Afleveringen
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Not all medical research is created equal, so how do we know which studies to trust?
The phrase evidence-based medicine (EBM) is often misunderstood and misused. What does it truly mean to rely on evidence in clinical decision-making?
Dr. Gordon Guyatt, the father of the term evidence-based medicine, explains how to assess scientific studies, understand the strength of different types of evidence, and apply findings to clinical decisions.
Want to make better-informed health decisions? This interview will help you learn how to critically assess medical evidence for yourself. In this conversation, Dr. Guyatt breaks down:
✅ Why some studies are more trustworthy than others✅ The limitations of observational studies in nutrition and medicine✅ How the GRADE framework categorizes evidence from high to low certainty
✅ How to critically assess nutrition and mental health research
✅ The importance of patient values in clinical decision-making
As new chronic disease treatments emerge from rapidly evolving research, understanding the quality of evidence is more important than ever. The ability to distinguish robust data from weak correlations isn’t just a skill—it’s essential for making informed, effective decisions in patient care.
#MetabolicMind #EvidenceBasedMedicine #MedicalResearch #NutritionScience #GRADEMethod #HealthDecisions
Expert Featured:
Dr. Gordon Guyatt, MD
Resources Mentioned:
Core GRADE Workshop
CMEs Mentioned:
Managing Major Mental Illness with Dietary Change: The New Science of Hope
https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616Brain Energy: The Metabolic Theory of Mental Illness
https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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Can the ketogenic diet help kids with bipolar disorder? We are excited to announce new research is finally exploring this question.
The ketogenic diet was first discovered over 100 years ago for children with epilepsy. Could ketogenic therapy also improve mental health outcomes for youth with serious conditions like bipolar disorder? Dr. Kirk Nylen joins Dr. Bret Scher to discuss two groundbreaking studies underway that are tackling this question head-on.
In this episode, they dive into:
🔬 The Child and Adolescent Bipolar Network (CABIN) study – a multi-site RCT testing ketogenic therapy in pediatric bipolar disorder
🏥 Children’s Mental Health Resource Center (CMHRC) study – A real-world pilot study exploring the practical application of ketogenic interventions for kids with bipolar
🛠️ How data emerging from these studies could add new tools to clinicians' toolboxes
As the youth mental health epidemic continues to rise, we must continue to pursue better solutions. We are hopeful that this research will not only expand treatment options but also inspire more pediatric clinicians to consider the powerful role ketogenic therapy can play in improving mental health outcomes for children.
Expert Featured:
Dr. Kirk Nylen, PhD
Managing Director of Neuroscience as Baszucki Group
Resources Mentioned
Children’s Mental Health Resource Center
https://cmhrc.orgCMEs Mentioned
Managing Major Mental Illness with Dietary Change: The New Science of Hope
https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616Brain Energy: The Metabolic Theory of Mental Illness
https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
Timestamps:
0:00 - Introduction to ketogenic interventions for pediatrics and Kirk Nylen, PhD.2:17 - The history of ketogenic therapies in pediatrics. How safe are ketogenic therapies for children?6:37 - Bipolar study on children: background of the Child Bipolar Network study. How are they testing and what are they looking for?10:11 - How does the Children’s Mental Health Resource Center address the gaps in pediatric bipolar research?13:25 - Summary of the state of research on ketogenic therapies for bipolar in children and what questions remain. -
Zijn er afleveringen die ontbreken?
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Can you safely taper off psychiatric medications? And what are the potential harms of long-term psychiatric care?
Laura Delano spent years as a professional patient, navigating psychiatric diagnoses, multiple medications, and a life defined by treatment.
In this interview, Laura discusses her 13-year experience as a psychiatric patient, the impact of long-term medication use, and how she took control of her health to successfully taper off multiple psychiatric drugs.
Now, as the founder of Inner Compass Initiative and author of Unshrunk: A Story of Psychiatric Treatment Resistance (available March 18, 2025), she’s dedicated to helping others navigate informed choices about psychiatric medications, diagnoses, and withdrawal.
💡 In this episode, we cover:
✅ Laura’s personal story of polypharmacy and its effects
✅ The impact of long-term psychiatric medication
✅ The challenges of tapering and withdrawal
✅ How Laura has rebuilt her life beyond medications
✅ How Laura built a nonprofit to support others on the same path
✅ The role of diet, lifestyle, and community in mental health recovery
✅ Why informed consent is crucial for psychiatric treatment decisions
✅ The mission of Inner Compass Initiative
Laura’s new book Unshrunk: A Story of Psychiatric Treatment Resistance is available March 18, 2025.
⚠️ Trigger Warning: This conversation includes discussion of suicidality and a suicide attempt. Please take care when watching.
#MentalHealth #Psychiatry #Deprescribing #PsychiatricMedication #Tapering #MetabolicPsychiatry
Expert Featured:
Laura Delano
Resources Mentioned:
Inner Compass Initiative
https://www.theinnercompass.org/Laura’a New Book: Unshrunk: A Story of Psychiatric Treatment Resistance
https://www.amazon.com/Unshrunk-Story-Psychiatric-Treatment-Resistance/dp/1984880489The Challenges of Going off Psychiatric Drugs
https://www.newyorker.com/magazine/2019/04/08/the-challenge-of-going-off-psychiatric-drugsCMEs Mentioned:
Managing Major Mental Illness with Dietary Change: The New Science of Hope
https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616Brain Energy: The Metabolic Theory of Mental Illness
https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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Brain Energy and metabolism appear to play critical roles in the development and treatment of psychiatric disorders like bipolar disorder, depression, and schizophrenia. And emerging research suggests that our gene expression influences how our brain uses energy, thus linking the fields of genetics and metabolism.
In this episode, Dr. Harry Pantazopoulos, Associate Professor in the Department of Psychiatry and Human Behavior at the University of Mississippi Medical Center, joins Dr. Bret Scher to discuss fascinating new research into the relationship between gene expression and metabolism in serious mental illness.
Dr. Pantazopoulos’ study reveals a fascinating insight: while metabolic dysfunction is a common feature of serious mental illnesses, each condition exhibits its own distinct patterns of altered gene expression that impacts metabolic function. This suggests that the underlying metabolic dysfunction in mental illness arises through different mechanisms unique to each disorder.
In this interview you will learn:
The benefits of studying metabolic function and gene expression of the amygdala Which genes show altered expression in each mental illness, and how these changes affect metabolism How shifting the brain’s energy source from glucose to ketones could offer a promising way to address changes in metabolic gene expression How these study findings could translate to targeted clinical care
Although these findings are not yet ready to directly influence clinical psychiatric care models, they provide a critical foundation for future research aimed at tailoring metabolic therapies to the unique needs of each individual.
Expert Featured:
Harry Pantazopoulos, MD
LinkedIn: https://www.linkedin.com/in/harry-pantazopoulos-04460413/
X: @HarryPantazopo1
Studies Mentioned:
Transcriptomic Analysis of the Amygdala in Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder Reveals Differentially Altered Metabolic Pathways
Differentially Altered Metabolic Pathways in the Amygdala of Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder
CMEs Mentioned:
Managing Major Mental Illness with Dietary Change: The New Science of Hope
Brain Energy: The Metabolic Theory of Mental Illness
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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Is psychiatry stuck in the 19th century? For decades, psychiatry has relied on trial and error but is there a better way to provide precise, personalized, and preventative treatment?
Dr. Alexander Niculescu, professor of psychiatry at the University of Arizona and CEO of MindX Sciences, is at the cutting edge of transforming psychiatry into an objective, data-driven field. With blood tests evaluating specific biomarkers, doctors may now be able to measure mental health, better understand symptoms, and predict which treatments will work best.
In this conversation, Dr. Niculescu explains how his research is helping reshape how we diagnose and treat mental illness allowing for a more personalized approach and potentially better outcomes. He shares research demonstrating how utilizing biomarkers can allow practitioners to better understand the current state of a patient’s mental health to assist in prevention and tailor both medications and lifestyle interventions for better outcomes.
In this episode, you’ll learn:
Why psychiatry is still practiced like 19th-century medicine and how to modernize itHow blood tests can pinpoint the right treatment for a patient including lifestyle interventions, medication choice, and dosingHow blood tests can identify the nuanced difference between mental illnesses like depression and bipolar disorder at a biological levelWhy these tests could be more reliable than genetic testingHow early screening could help prevent serious mental illnessThe future of personalized lifestyle recommendations for mental healthAt Metabolic Mind, we believe mental health care must evolve to incorporate metabolic interventions alongside innovative diagnostic tools. Our vision is a future where the metabolic health of every individual is assessed and addressed with evidence-based interventions, leading to improved mental health for all.
Expert Featured:
Dr. Alexander Niculescu
https://mindxsciences.com/
https://www.linkedin.com/in/alexander-niculescu-md-phd-b460a75/
Studies Mentioned:
Special Report: Precise, Personalized, and Preventive Psychiatry
https://doi.org/10.1176/appi.pn.2024.12.12.27
CMEs Mentioned
Managing Major Mental Illness with Dietary Change: The New Science of Hope
https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616Brain Energy: The Metabolic Theory of Mental Illness
https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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Is it possible for ketogenic therapy to significantly reduce schizoaffective symptoms in 2 weeks? What about putting symptoms into complete remission in 6 weeks?
Licensed Mental Health Counselor Nicole Laurent joins Dr. Bret Scher to discuss her newly published case series showcasing the dramatic improvements in individuals with schizoaffective disorder using ketogenic metabolic therapy.
In this interview, Nicole shares:
The life-changing stories from the patients and their familiesHow she collaborated with healthcare teams to ensure better outcomesHow she determines the right type of ketogenic diet for each patientThe role of nutrient deficiencies and supplementation in treatmentHow medications were handled and her perspective on medication changes with ketogenic therapyThe profound transformations in her patients’ lives, including returning to school and regaining independenceThese stories offer hope and add to the growing evidence that ketogenic therapy can help individuals struggling with mental illness.
Want to hear more real-life experiences of people reclaiming their mental health through metabolic therapy? Hear from our community of experts by experience, including their challenges, setbacks, and successes on the path to recovery at metabolicmind.org/think-smart.
Expert Featured:
Nicole Laurent, LMHC
https://mentalhealthketo.com/
Founder and Medical Director of Mental Health KetoX: @KetoCounselor
LinkedIn: https://www.linkedin.com/in/nlaurent/
Instagram: mentalhealthketo/
Studies Mentioned
Ketogenic metabolic therapy for schizoaffective disorder: a retrospective case series of psychotic symptom remission and mood recovery
https://doi.org/10.3389/fnut.2025.1506304
CMEs Mentioned
Managing Major Mental Illness with Dietary Change: The New Science of Hope
https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616Brain Energy: The Metabolic Theory of Mental Illness
https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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Dr. Iain Campbell, a researcher at the University of Edinburgh, discusses his groundbreaking pilot study on ketogenic therapy for bipolar disorder with Dr. Bret Scher. Having personally experienced the benefits of ketosis for his own bipolar type II depression, Dr. Campbell delves into the link between metabolic health and mental well-being.
Dr. Campbell shares how his recent study reveals a correlation between higher ketone levels and improvements in mood, energy, impulsivity, and anxiety in patients with bipolar disorder. He also highlights the intriguing brain imaging results that indicate reductions in brain glutamate, hinting at one of the potential mechanisms behind ketogenic therapy's effectiveness.
Key Topics Covered:
The correlation between ketone levels and mood stabilizationDr. Campbell’s personal journey using ketogenic therapy for bipolar disorderHow ketosis impacts brain glutamate levelsThe role of metabolic psychiatry in treating mental illnessThe future of metabolic treatments at the newly established UK Metabolic Psychiatry HubDr. Campbell's pioneering work at the Metabolic Psychiatry Hub is advancing the field of metabolic psychiatry by integrating research and treatment, demonstrating how ketogenic therapy can be a powerful tool for addressing both metabolic and mental health in the treatment of bipolar disorder.
New Study:
A Pilot Study of a Ketogenic Diet in Bipolar Disorder: Clinical, Metabolic and Magnetic Resonance Spectroscopy Findings
https://doi.org/10.1192/bjo.2024.841Experts Featured:
Dr. Iain Campbell
X: @IainCampbellPhD
www.metabolicpsychiatryhub.com
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:
Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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Do psychiatric medications alter brain energy and metabolic health?
Dr. Stephen Cunnane, a professor and researcher at the University of Sherbrooke, has been at the forefront of studying glucose and ketone metabolism in the aging brain, pioneering advanced imaging techniques to measure how the brain utilizes these critical energy sources with neurodegenerative conditions like Alzheimer’s and Parkinson’s.
While glucose PET imaging has long been used to study brain energy metabolism, Dr. Cunnane’s team was the first to develop ketone PET imaging, allowing researchers to look at the relationship between glucose and ketone metabolism in the brain and understand how ketones support brain function when it struggles to use glucose for energy.
Now, Dr. Cunnane has turned his attention to metabolic psychiatry and is working on a new study looking at brain energy metabolism in individuals experiencing first-episode psychosis. This study will allow researchers insights into the metabolic state of the brain at the onset of major mental illness and how psychiatric medications influence brain energy use.
In this episode, you will learn:
How the brain uses fuel as we age – Why glucose metabolism declines over time and how ketones may compensate in aging and neurodegenerative conditions.The first ketone PET imaging studies – How Dr. Cunnane’s team developed a method to directly measure ketone uptake in the brain and compare it to glucose metabolismPsychosis and brain energy metabolism – Examining glucose and ketone utilization in first-episode psychosis before and after antipsychotic treatment.Carbohydrate reduction in older adults – Findings from a study showing how moderate carb restriction improved metabolic and mental health in retirement home residents independent of weight loss.Parkinson’s disease and ketones – Investigating how exercise, exogenous ketones, and carbohydrate restriction may enhance brain energy supply and improve symptoms.Dr. Cunnane has been a pioneer in the field of ketogenic therapy and brain energy. In addition to all the incredible work he is doing in the aging brain, we are excited to see his new research focusing on such critical components of metabolic psychiatry.
Expert Featured:
Dr. Stephen Cunnane
https://recherche-cerveau-sherbrooke.ca/en/laboratory-team/
Studies Mentioned
A reduced carbohydrate diet improves glycemic regulation in hyperglycemic older people in a retirement home: the SAGE study
https://doi.org/10.1139/apnm-2024-0277
Resources Mentioned
Brain Research Team Website
https://recherche-cerveau-sherbrooke.ca/en/
Revolutionizing Assisted Living: Hal Cranmer's Ketogenic & Carnivore Approach to Senior Wellness
https://youtu.be/s86CFw0qhVc?feature=shared
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources athttps://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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How can we make sense of conflicting studies? One paper suggests a ketogenic diet reduces all-cause mortality, while another claims it raises blood pressure. Are large-scale survey tools like NHANES—the National Health and Nutrition Examination Survey—really the best way to answer these complex questions?
In this insightful interview, Dr. Adrian Soto-Mota, an internal medicine clinician, educator, and data enthusiast, explains how to critically evaluate research findings. He highlights the strengths and limitations of different types of studies, using engaging analogies to help you better understand when and how to apply research conclusions.
In this video you’ll learn:
The importance of choosing the right tool (study) for the task Strengths and weaknesses of large population studies like NHANES Practical advice for interpreting conflicting health and nutrition researchIf you're passionate about understanding health research and making evidence-based decisions, this interview is a must-watch!
Expert Featured:
Dr. Adrian Soto-Mota
X: @AdrianSotoMota
Studies Mentioned
Ketogenic diets are associated with an elevated risk of hypertension: Insights from a cross-sectional analysis of the NHANES 2007–2018
https://doi.org/10.1016/j.ijcrp.2024.200342
Comparing Very Low-Carbohydrate vs DASH Diets for Overweight or Obese Adults With Hypertension and Prediabetes or Type 2 Diabetes: A Randomized Trial
https://doi.org/10.1370/afm.2968
The ketogenic diet has the potential to decrease all-cause mortality without a concomitant increase in cardiovascular-related mortality
https://doi.org/10.1038/s41598-024-73384-x
CMEs Mentioned
Managing Major Mental Illness with Dietary Change: The New Science of Hope
https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616
Brain Energy: The Metabolic Theory of Mental Illness
https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615
Follow our channel for more insights and education from Dr. Bret Scher, including interviews with leading experts in metabolic psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/.
About us
Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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Pediatric and adolescent mental health challenges, including anxiety, depression, and ADHD, are reaching alarming levels and affecting millions worldwide. While the causes are still being explored, one potential contributing factor is the rising metabolic health epidemic, fueled by a harmful food environment.
With current treatment options often coming with challenging side effects and failing to provide lasting relief, many families are turning to innovative, evidence-based solutions to support their children’s well-being and long-term development.
In this interview, Dr. Lori Calabrese, a board-certified psychiatrist, shares her pioneering work in youth mental health care and discusses her experiences implementing ketogenic therapies in children and young adults.
In this interview, you’ll learn:
What’s the difference between ketogenic therapy for adults vs. children? How to introduce ketogenic therapy to children and young adults The importance of having families on board with ketogenic therapy How to help children and young adults adhere to ketogenic therapiesEveryone deserves access to better mental health care, especially the young minds that hold the future to our society.
Expert Featured:
Dr. Lori Calabrese
X: @loricalabresemd
LoriCalabreseMD.com
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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How Is a ketogenic diet different for women, and what impact does a ketogenic diet have on women’s hormones? The ketogenic diet sparks a lot of questions when it comes to women’s health—and for good reason. Social media and the internet are flooded with conflicting information. Fortunately, Dr. Madison Kackley, a research scientist at Ohio State University, brings evidence-based insights in this episode. As the leader of the SHE IS Laboratory, Dr. Kackley and her team are uncovering the unique ways ketogenic interventions can impact women’s health, considering crucial factors like hormonal fluctuations, menstrual cycles, and key life stages such as postpartum and perimenopause.
In this episode, you’ll learn:
Insights from the SHE IS Lab on ketogenic therapies for PCOS, postpartum depression, perimenopause, and more. How ketogenic therapies are helping restore menstrual cycles and improve hormonal health. The importance of personalized approaches and cycle tracking in women's health research. When ketone supplements may be beneficial for women’s health. How to adjust exercise and nutrition for different stages of the menstrual cycle.Join us as Dr. Kackley shares her passion for addressing the gaps in women-specific health studies and the promising future of metabolic-based interventions for women’s health.
Expert Featured:
Dr. Madison Kackley
X: @KackleyMLPhD
CMEs Mentioned:
Managing Major Mental Illness with Dietary Change: The New Science of Hope
https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616
Brain Energy: The Metabolic Theory of Mental Illness
https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615
Follow our channel for more insights and education from Dr. Bret Scher, including interviews with leading experts in metabolic psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/.
About us:
Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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Mental health care is at a critical crossroads. Millions of people are searching for effective treatments, yet conventional options often fall short, leaving many without significant or lasting relief. Compounding this issue is the lack of funding directed toward exploring novel, root-cause therapies. The urgency for change is clear.
Dr. Chris Palmer, a Harvard psychiatrist and the author of Brain Energy, has been instrumental in raising awareness about the metabolic nature of mental illness. His pioneering work highlights how conditions like depression, bipolar disorder, and schizophrenia often stem from underlying metabolic dysfunctions, including glucose hypometabolism, neurotransmitter imbalances, inflammation, and oxidative stress.
In this interview, Dr. Palmer dives into the science behind mental illnesses and shares groundbreaking insights into how ketogenic therapy is changing lives.
In this interview, you’ll learn:
Why the current mental health system struggles to provide effective care How ketogenic therapies and lifestyle changes are reshaping psychiatry The role of mitochondria and metabolism in brain health The urgent need for research on tapering medications safely The current state of mental health research funding and the path towards systemic change Why mental illness should be viewed as a systemic condition, not just a brain disorderThis conversation highlights the urgent need for change in psychiatry, how metabolic therapies are offering new hope for those living with mental illness, and the path towards more effective evidence based care and better patient outcomes.
Expert Featured:
Dr. Chris Palmer
X: @ChrisPalmerMD
www.ChrisPalmerMD.com
Purchase Brain Energy: https://brainenergy.com/#order-window
Studies Mentioned
Beyond comorbidities: metabolic dysfunction as a root cause of neuropsychiatric disorders
https://www.cambridge.org/core/journals/bjpsych-advances/article/abs/beyond-comorbidities-metabolic-dysfunction-as-a-root-cause-of-neuropsychiatric-disorders/9B7489EF96DCA9F41005DD7E61B27023The Ketogenic Diet as a Transdiagnostic Treatment for Neuropsychiatric Disorders: Mechanisms and Clinical Outcomes
https://link.springer.com/article/10.1007/s40501-024-00339-4CMEs Mentioned
Brain Energy: The Metabolic Theory of Mental Illness
https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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What comes to mind when you think of assisted living? Likely not vibrant residents, nutritious meals, and improved physical and mental health—but Hal Cranmer is working to change that narrative.
In this inspiring interview, Hal shares how his innovative approach to senior care integrates ketogenic and carnivore nutrition to boost activity, memory, and overall well-being in his facilities.
Dive into the secrets of Hal’s success and learn how he’s transforming the lives of seniors by prioritizing health and vitality. If you’re passionate about holistic health or senior wellness, this is a story you won’t want to miss!
Expert Featured:
Hal Cranmer
https://aparadiseforparents.com/
X: @HalCranmer
Instagram: @assisted_living_hal_cranmer
Follow our channel for more insights and education from Dr. Bret Scher, including interviews with leading experts in metabolic psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/.
About us
Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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How effective is exercise for treating depression, and how can we help more people use it as a cornerstone of treatment?
The last decade we have seen mounting evidence that exercise can play a big role in mental health through a variety of mechanisms.
In this interview, Dr. Nick Fabiano, a psychiatry resident and researcher, shares his innovative approach to using exercise as a therapeutic intervention, drawing from his recent co-authored paper.
In this interview you’ll learn:
Why exercise is comparable to antidepressants and therapy in treating mild to moderate depression. How a holistic, lifestyle-based approach can complement traditional treatments. The mechanisms linking exercise to improved mental health, including metabolic health benefits and social interaction. How to personalize exercise prescriptions for individuals based on their physical and mental health needs. Challenges of integrating exercise into psychiatric careMovement is a core pillar of our THINK + SMART program, embodying the 'M' in the acronym. Exercise not only has the remarkable ability to provide an immediate boost to mood and mental clarity but also fosters long-term adaptations that support both metabolic and mental health. As the field of metabolic psychiatry continues to grow, we are optimistic that exercise will become a foundational component in the standard of care for mental health treatment.
Expert Featured:
Nicholas Fabiano, MD
X: @NTFabiano
Studies Mentioned:
How to Prescribe Physical Activity for Depression
*https://doi.org/10.1024/2674-0052/a000099**Importance of Frequency, Intensity, Time and Type (FITT) in Physical Activity Assessment for Epidemiological Research
https://doi.org/10.1007/BF03404889
The Effect of Exercise on Suicidal Ideation and Behaviors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
https://doi.org/10.1016/j.jad.2023.02.071
CMEs Mentioned
Managing Major Mental Illness with Dietary Change: The New Science of Hope
https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616
Brain Energy: The Metabolic Theory of Mental Illness
https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615
Follow our channel for more insights and education from Dr. Bret Scher, including interviews with leading experts in metabolic psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/.
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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The Dietary Guidelines for Americans (DGA) have the potential to shape the health of millions, but are they based on outdated or flawed evidence? In this powerful interview, Dr. Bret Scher and investigative journalist Nina Teicholz expose the controversial history of dietary policy, challenge the methodology of the DGA Advisory Committee, and discuss the urgent need for change to address rising rates of metabolic and mental health disorders. And they try to answer the burning question from the guidelines: Will eating more beans, peas, and lentils make all of us healthier?
What you will learn in this interview:
What is the importance of the Dietary Guidelines for Americans? How is the Dietary Guidelines Advisory Committee committee selected? How is the DGA created and what is the quality of evidence? What are the conflicts of interest in current and past DGA committees? How are decades-old biases shaping current dietary policies? How is the DGA failing to consider individual needs? What do we know about the upcoming 2025 DGA? What are we hoping for in the upcoming 2025 Dietary Guidelines?This timely discussion brings both hope and urgency as they address the question: Will the next guidelines reflect the latest research or continue to steer us in the wrong direction?
Expert Featured:
Nina Teicholz
X: @bigfatsurprise
IG: @ninateicholz
Substack: https://unsettledscience.substack.com/
Publications Mentioned
Scientific Report of the 2025 Dietary Guidelines Advisory Committee
https://www.dietaryguidelines.gov/2025-advisory-committee-reportRedesigning the Process for Establishing the Dietary Guidelines for Americans.
https://www.ncbi.nlm.nih.gov/books/NBK469833/Report: Nearly Half of Dietary Guidelines Advisory Committee Have Conflicts of Interest
https://usrtk.org/investigations/dietary-guidelines-advisory-committee-conflicts/Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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Learn how Continuous Glucose Monitors (CGMs) can transform your metabolic and mental health. In this video, we dive into the benefits and debates surrounding CGMs, highlighting their role in managing blood sugar, making informed lifestyle choices, and enhancing overall well-being.*Key Topics Covered*• What are Continuous Glucose Monitors (CGMs)?• How CGMs can help improve metabolic health• Important considerations and potential drawbacks of using CGMs• Tips for getting the most out of your CGM experienceWhether you're new to CGMs or already using them, this is your guide to understanding their impact on your health journey.Resources:Metabolic Mind’s Families & Peers page:https://www.metabolicmind.org/families-and-peersClinician Directory:https://www.diagnosisdiet.com/directoryFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.#MetabolicMind #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis#AlternativeTreatment#MedicalKeto#KetogenicTherapy #MetabolicHealth#Insulin#CGM
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Dr. Bret Scher interviews Dr. Jack Gilbert—renowned microbiome scientist, author of Dirt Is Good, and featured expert in the Netflix documentary Hack Your Health—to explore the profound connections between the microbiome, metabolism, mental health, and overall wellness.
Dr. Gilbert shares cutting-edge insights into how the 40 trillion microbes in our gut influence everything from inflammation to brain health, and how personalized strategies may hold the key to treating chronic illnesses and improving quality of life.
What You'll LearnThe role of the microbiome in metabolic and mental healthHow diet and lifestyle shape your gut bacteriaSurprising links between exercise, mitochondria, and the microbiomeEmerging research on fecal transplants and their transformative potentialWhy personalized nutrition might be the future of healthcare
Experts FeaturedDr. Jack GilbertX: @gilbertjackaLinkedIn: https://www.linkedin.com/in/drjackagilbert/Gilbert Lab: https://gilbertlab.ucsd.edu/Dirt is Good: https://www.amazon.com/Dirt-Good-Advantage-Childs-Developing/dp/1250132606Hack Your Health: https://www.netflix.com/title/81436688
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/
About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. -
Dr. Bret Scher interviews Dr. Josef Witt-Doerring, a board-certified psychiatrist who specializes in tapering and deprescribing psychiatric medications. Dr. Josef combines his expertise in pharmaceutical safety, clinical psychiatry, and metabolic therapies to help patients safely transition off long-term medications.Topics CoveredLife-Changing OutcomesDiscover how Dr. Josef’s holistic methods have empowered individuals like Trudy, who transitioned from years of debilitating medications to pursuing a career in medical school through targeted dietary and metabolic interventions.Rethinking Psychiatric MedicationsDr. Josef discusses the complex nature of antidepressants, antipsychotics, and mood stabilizers. Learn how their effects can mask symptoms without addressing root causes and the challenges of long-term use, including tolerance, side effects, and withdrawal.The Role of Metabolic TherapiesHear about the surprising success stories of patients who used dietary changes like ketogenic or gluten-free diets to overcome severe mental health conditions, reduce medication reliance, and regain their quality of life.Deprescribing in PracticeDr. Josef shares his patient-led approach to tapering medications, including practical tips on dosage reduction, liquid formulations, and the importance of balancing withdrawal risks with ongoing medication effects.Dr. Josef’s message challenges conventional psychiatry by prioritizing patient-centered care and exploring innovative therapies that focus on the root causes of mental health challenges. This conversation provides hope and practical insights for individuals and clinicians navigating the complexities of psychiatric medication.Experts FeaturedDr. Josef Witt-Doerring Taper Clinichttps://taperclinic.com/dr-josef-witt-doerring/X: @taperclinicInstagram: https://www.instagram.com/taperclinic/Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.#MetabolicMind #MetabolicNeuroscience #MetabolicPsychiatry#KetogenicMetabolicTherapy #KetogenicTherapy#KetoForMentalHealth#Keto#TaperingMedications #Deprescribing
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In this interview with Dr. Bret Scher, Dr. Corinde Wiers, Assistant Professor of Psychiatry at the University of Pennsylvania, unveils her groundbreaking research on using ketogenic therapy to treat alcohol use disorder (AUD). Dr. Wiers dives into how ketones, as an alternative energy source, may alleviate withdrawal symptoms, reduce cravings, and transform the landscape of addiction recovery.This conversation covers:The science of brain energy metabolism and how ketones are preferred over glucose in AUD.Results from clinical trials, including reductions in withdrawal severity and the need for benzodiazepines.Neuroimaging data that shows how ketogenic diets affect the brain's reward system and craving mechanisms.The broader implications of metabolic therapies for treating mood disorders, addiction, and brain health.Dr. Wiers shares her journey from studying alcohol use disorders in Europe to leading cutting-edge research in the U.S. She provides insights into the challenges and opportunities of integrating metabolic therapies into mainstream mental health and addiction treatment.Experts FeaturedDr. Corinde WiersX: @CorindeWLinkedIn: https://www.linkedin.com/in/corinde-wiers-479a9219/https://www.med.upenn.edu/csa/corindewiers.htmlResources: Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodentshttps://pubmed.ncbi.nlm.nih.gov/33837086/Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.#MetabolicMind #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis
#AlternativeTreatment
#PsychiatricMedication#KetogenicTherapy #KetoforAlcoholUseDisorder
#AlcoholUseDisorder
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Join us as we delve into the transformative potential of metabolic psychiatry with Dr. Scott Fears, MD, PhD, Chief Medical Officer at Amae Health. In this comprehensive interview, Dr. Fears explores how ketogenic therapy, dietary adjustments, and personalized metabolic approaches are reshaping mental health treatment. He discusses ketosis as a therapeutic tool, its impact on mood and cognitive stability, deprescribing medications, and the potential of "food as medicine" to support mental well-being.Whether you're a mental health professional, someone exploring alternative mental health treatments, or simply interested in the intersection of nutrition and mental health, this interview offers valuable insights into metabolic psychiatry's potential to create a new standard for mental health care.Experts FeaturedScott Fears, MD, PhDChief Medical Officer, Amae Healthhttps://www.linkedin.com/in/scott-c-fears-99b8b14/https://amaehealth.com/Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.#MetabolicMind #MetabolicNeuroscience #KetogenicMetabolicTherapy #KetogenicTherapy#KetoForMentalHealth #Alzheimers#Dementia#Keto
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