:48]: Impact of AI on the job market and computer science careers
[00:16:26]: Systems thinking in health and aging
[00:18:06]: Causation, correlation, and evidence in lifestyle science
[00:21:00]: Wearables, self-tracking, and feedback loops in health
[00:23:31]: Continuous health monitoring and behavioral change
[00:25:12]: Blood biomarkers as objective health feedback
[00:27:15]: AI’s future impact on biology, aging research, and lifespan
[00:29:03]: Language models, context windows, and the nature of AI intelligence
[00:32:03]: Empathy, ambition, and programming values into AI
[00:34:39]: Guardrails, regulation, and global risks of AI
[00:36:41]: Real-world applications of AI in health and longevity today
[00:39:13]: Integrating fragmented health data and building digital twins
[00:43:23]: Modeling human biology and the future of digital twins
[00:46:36]: AI limitations, hallucinations, and learning from mistakes
[00:48:14]: Risks and limitations of AI in healthcare and medicine
[00:51:13]: AI as collaborator for patients, clinicians, and scientists
[00:55:32]: Longevity ventures: vaccine for aging and food-based GLP-1
[01:09:38]: Fast food, processed foods, and public health
[01:10:03]: Rapid-fire: daily habits, overhyped interventions, and final advice
[01:16:59]: Closing remarks and episode wrap-upFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Wei-Wu, Executive Chairman at Human Longevity, Inc. Together, they explore how advances in genome sequencing, AI, and multi-layered diagnostics are changing the fight against age-related diseases. Wei-Wu shares why understanding your own genetic risks and combining them with other health data leads to better prevention and a longer healthspan.
Wei-Wu explains the value of integrating genome sequencing, advanced imaging, and liquid biopsy to catch diseases like cancer early, before symptoms appear. He draws on real-world examples, including how combining different tests can spot cancers that single methods might miss. The conversation highlights how technology brings down costs, making once-rare insights widely available, and how each person stands to benefit from personalized risk profiles.
The episode closes with practical advice: use today’s tools to become the CEO of your own health. Wei-Wu urges listeners to embrace data-driven, individualized care and stresses that no single tool or habit holds all the answers. Instead, true longevity comes from a holistic, ongoing approach, one that uses all available knowledge to prevent disease and extend both life and health.
Guest-at-a-Glance💡 Name: Dr. Wei-Wu
💡 What he does: Executive Chairman
💡 Company: Human Longevity, Inc.
💡 Noteworthy: Known for leading advances in genomics, precision medicine, and early disease detection by integrating AI, genome sequencing, and multi-omics data.
💡 Where to find him: https://www.linkedin.com/in/wei-wu-he-ph-d-he-him-b6957313/Episode highlights:
[00:00:00]: Introduction
[00:01:06]: Background in Genomics and Precision Medicine
[00:04:13]: Early Influences and Motivation for Longevity Research
[00:06:12]: Lessons from a Longevity Mentor
[00:08:11]: Academic Journey and Early Biomarker Research
[00:09:18]: Transition from Academia to Industry
[00:10:40]: Breakthroughs in Biomarker Approval and Commercialization
[00:11:15]: Connecting Genotype and Phenotype
[00:11:49]: Human Genome Sequencing: Cost and Innovation
[00:13:28]: Shotgun Sequencing and the Race to Decode the Genome
[00:14:39]: Linking Genes to Disease Risk
[00:15:39]: Advances in Genome Sequencing Technology
[00:16:56]: Biomarkers for Early Cancer Detection
[00:18:49]: Improving Prostate Cancer Detection with Multi-Modal Data
[00:20:30]: Personalized vs. Statistical Medicine
[00:22:11]: The Symphony of Longevity Care
[00:23:05]: Pap Smear and Cervical Cancer Screening
[00:24:39]: Vaccination and Cancer Prevention Progress
[00:26:00]: Global Disparities in Cancer Outcomes
[00:27:07]: Translating Scientific Breakthroughs to Population Health
[00:28:24]: The Value of Universal Genome Sequencing
[00:29:18]: Impact of Monogenic Diseases and Newborn Screening
[00:31:27]: Polygenic Risk Scores and Disease Prediction
[00:34:47]: Evolving Genomic Knowledge and Ongoing Discovery
[00:38:07]: The Case for Sequencing as a Lifelong Investment
[00:44:30]: Cancer Prevention and the Titanic Analogy
[00:50:08]: Multi-Modal Cancer Detection: Genetics, Imaging, and Liquid Biopsy
[00:57:24]: Advances and Limits of Genome Sequencing Technology
[00:58:10]: Liquid Biopsy for Early Cancer Detection
[01:01:28]: Integrating Data for High-Accuracy Cancer Prediction
[01:03:41]: Multi-Diagnostic Approach in Clinical Practice
[01:07:49]: Quick-Fire Round: Personal Biomarkers and Longevity Habits
[01:15:41]: The Myth of Single Solutions in Longevity
[01:15:51]: Embracing Data-Driven Longevity and AI
[01:19:59]: Closing Remarks and TakeawaysFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dalia Blander and Eprihm Blander, his parents, who are thriving in their nineties. Gil explores the daily routines, food choices, and mindsets that have kept Dalia and Eprihm active, independent, and healthy well into later life.
Dalia and Eprihm share how simple habits like regular movement, home-cooked meals, and a Mediterranean diet have shaped their health. They talk about the power of walking, gardening, and staying busy with meaningful work. Both value strong family ties and regular contact with friends, crediting these connections as key to their sense of purpose. Dalia highlights the importance of curiosity, reading, and keeping her mind sharp, while Eprihm stays engaged by helping with family business and learning new things.
Together, they show that a positive outlook, daily activity, and strong relationships are at the heart of a long, fulfilling life.Episode highlights:
[00:00:00]: Introduction
[00:01:04]: Episode Overview and Purpose
[00:01:50]: Guest Backgrounds
[00:02:45]: Approach to Interview and Method
[00:03:34]: Early Life and Childhood Environment
[00:04:17]: Childhood Diet and Physical Activity
[00:05:11]: Influence of Upbringing on Long-Term Health
[00:05:35]: Family Longevity and Genetic Background
[00:06:23]: Adult Life, Careers, and Daily Routines
[00:07:19]: Diet and Lifestyle in Adulthood
[00:07:43]: Attitudes Toward Health and Longevity
[00:08:31]: Habits Around Food, Sleep, and Exercise
[00:09:15]: Stress Management Approaches
[00:10:17]: Coping with Health Challenges and Positive Attitude
[00:11:37]: Daily Life and Routines in Their Nineties
[00:13:44]: Morning Routines and Keeping Active
[00:14:19]: Mental Engagement and Cognitive Health
[00:14:50]: Dietary Habits and Food Choices
[00:15:03]: Sources of Joy and Purpose
[00:15:27]: Mindset, Relationships, and Emotional Health
[00:16:38]: Social Connections and Family Importance
[00:17:01]: Role of Humor, Gratitude, and Curiosity
[00:17:35]: Attitude’s Impact on Health and Longevity
[00:17:58]: Advice for Younger Generations
[00:18:43]: Quick Fire Round: Daily Habits and Myths About Aging
[00:19:57]: Closing Reflections and Key Takeaways
[00:20:25]: Outro and FarewellFor science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
Similar Longevity By Design episodes we think you would love:
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Emeran Mayer, Executive Director at the UCLA Center for Neurobiology of Stress and Resilience and founder of Mayer Interconnected. They explore the science behind the gut-brain connection and its role in shaping health and longevity.
Emeran explains how signals flow between the brain, gut, and microbiome, influencing everything from digestion to emotions. He breaks down how modern diets, especially ultra-processed foods, disrupt the natural balance between humans and gut microbes—a relationship refined over thousands of years. The conversation highlights why early life exposure to antibiotics can have lasting effects on microbiome resilience, and how lifestyle choices like diet and exercise remain powerful tools for supporting gut-brain health at any age.
The discussion closes with a look toward the future of gut-brain science, including engineered probiotics and the promise of more targeted therapies. Emeran shares practical habits for better gut-brain health and cautions against quick-fix “biohacking,” encouraging a return to whole foods, movement, and mindful living.
Guest-at-a-Glance💡 Name: Emeran Mayer
💡 What he does: Executive Director and Founder
💡 Company: Mayer Interconnected
💡 Noteworthy: Internationally recognized for his research on the gut-brain-microbiome connection, with deep expertise in how diet, emotion, and microbes shape lifelong health.
💡 Where to find him: https://www.linkedin.com/in/emeranmayer/Episode highlights:
[00:00:00]: Introduction
[00:01:04]: Background in Gut–Brain Science
[00:03:04]: Early Influences and Career Path
[00:06:07]: Focus on Irritable Bowel Syndrome
[00:07:28]: Defining Irritable Bowel Syndrome
[00:08:40]: Evolving Understanding and Treatment of IBS
[00:10:22]: How the Gut and Brain Communicate
[00:13:32]: Sensation, Pain, and Visceral Hypersensitivity
[00:15:29]: Attention, Perception, and the Role of the Brain
[00:17:06]: Regulation of Sensitivity and Interventions
[00:18:25]: Bidirectional Brain–Gut System
[00:19:40]: Hormonal Signaling from Gut to Brain
[00:22:06]: Shared Biological Language of Gut, Brain, and Microbes
[00:24:08]: Microbiome’s Role in Gut–Brain Communication
[00:26:16]: Systems Biology and Complexity in Human Health
[00:29:01]: Evolution, Symbiosis, and Environmental Mismatch
[00:31:41]: Impact of Ultra-Processed Foods
[00:36:16]: Restoring Gut–Brain Health Through Diet and Lifestyle
[00:37:16]: Emotions and Their Effects on Gut Function
[00:42:03]: Antibiotics, Microbiome Resilience, and Early Life Impact
[00:46:25]: Aging, Microbiome, and Environmental Factors
[00:49:33]: Future Directions in Gut–Brain Science
[00:51:54]: Bioengineered Probiotics and Therapeutic Potential
[00:56:00]: Rapid Fire: Habits, Foods, and Beliefs for Gut–Brain Health
[01:00:31]: Closing Remarks and TakeawaysWe Appreciate You!
As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Albert-László Barabási, Professor at Northeastern University, to explore how networks shape health, aging, and nutrition. Barabási explains how biological and social networks influence resilience, robustness, and our ability to recover from stress or disease. He describes aging as a gradual loss of resilience, where the body becomes less able to bounce back from small disruptions.
The conversation moves into the world of nutrition, where Barabási introduces the concept of “nutritional dark matter.” He argues that food contains thousands of little-known molecules, many of which play key roles in health but remain largely unmapped and unstudied. Barabási breaks down how these compounds, especially those found in plants, support cellular function far beyond the traditional nutrients listed on food labels.
The episode closes with a look at ultra-processed foods and their link to disease risk. Barabási shares new research tools that can help people evaluate what they eat and make smarter choices. Throughout, he reminds listeners that strong connections, between cells, foods, and people, are at the heart of long, healthy lives.
Guest-at-a-Glance💡 Name: Albert-László Barabási
💡 What he does: Professor of Network Science
💡 Company: Northeastern University
💡 Noteworthy: Known for pioneering network science, the Barabási–Albert model, and research linking complex networks to human health, aging, and nutrition.
💡 Where to find him: https://www.linkedin.com/in/albert-laszlo-barabasi-264060165
💡 Guest Lab Website: https://barabasi.com/Episode highlights:
[00:00:00]: Introduction
[00:01:53]: Early Journey from Physics to Network Science
[00:02:57]: Statistical Physics and Complex Systems
[00:05:01]: Discovering Networks in Everyday Life
[00:07:19]: Network Medicine and Disease Spread
[00:08:28]: Robustness in Networks
[00:11:16]: Resilience in Networks and Real-World Systems
[00:14:31]: Biological and Ecological Examples of Resilience
[00:17:42]: Fixed Points, Tipping Points, and System Collapse
[00:18:45]: Applying Network Theory to Aging
[00:21:10]: Modeling Aging as Loss of Resilience
[00:23:02]: Explaining the Resilience Framework for Aging
[00:26:09]: Disease, Aging, and System Perturbations
[00:27:43]: Lifestyle Factors and Biological Age
[00:29:19]: Epigenetic Reprogramming and Longevity Potential
[00:33:41]: Nutrition, Food Networks, and Nutritional Dark Matter
[00:34:41]: Mapping Food Molecules and Network Medicine
[00:38:02]: Polyphenols and the Role of Plant Chemicals
[00:42:14]: Cataloging Food Chemistry and the Need for a Food Genome Project
[00:44:57]: Food Molecules as Drug Candidates
[00:48:38]: Ultra-Processed Foods and Health Risks
[00:53:54]: Measuring and Identifying Ultra-Processed Foods
[00:57:55]: Comparing Food Processing Methods
[01:02:26]: Rapid-Fire Questions: Network Concepts, Diet, and Longevity
[01:07:18]: Key Takeaway and Closing RemarksWe Appreciate You!
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In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Kerry Burnight, Gerontologist, Chief Gerontologist, New York Times best-selling author, and researcher. They explore what it truly means to age well, focusing less on resisting the passage of time and more on embracing vitality, curiosity, and joy throughout life’s second half.
Dr. Burnight explains why the common “decline” mindset around aging misses the full story. She shares research showing that meaningful growth, strong social connections, adaptability, and a sense of giving can shape both how long and how well we live. Dr. Burnight offers practical examples for building these habits, from maintaining friendships across generations to finding purpose in everyday acts.
Throughout the conversation, Dr. Burnight urges listeners to rethink their beliefs about aging and to prepare for later life with intention. She shows that nurturing joy and purpose is just as important as physical health, and that everyone can take steps to build a more satisfying, resilient, and joyful future.
Guest-at-a-Glance💡 Name: Dr. Kerry Burnight
💡 What she does: Chief Gerontologist
💡 Website: https://www.hachettebookgroup.com/contributor/dr-kerry-burnight-ph-d/
💡 Noteworthy: Known for advancing the science of healthy aging and creating practical tools for older adults to thrive with joy, purpose, and connection.Episode highlights:
[00:00:00]: Introduction
[00:01:16]: Overview of Gerontology and Professional Background
[00:04:52]: Defining Gerontology and Its Distinction from Geriatrics
[00:05:39]: Evolving Perspectives on Aging
[00:06:47]: Early Intervention and Preparing for Aging
[00:08:13]: Respect for Older Adults and Shifting Attitudes Toward Age
[00:09:11]: Challenging the Decline Mindset of Aging
[00:10:40]: Positive Aspects of Aging and Societal Value
[00:12:13]: Demographic Trends and the Value of Centenarians
[00:12:51]: Rethinking Longevity: Quality Versus Quantity of Life
[00:14:17]: Introducing Joyspan and Differentiating Lifespan, Healthspan, and Joyspan
[00:16:56]: Linking Joy, Purpose, and Longevity
[00:17:51]: The Four Pillars of Thriving Longevity
[00:19:53]: Growth Beyond Retirement and Lifelong Learning
[00:20:22]: The Importance of Social Connection
[00:21:37]: Work, Retirement, and Finding Purpose Post-Career
[00:23:24]: Planning for Retirement and Staying Engaged
[00:25:37]: Diversifying Social Circles Across Ages
[00:26:29]: Overcoming Ageism and Fostering Intergenerational Friendships
[00:29:25]: Adaptation as a Key to Aging Well
[00:33:47]: Giving and Finding Purpose Through Contribution
[00:36:26]: Real-Life Example: Rebuilding Life After Loss
[00:41:20]: Cultural Narratives and Internalized Ageism
[00:44:34]: Policy, Healthcare, and Intergenerational Solutions
[00:46:41]: Economic Realities and Social Determinants of Healthy Aging
[00:50:03]: Daily Joy Practices and the Power of Gratitude
[00:53:15]: Visualizing a Positive Future Self
[00:54:47]: Key Takeaway: Integrating Internal and Physical Health for Longevity
[00:55:31]: Closing Remarks and ResourcesWe Appreciate You!
As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
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In this episode of Longevity by Design, host Gil Blander sits down with Florence Comite, MD, physician-scientist and founder of the Comite Center for Precision Medicine & Healthy Longevity. They explore why a one-size-fits-all approach to longevity falls short and how personalized data, from biomarkers to genetics, can spot early signs of disease before symptoms appear.
Florence explains her “Nof1” method, which uses deep testing, wearables, and personal history to craft precise health plans. She highlights how sleep, more than exercise or diet, shapes long-term health but remains hard for most people to optimize. Using real-world examples, Florence shows why tracking markers like insulin and hormones matter, and why most people need support to turn health knowledge into action.
The conversation covers the limits of standard medical care, the value of knowing your family history, and how even the best routines must adapt over time. Florence urges listeners to get curious about their own data and take steps—however small—toward better health.
Guest-at-a-Glance💡 Name: Dr. Florence Comite
💡 What she does: Physician-scientist and innovator
💡 Company: Comite Center for Precision Medicine & Healthy Longevity
💡 Noteworthy: Known for pioneering “Nof1™” precision medicine, integrating genomics, biomarkers, and lifestyle data to prevent and delay chronic disease and optimize healthspan.
💡 Guest Company Website: https://www.comitemd.com/Episode highlights:
[00:00:00]: Introduction
[00:01:00]: Sleep vs. Exercise in Health Priorities
[00:02:00]: Background and Shift from Conventional to Proactive Medicine
[00:04:00]: Early Epiphanies on Aging and Metabolic Decline
[00:06:00]: Connecting Data Across Systems and the Limits of One-Size-Fits-All
[00:08:00]: Family Variability and the Case for Individualized Care
[00:10:00]: Genetics, Environment, and the Impact of Lifestyle
[00:11:00]: Challenges in Applying Genomic Data in Medicine
[00:12:00]: Nof1™ Protocols and Personalized Data Collection
[00:14:00]: Baseline Assessments and Biomarker Analysis
[00:16:00]: Holistic Approach to Patient Assessment
[00:17:00]: Importance of VO2 Max and Endurance for Healthspan
[00:18:00]: Early Detection and Intervention in Children and Adults
[00:19:00]: Insulin, Glucose, and Overlooked Markers in Pre-Diabetes
[00:20:00]: Evolutionary Perspective on Metabolic Disease
[00:21:00]: Moderation, Wearables, and the Promise of Digital Health
[00:22:00]: Behavioral Barriers to Lifestyle Change
[00:23:00]: Wearables, Real-Time Feedback, and Democratizing Health Data
[00:24:00]: Drivers of Chronic Disease and the Role of Genetics
[00:27:00]: Lifestyle Interventions That Move the Needle
[00:28:00]: Sleep as a Foundational Health Variable
[00:30:00]: Strategies for Improving Sleep Quality
[00:33:00]: Personalized Sleep Optimization and Barriers for the General Public
[00:36:00]: Hormonal Changes, HRT, and Gender Differences in Aging
[00:44:00]: Longevity Myths and the Limits of Universal Advice
[00:47:00]: Genetics, Data, and Playing the Best Hand
[00:51:00]: Using Family History and Genetic Insights for Prevention
[00:52:00]: Book Preview: Prototypes and Personalization
[00:55:00]: Key Biomarkers and the Value of Actionable Advice
[00:56:00]: Integrating AI and Automation in Precision Medicine
[00:59:00]: Final Thoughts and Practical Wisdom
[01:00:00]: Closing Remarks and ResourcesWe Appreciate You!
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In this episode of Longevity by Design, our host, Dr. Gil Blander, sits down with Dylan Livingston, CEO at the Alliance for Longevity Initiatives, and Dr. Brenda Eap to explore how public policy shapes the future of aging research. Dylan and Brendan share how their team pushes for legislation that supports healthy lifespan extension, aiming to bring longevity science into the center of national health priorities.
Dylan and Brendan explain why policy advocacy is crucial for securing funding for research, reducing regulatory hurdles, and establishing a clear path for new therapies. They outline recent successes, including building bipartisan support in Congress and expanding access to experimental treatments in states such as Montana. Throughout their discussion, Dylan shows how effective communication, using stories and simple analogies, helps move longevity from the lab to lawmakers’ agendas.
The episode closes with practical advice for listeners. Dylan highlights the power of community, clear communication, and grassroots action as tools that help turn advanced science into real-world health gains.Episode highlights:
[00:00:00]: Introduction
[00:01:00]: Overview of Longevity Policy and Research Funding
[00:02:00]: Backgrounds and Personal Journeys into Longevity Advocacy
[00:05:00]: Inspiration and Founding of Longevity Policy Organization
[00:07:00]: Scientific Training and Motivation for Policy Work
[00:09:00]: Mission and Approach of Longevity Advocacy Organization
[00:10:00]: Policy Advocacy’s Role in Advancing Longevity Research
[00:12:00]: Gaps in Funding and the Importance of Government Engagement
[00:13:00]: Experiences with Policy Events and Realizations about Advocacy
[00:14:00]: Early Accomplishments and Congressional Engagement
[00:15:00]: Building Bipartisan Support and the Longevity Science Caucus
[00:16:00]: Legislative Engagement and Policy Paper Development
[00:17:00]: State-Level Policy Wins and Expansion of Right to Try Laws
[00:19:00]: Rationale and Strategy for State-Level Focus
[00:21:00]: Plans for Geographic Expansion of Longevity Policy Initiatives
[00:23:00]: Political Climate and Opportunities with the Current Administration
[00:25:00]: Shifts in Federal Attitudes Toward Longevity and Healthspan
[00:27:00]: Demographics, Policy Momentum, and National Health Priorities
[00:29:00]: Prevention Versus Treatment: Shifting Policy Mindsets
[00:32:00]: Communicating Policy Opportunities to a Wider Audience
[00:34:00]: Ensuring Longevity Policy Remains Bipartisan
[00:35:00]: Intersection of Policy, Science, and Public Engagement
[00:37:00]: Funding and Regulatory Challenges in Longevity Research
[00:39:00]: Barriers in Clinical Trials and Policy Modernization
[00:40:00]: Strategies for Communicating Longevity Science to Policymakers
[00:44:00]: Framing Longevity for Policy Impact and Public Understanding
[00:48:00]: Future Vision and Milestones for Longevity Policy
[00:51:00]: How Individuals and Organizations Can Support Longevity Advocacy
[00:55:00]: Practical Longevity Advice and Episode ConclusionWe Appreciate You!
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Aging is more than disease—it’s the steady decline of function. In this episode of Longevity by Design, Dr. Gil Blander speaks with physicist-turned-biotech innovator Dr. Peter Fedichev about why resilience, not diseases, holds the key to longer lives.
Peter explains how his background in theoretical physics shaped his approach to biology and aging. He outlines why startups, not large institutions, are now leading innovation in longevity science. Drawing from physics, he describes aging as a series of “jumps” between states, each leaving the body more fragile.
The discussion moves from the limits of current drugs to the promise of new approaches. Peter argues that reducing fluctuations and increasing molecular fidelity could unlock far greater gains in healthspan and lifespan. Listeners gain a fresh lens on what drives aging, where the real breakthroughs may come from, and why the next frontier in longevity will require rethinking the problem altogether.Guest-at-a-Glance
💡 Name: Peter Fedichev
💡 What they do: Founder & CEO
💡 Company: Gero (biotech company using AI to study aging)
💡 Noteworthy: Physicist turned biotech leader applying statistical physics to model biological age and resilience
💡 Where to find them: LinkedIn
Episode highlights:
[00:00:00] Opening Thoughts on Venture Capital
[00:00:58] Host Introduction and Show Welcome
[00:01:25] Guest Background: From Physics to Biotech
[00:02:42] Physics as a Tool for Biology
[00:05:19] Why Switch From Physics to Biology
[00:06:20] Discovering Aging Through Naked Mole Rats
[00:09:27] Defining Professional Goal in Aging
[00:10:15] Challenges in Crossing Disciplines
[00:11:58] Startups Driving Scientific Innovation
[00:14:09] Pharma, Biotech, and Market Dynamics
[00:16:23] Aging as a System-Level Problem
[00:18:56] Drugs With Modest Longevity Effects
[00:20:14] Aging vs. Disease: Functional Decline
[00:23:48] Squaring the Curve vs. True Aging
[00:26:02] Sponsor Message: InsideTracker
[00:26:56] Resilience in 90-Year-Olds
[00:27:55] Measuring Health With Longitudinal Data
[00:30:07] Aging as Jumps Between States
[00:31:49] Declining Recovery Times With Age
[00:33:33] Cancer Risk and Immune Decline
[00:34:30] Rare Events Driving Aging Jumps
[00:36:15] Mutations, Epimutations, and Reliability Theory
[00:38:31] Perfect Storm Failures in Aging
[00:40:26] Cancer, Diabetes, and System Crashes
[00:42:09] Searching for a Master Switch
[00:43:41] Reducing Physiological Noise to Slow Aging
[00:45:54] Targeting Fluctuations as Drug Strategy
[00:47:13] Stress, Hormesis, and Adaptation
[00:49:27] Evolutionary Role of Stress Responses
[00:50:58] Model Organisms: Mice vs. Dogs
[00:53:41] Why Dogs Mirror Human Aging
[00:55:42] Regulatory Edge: Aging Trials in Dogs
[00:56:42] Next-Gen Drugs Beyond GLP-1
[00:58:22] Epigenetic Rejuvenation vs. Noise Control
[01:00:11] Key Targets: Chromatin Modifiers
[01:01:10] Measuring Fluctuations With Biomarkers
[01:02:58] Dogs as Proof-of-Concept Model
[01:03:23] Defining Jumps Through Omics DataWe Appreciate You!
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In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging. Eric discusses the science behind therapeutic plasma exchange (TPE) and its potential to slow biological aging in humans. The conversation explores findings from a recent clinical trial, including measurable age reversal using epigenetic clocks.
Eric explains how removing and replacing plasma can dilute pro-aging factors in the blood, a concept inspired by earlier animal studies on parabiosis. He also describes why rigorous, placebo-controlled human trials are crucial for validating longevity interventions and distinguishing the field from hype-driven wellness trends.
The episode also highlights how omics data, such as metabolomics and proteomics, are shaping a new era of precision aging research. Eric emphasizes the value of lifestyle interventions as a foundation and sees future opportunities in combining TPE with personalized strategies to extend healthspan.Guest-at-a-Glance
💡 Name: Dr. Eric Verdin
💡 What they do: President and CEO
💡 Company: Buck Institute for Research on Aging
💡 Noteworthy: Physician-scientist pioneering human aging research through epigenetics, metabolism, and translational science.
💡 Where to find him: LinkedIn
Episode highlights:
[00:00] Introduction to Longevity and Healthspan
[01:07] Meet Dr. Eric Verde: A Pioneer in Aging Research
[02:24] Exploring Therapeutic Plasma Exchange
[03:08] The Science Behind Heterochronic Parabiosis
[07:17] Clinical Trials and Methodologies
[12:58] The Role of Omics in Precision Medicine
[17:20] Epigenetic Clocks and Aging
[22:04] Therapeutic Plasma Exchange: Results and Implications
[26:22] Exploring Frequency and Efficacy of Treatments
[28:23] Biomarkers and Predictive Models
[31:33] Safety Profile and Side Effects
[33:28] Intrinsic Capacity and Aging Metrics
[36:58] Combining Treatments with Lifestyle Changes
[44:26] Future Directions and Recommendations
[49:08] Conclusion and Final ThoughtsWe Appreciate You!
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In this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Keith Diaz, Associate Professor of Behavioral Medicine at Columbia University Irving Medical Center, to unpack the hidden health risks of prolonged sitting.
Keith explains why even daily exercise isn't enough to counteract the effects of sedentary behavior. Drawing on his lab's findings, he shares a simple but powerful prescription: five minutes of light walking every hour. That small change can lower blood pressure, improve mood, and reduce fatigue, without needing to break a sweat.
The conversation also explores how modern work and home environments are built around sitting, and what it takes to build smarter habits. From treadmill desks to family walks, Keith offers practical strategies that make movement part of everyday life. Whether you're an employer, a clinician, or just desk-bound, this episode helps you rethink how you move through your day.Guest-at-a-Glance
💡 Name: Dr. Keith Diaz
💡 What they do: Associate Professor
💡 Company: Columbia University Irving Medical Center
💡 Noteworthy: Leading researcher on sedentary behavior, cardiovascular health, and wearable tech in clinical care.
💡 Where to find them:LinkedIn
Episode highlights:
[00:00:00] Introduction: The Evolution of Television Viewing Habits
[00:00:23] Welcome to Longevity By Design
[00:00:33] Introducing Dr. Ki Diaz
[00:02:14] The Impact of Sedentary Behavior
[00:04:23] The Physiology of Sitting
[00:09:59] Exercise vs. Sedentary Lifestyle
[00:16:56] Movement Breaks: How Short is Beneficial?
[00:27:45] The Role of Wearable Devices
[00:31:51] Integrating Movement into Daily Routines
[00:33:34] Behavioral Changes and Personal Strategies
[00:34:55] The Benefits of Movement Breaks at Work
[00:37:26] Wearables and Their Impact on Health
[00:40:16] Clinicians' Role in Promoting Movement
[00:43:09] Tailoring Movement to Individual Lifestyles
[00:47:28] Incentives for Employers and Insurers
[00:52:46] Personal Movement Hacks and Daily Routines
[00:58:16] Future Research and Final ThoughtsWe Appreciate You!
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In this episode, Dr. Gil Blander welcomes Dr. Haim Cohen to Longevity by Design to explore his revolutionary approach to understanding aging. Haim's team analyzed acetylation sites across 107 mammalian species, creating its most extensive comparative study. This computational approach revealed specific post-translational modifications that evolved exclusively in long-lived animals.
The research identifies critical pathways where evolution engineered longevity solutions. These acetylation changes affect DNA repair, cell cycle regulation, and mitochondrial function. Unlike traditional aging research focusing on single pathways like mTOR or caloric restriction, Haim's unbiased screening simultaneously reveals multiple longevity targets. Evolution provided a natural laboratory for testing anti-aging modifications over millions of years.
The findings offer exciting therapeutic possibilities for human longevity. Haim's team is now creating transgenic mice to test whether mimicking these evolutionary changes can extend lifespan in the lab. This research suggests humans could potentially "accelerate evolution" by implementing modifications that nature has already proven effective in whales, elephants, and other long-lived species.Guest-at-a-Glance
💡 Name: Dr. Haim Cohen
💡 What they do: Professor of Molecular Genetics focused on the biology of aging
💡 Institution(s): Bar-Ilan University (Israel); Founder & Director, Minerva Israel-Germany Center forBiological Mechanisms of Aging; Founder & Director, Sagol Center for Human Health and Longevity💡 Noteworthy: Global leader in aging research; author of 75+ peer-reviewed papers, including work showing SIRT6 over-expression can extend mouse lifespan by ~30 percent
💡 Where to find them: Bar-Ilan University faculty pageEpisode highlights:
[00:00:00] Introduction
[00:01:00] Dr. Haim Cohen background and SIRT6 research update
[00:05:50] Gender-specific effects in aging research
[00:07:40] Introduction to the groundbreaking Nature paper on acetylation
[00:08:30] What is acetylation and why study it
[00:11:40] Study design across 107 mammalian species
[00:15:00] Using evolution as a research laboratory
[00:19:00] Key findings and statistical approach
[00:28:00] Validating specific proteins - CBS and hydrogen sulfide
[00:31:30] Mitochondrial acetylation and metabolism
[00:34:10] DNA repair pathways and the Peto Paradox
[00:35:00] Cancer prevention mechanisms in large animals
[00:38:30] P53 tumor suppressor conservation
[00:40:50] Cat family longevity anomaly
[00:42:10] Therapeutic implications and drug development
[00:45:00] Targeting proteins versus modifications
[00:47:40] Study limitations and future validation
[00:49:20] Comparing effects to existing longevity interventions
[00:51:00] Implications for human longevity
[00:55:00] Dr. Cohen's top tip for longevity
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On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Karl Pfleger, aging biotechnology investor and creator of AgingBiotech.info, to dissect the rapidly evolving field of aging therapeutics. Karl breaks down the sector into two main categories: interventions that slow aging rates versus rejuvenation strategies that repair accumulated damage.
Karl highlights the most promising areas in his investment portfolio, including senolytics for clearing senescent cells and epigenetic reprogramming technologies. He explains why current aging clocks aren't ready for clinical use and discusses the limitations of popular interventions like GLP-1 drugs and fasting protocols. The conversation reveals that 14 Phase 3 clinical trials are currently testing core aging therapeutics.
The discussion covers recent FDA approvals for ATTR treatments and stem cell therapies, signaling the field's maturation. Karl emphasizes that meaningful life extension requires a "divide and conquer" strategy, targeting multiple aging mechanisms simultaneously rather than relying on single interventions. Despite exciting therapeutic developments, he maintains that optimizing diet, exercise, and sleep remains the most impactful strategy for extending healthspan today.Guest-at-a-Glance
💡 Name: Dr. Karl Pfleger
💡 What they do: Angel investor, philanthropist, and advocate in aging and longevity biotechnology
💡 Institution(s): Creator and maintainer of AgingBiotech.info (comprehensive public database of 400+ aging companies)
💡 Noteworthy: Exclusively invests in aging/longevity sector with 15+ portfolio companies targeting damage repair approaches
💡 Where to find them: LinkedIn | AgingBiotech.info | X (Twitter)
Episode highlights:
00:00:00 Introduction to GLP-1 Drugs and Their Impact
00:00:56 Meet Dr. Karl Pfleger: A Pioneer in Aging and Longevity
00:02:50 Karl Pfleger's Journey from Tech to Aging Biology
00:05:18 The Current State of Longevity Biotech
00:09:47 Exciting Developments in Rejuvenation Biotechnology
00:24:17 Aging Biotech Info: A Comprehensive Resource
00:31:59 Future Plans for Aging Biotech Info
00:36:51 The Obesity Revolution: GLP-1 Receptor Agonists
00:40:29 Global Obesity Rates and GLP-1 Drugs
00:40:43 Potential Benefits and Limitations of GLP-1 Drugs
00:42:13 Muscle Atrophy and Side Effects of GLP-1 Drugs
00:44:12 Emerging Muscle Aging Treatments
00:46:10 Biotech Companies and Obesity Programs
00:46:53 Public vs. Private Biotech Companies
00:49:12 Fasting and Calorie Restriction
00:55:20 Blood Transfusions and Parabiosis
00:58:09 Metformin and N-of-1 Experiments
00:59:13 Comprehensive Aging Interventions
01:03:54 Diagnostics and Aging Clocks
01:13:49 Future of Aging Interventions
01:16:07 Top Tips for Health and LongevityWe Appreciate You!
As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast - Laat meer zien
