Afleveringen
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Purespring Therapeutics is a precision nephrology company pioneering first-in-class, targeted genetic therapies designed to preserve kidney function.
In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Haseeb Ahmad, CEO of Purespring, who discusses transforming the treatment of kidney disease, an area of enormous unmet need, with more than 840 million people worldwide living with chronic kidney disease.
Indeed, Purespring’s lead programme is the podocyte-targeted gene therapy PS-002, which is for IgA nephropathy (or IgAN). The conversation also touches upon the evolution of the gene therapy landscape more generally, and where next with this type of innovation in the nephrology space.
You can listen to episode 267 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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Europe's biotech sector is facing an innovation cliff, with fewer clinical starts, tighter capital, and increasing development complexity.
In a new pharmaphorum podcast, web editor Nicole Raleigh caught up with Paul Bridges, president, consulting, at Parexel, and Charlotte Moser, Parexel’s chief medical officer, following BIO-Europe Spring in Lisbon, Portugal.
The conversation touches upon regulatory strategy and evolving policy shifts, trial design and execution – and the importance of patient centricity – as well as AI in drug development and medical leadership in drug development today.
You can listen to episode 266 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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Zijn er afleveringen die ontbreken?
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Cutaneous T-cell lymphoma (or CTCL) is a rare form of non-Hodgkin lymphoma that begins in T lymphocytes, a kind of white blood cell that plays a crucial role in the immune system. And Citius Oncology is focused on developing and commercialising a targeted immune therapy for the initial indication of the treatment of persistent or recurrent CTCL.
In a new pharmaphorum podcast, web editor Nicole Raleigh spoke with Leonard Mazur, CEO and Chairman of Citius Pharmaceuticals about the launch of its first FDA-approved drug, Lymphir, for CTCL.
Mazur discusses the landscape of unmet need in this space, as well as Citius’ advancement of clinical trials in other areas without approved treatments and the future horizon for such oncological innovations.
You can listen to episode 265 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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The radiopharmaceutical sector is in the midst of a transformative year in 2026, with significant developments and challenges, including policy and reimbursement, increasing demand and growth within precision oncology and molecular imaging, and the need for specialised CDMOs when it comes to the intricate nature of radiopharmaceutical manufacturing.
In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Dr Andrew Cavey, CEO of ITM, about current and future radiopharmaceutical trends.
Dr Cavey discusses the evolution of radiopharma, beyond the original “two pillars” of GEP-NETs and PSMA, including the move towards a multi-isotope model, as well as ITM’s pipeline and the potential growth of the broader radiopharma ecosystem going forward.
You can listen to episode 263 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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2026 is the year of a major wave of pharmaceutical patent expirations, with numerous blockbuster drugs – spanning diabetes, immunology, cardiovascular, oncology, and other therapeutic areas – on the verge of losing market exclusivity.
In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Rebecca Guntern, chief commercial officer at Sandoz, for a conversation on the ‘golden decade’ for generics and biosimilars as so many blockbuster drugs come off patent.
Guntern discusses why the current wave of blockbuster biologics losing exclusivity is so significant for patient access and healthcare budgets, and the conversation also touches upon policy and regulatory changes still needed in order to unlock the full potential of biosimilars, as well as what should be expected from the next generation of biosimilars.
You can listen to episode 263 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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In a new pharmaphorum podcast, web editor Nicole Raleigh spoke with Lee-Ann Farrell, Head of National Programmes at Johnson & Johnson, about what delivery will look like in practice when it comes to the National Cancer Plan, the 10-Year Health Plan, and the Life Sciences Sector Plan.
The conversation ranges what comes next following the clear policy direction of the Plans, including how the system can move from ambition to implementation, particularly in ensuring innovation is adopted consistently and at pace across cancer care.
Farrell discusses the role of innovative medicines within evolving care pathways – as ambitions grow around earlier diagnosis, improved outcomes, and care closer to home – as well the dual role of innovative medicines, both as drivers of better patient outcomes and as contributors to economic growth and system sustainability.
You can listen to episode 262 to go here of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Kris Kaneta, chief product officer at Norstella, which is helping life sciences companies speed up development with instant strategy recommendations.
Kaneta discusses AI in drug trials and commercialisation and just what’s possible when clinical AI has access to a data set robust enough to allow it to make real strategic recommendations.
Kaneta also touches upon why patient-level data is pharma's most important asset in the AI race and the roadblocks that stand in the way of further expanding the efficacy of AI for clinical trials.
You can listen to episode 261 to go here of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Dr Ramy Younes, Corporate Vice President, Global Head of Clinical Development, CardioRenalMetabolism, at Boehringer Ingelheim.
The conversation explores the crisis beyond obesity that many clinicians and health systems are now grappling with: that obesity can’t be treated as a short-term, weight-loss lifestyle issue. Rather, it needs to be managed as a complex, chronic, multi-organ disease.
Younes discusses how liver disease is often missed in cardiometabolic risk and is referred to as the ‘liver blind spot’, as well as what integrated pathways can do to improve outcomes and ease system pressure.
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In a new pharmaphorum podcast, web editor Nicole Raleigh sat down with Dr Cedrik Britten, chief medical officer at Immatics, to discuss novel PRAME-directed T-cell immunotherapies.
Targeting PRAME unlocks new treatment options for a broad patient population with significant unmet medical need. And to do so safely and effectively requires deep expertise in immunology, drug development, and beyond.
Britten explains how finding the right cancer target is only half the equation – the other half is creating the key that fits the lock to that cancer. So it is that, in addition to discovery of tumour-specific targets like PRAME, Immatics designs either engineered T-cell receptors (or TCRs) or bispecific molecules that recognise and bind to those targets.
Britten also shares his dreams for the future of the field; his hopes far into the distant horizon.
You can listen to episode 259 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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Longevity and healthspan have emerged rapidly as an increasingly serious category of healthcare study and investment. But there are a lot of ideas inside the industry and out about exactly what the goal is. Is it about extending lifespans as much as possible? Are we trying to live forever? Or do we just want to experience less physical and cognitive decline as we age?
In today’s episode of the pharmaphorum podcast, host Jonah Comstock speaks with Boyang Wang, the founder of Immortal Dragons, a $40 million Singapore-based fund focusing exclusively on moonshot longevity innovations.
In a broad-ranging conversation, they talk about popular misconceptions about the longevity space and why it’s something that everyone should care about. They talk a bit about specific areas of investment for Immortal Dragons like organ synthesis and gene therapy. And they try to look ahead into the future of a space which is all about getting us to that future alive and well.
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Today, the life sciences sector is prioritising recruitment of leaders who can scale efficiently in capital-constrained environments, as well as focusing on hybrid operator-strategists who can integrate AI into R&D, clinical, and commercial workflows.
In a new pharmaphorum podcast, web editor Nicole Raleigh spoke with John Holodnak, co-founder of Occam, about how AI is beginning to reshape career paths across life sciences.
Holodnak discusses AI’s transformation of functional roles in life sciences, such as regulatory, market access, and business development, and explores the breakdown of linear career paths and way ahead for biotech and pharma professionals tomorrow.
You can listen to episode 257 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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Pharma and tech companies are working more closely together than ever. As proven by the news of Merck and NVidia’s new partnership, for example. But while the idea of using AI for drug discovery has been around for a while now, patient access has an awfully long way to catch up to the promise of these new therapies.
In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Dean Erhardt, founder of D2 Solutions, an end-to-end strategic partner delivering industry-leading consulting and purpose-built technologies to pharma manufacturers, hospitals, pharmacies, payers & PBMs.
The conversation focuses on the disconnect between distributions, reimbursements, and patient services, particularly when it comes to speciality medicines, as well as patient access today versus the state of patient access tomorrow, and the benefit or otherwise of price protection guarantees with PBMs, when it comes to new therapies.
You can listen to episode 256 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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Despite billions spent on new technology and improving data analytics, companies continue to struggle with commercial launch success, with around 35% of launches missing expectations since 2012.
Why is launch underperformance such a big problem, and why isn’t technology alone offering a sufficient solution? In a special episode of the pharmaphorum podcast, sponsored by Axtria, we spoke with Amanjeet Singh Saluja, a Principal at Axtria, about the current state of affairs in launch success.
In our conversation, Singh Saluja digs into the strategic and institutional causes of failed launches and what strategies can help redeem them. He also discusses some of the external forces that have reshaped the pharma commercialisation industry, and how to keep pace with those trends and changes.
Finally, of course, we talk about agentic AI. Even though it may not be a silver bullet, when used correctly, in the right strategic context, it can make a big difference.
Meet Singh Saluja and other senior life sciences commercialisation leaders at Axtria Ignite 2026, an invitation-only event where the industry works through these challenges and more. June 10-11th in Princeton, NJ. Register here.
About the IntervieweeAmanjeet Singh Saluja is a seasoned leader in AI, analytics, and cloud software. He currently heads a Strategic Business Unit at Axtria Inc., a leading global provider of AI and cloud solutions to the life sciences industry. Singh Saluja has built, scaled, and exited three successful ventures, and is the original inventor of a US patent for collection cycle optimisation through advanced analytics. He brings 26 years of experience advising Fortune 500 clients in financial services, life sciences, and MedTech on risk management, commercial strategies, and artificial intelligence. He has been recognised in Marquis Who’s Who in 2025.
Singh Saluja is particularly skilled at driving growth, improving sales efficiency, optimising costs, cultivating high-performing teams, and fostering a culture of collaboration and excellence through executive leadership. He began his career in process re-engineering and strategy roles at KPMG and Andersen. Singh Saluja holds a degree from the Indian Institute of Technology Kharagpur and an MBA from the Indian Institute of Management, Ahmedabad. He is passionate about leveraging AI and analytics to drive business success.
About AxtriaAxtria helps life sciences companies harness the potential of data science and software to improve patient outcomes by connecting the right therapies to the right patients at the right time. The company is a leading global provider of award-winning cloud software and data analytics to the life sciences industry. We’re proud to deliver proven solutions that help pharmaceutical, medical device, and diagnostics companies complete their journey from data to insights to action, enabling them to earn superior returns on their investments. As a participant in the United Nations Global Compact, Axtria is committed to aligning strategies and operations with universal principles on human rights, labor, environment, and anti-corruption, and taking actions that advance societal goals. For more information, please visit www.axtria.com.
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Here at pharmaphorum we tend to focus on the latest developments in the pharmaceutical space. And to be fair, that’s quite a lot to keep us busy. But the history of pharma is full of incredible stories that might just be new to a lot of people, even those inside the industry.
On today’s episode of the pharmaphorum podcast, host Jonah Comstock speaks with Thomas Goetz, former executive editor of Wired; co-founder of Iodine, a drug data company that was acquired by GoodRx; and, most recently, creator and host of the Drug Story podcast.
Each episode of Drug Story dives into the story behind a particular drug and the condition that it treats, unlocking fascinating morsels of history and, indeed, current controversies along the way.
Goetz discusses the inspiration for the show and what he hopes listeners will take away from it. He also talks about how his perspective is neither pro- nor anti-pharma, but about recognising pharmaceutical medicine as the socially and morally complex market that it is.
Take a listen for a taste of how every drug contains a multitude of stories, and then check out season 1 of Drug Story if you want a little more.
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In a new episode of the pharmaphorum podcast, web editor Nicole Raleigh spoke with Lance Baldo, CEO of Beacon Therapeutics, a clinical-stage biotechnology company harnessing the transformative power of gene therapy to deliver meaningful outcomes for severe ocular diseases.
Baldo discusses the ocular disease landscape, as well as Beacon’s work targeting X-linked retinitis pigmentosa (XLRP) and geographic atrophy (GA), and what the future could look like in terms of innovation in this field.
You can listen to episode 253 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it – and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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In a new episode of the pharmaphorum podcast, recorded at BIO-Europe Spring in Lisbon, Portugal, web editor Nicole Raleigh spoke with Kashif Sadiq, founder and CEO of DenovAI Biotech, a company that believes humanity is on the cusp of a protein design revolution that stands to transform both human health and the world around us.
Sadiq discusses the company's springboard from AION Labs - with a first-of-its-kind alliance of AstraZeneca, Merck, Pfizer, Teva, the Israel Biotech Fund, Amiti Ventures, and Amazon Web Services, powered by BioMed X with the support of the Israeli Government.
He also explores harnessing the power of artificial intelligence and computational molecular biophysics, developing foundational technology platforms that can design proteins de novo, and describes the trends and insights from the conference itself this year.
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At BIO-Europe Spring 2026 in Lisbon, Portugal, web editor Nicole Raleigh spoke with Dr Olga Nissan, vice president of business development at Evogene, a computational chemistry company, specialising in the generative design of small molecules for the pharmaceutical and agricultural industries.
Nissan discusses recent developments at Evogene, including its extended collaboration with Google Cloud to develop and integrate AI agents into Evogene’s ChemPass AI platform, as well as its collaboration with Queensland University of Technology in the non-small cell lung cancer (NSCLC) space. She also speaks to where industry is at in its integration of cutting-edge AI into scientific research.
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In a new pharmaphorum podcast, web editor Nicole Raleigh was joined by Rob DiCicco, vice president of portfolio management at Transcelerate Biopharma Inc, for a conversation on the barriers and the breakthroughs in making AI work in drug development and clinical trials.
DiCicco discusses why AI adoption in clinical trials is so different from preclinical research and development, as well as how synthetic control arms and in silico modelling reshape trial design, and he touches upon the need for making AI solutions meet not just regulatory and scientific standards, but ethical standards, also.
You can listen to episode 250 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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Genetic diseases are notoriously challenging to treat, especially when each condition requires a tailored approach. With over 10,000 known genetic disorders, developing individual therapies for each one has been an immense hurdle, particularly for rare diseases affecting small patient populations. But what if there was a way to address multiple conditions simultaneously, using a single, universal approach?
In today’s episode of the pharmaphorum podcast, Michelle Werner, CEO of Alltrna, discusses her company’s approach of leveraging transfer RNA (tRNA) to shift the paradigm in genetic medicine. This approach has the potential to offer hope to millions of patients with rare and ultra-rare diseases, bypassing traditional one-disease-at-a-time models.
Werner discusses how engineered tRNA works, how this technology slots into existing regulatory frameworks, and why this could be a game changer for pharmaceutical development.
You can listen to episode 249 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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In a new episode of the pharmaphorum podcast, web editor Nicole Raleigh speaks with Andrew Mackinnon, senior vice president and executive general manager at Medable, about leveraging AI to transform clinical development and accelerate lifesaving therapies to patients.
Mackinnon discusses ‘white space’ in R&D, about integrating generative and agentic AI with human-in-the-loop oversight while prioritising patient safety and regulatory, and how all this advances health equity for underserved communities.
You can listen to episode 248 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.
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