Afleveringen
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Does intelligent life exist elsewhere in the universe? The question has captivated us for centuries, but despite decades of searching it remains frustratingly unanswered. Every so often a curious signal appears — fossilized structures in a meteorite, say, or an unusual gas in an exoplanet’s atmosphere — and for a moment it seems possible that we are not alone before the excitement gives way to a more mundane explanation.
So what would it actually take to find life in the cosmos — and how would we know when we saw it?
David Kipping, an astronomer at Columbia University, has spent his career finding better ways to answer these questions. His approach is statistical: rather than chasing individual detections, he develops mathematical frameworks for reasoning about where habitable worlds are likely to exist and how confidently we can interpret the signals they produce. In this episode of The Joy of Why, Kipping joins co-host Janna Levin to discuss efforts to frame one of humanity’s oldest existential questions as a tractable scientific problem, why biosignatures have proved so difficult to interpret, and why he believes exomoons may be an overlooked place to search for life.
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What links certain mathematical models of traffic flow, shallow-water waves, and quantum particle scattering? The surprising answer lies in a corner of the algebraic combinatorics world that goes by the name of positive Grassmannian. In simple terms, the positive Grassmannian is a shape that classifies other shapes. Remarkably, pieces of the positive Grassmannian can be reassembled in forms that reveal shared structures in these and many other seemingly unrelated mathematical systems.
That we know the positive Grassmannian crops up in many real-world settings is largely down to the theoretical work of Lauren Williams at Harvard University. In this latest episode of The Joy of Why, Williams talks to co-host Steven Strogatz about her work, how she realized the surprising pervasiveness of the positive Grassmannian, and how she has made a career of finding connections among fields that don’t at first sight seem connected. The conversation then switches to another project Williams is working on, called First Proof, which is trying to measure objectively how good AI systems are at coming up with proofs of research-level mathematical statements, and which leads to an exploration of whether AI may or may not take over mathematics.
Note: Since this conversation was recorded, results from the First Proof, Second Batch project were released on June 10 2026.
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One of the most surprising and remarkable discoveries in recent scientific history has been CRISPR. Short for Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR is a form of immune system that evolved in bacteria more than a billion years ago to defend against persistent viral threats. Under attack, bacteria can snip a small fragment of a virus’s DNA, store it in the CRISPR region of their genome, and then use it to recognize and destroy the same virus if it returns. The CRISPR-Cas9 system, to give it its longer name, consists of a short strand of guide RNA that identifies where to cut the DNA and a protein that acts as the molecular scissors.
What made this system truly revolutionary was the demonstration in 2012 that it could be reprogrammed with different pieces of guide RNA to edit virtually any genome in any species, and at a level of precision and ease that far surpassed existing gene-editing tools. Since then, the editing capability of CRISPR has been tested on everything from developing disease treatments to engineering drought-resistant crops to resurrecting genes of extinct species. The possibilities have expanded so rapidly that researchers, ethicists, and regulators have found themselves struggling to keep up.
One person acutely aware of the power of CRISPR is Jennifer Doudna, co-developer of the technology. Doudna, who received the Nobel Prize in Chemistry in 2020 with Emmanuelle Charpentier for this pioneering work, has been a prominent voice not only for its vast potential but also for its responsible and ethical use. In this episode of The Joy of Why, Doudna tells co-host Janna Levin how her early, “rebellious,” decision to study RNA led her on a serendipitous path to one of biology’s most transformative discoveries. They also discuss the breakthroughs, barriers, and frontiers that will define CRISPR’s true impact.
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What is the future of gene editing with CRISPR? Has AI changed mathematics forever? Will we find other civilizations in the universe? What if we’ve been wrong about dark energy all along? These are just a few of the big, bold questions we’ll be exploring in the new season of The Joy of Why.
Mathematician Steven Strogatz and physicist Janna Levin are back as your hosts for these and other conversations that explore the frontiers of basic science and mathematics. Each episode features an in-depth conversation in which Steven or Janna sits down with a leading scientist or mathematician to unpack one big idea or area of research. The two hosts also chat together throughout each episode, sharing their own thoughts, reactions, and questions.
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Birds are not merely descendants of dinosaurs — they are dinosaurs. For Yale evolutionary biologist and ornithologist Richard Prum, birds have been a lifelong passion and a window into some of evolution’s most intriguing mysteries.
In a wide-ranging conversation with co-host Janna Levin, Prum traces the deep evolutionary origins of feathers, which he argues first emerged not for flight but for insulation, camouflage and display. Their colors — often invisible to the human eye — come into sharp focus under birds’ ultraviolet vision, suggesting a sensory world far richer than our own.
Prum also explains why he champions Darwin’s once-marginalized theory of sexual selection, which proposes that traits such as the peacock’s tail evolved not for survival, but simply because they were attractive. Beauty, in other words, may shape life as powerfully as utility.
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Every time data travels — from smartphones to the cloud, or across the vacuum of space — it relies on a silent but vigilant guardian in the form of error-correcting codes. These codes, baked into nearly every digital system, are designed to detect and repair any errors that noise, interference or cosmic rays might inflict.
In this episode of The Joy of Why, Stanford computer scientist Mary Wootters joins co-host Steven Strogatz to explain how these codes work, and why they matter more than ever. Wootters discusses the evolving list of codes that keep modern communication resilient, and the frontiers in which error correction may have a crucial role, including distributed cloud systems, quantum computing and even DNA-based data storage.
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Most cosmologists agree that our universe had a beginning. But the finer details about the Big Bang remain a mystery. A history of everything would explain all, or so theoretical physicists hoped. In his final years, Stephen Hawking working with Thomas Hertog proposed a striking idea: The laws of physics were not precisely determined before the Big Bang; they evolved as the universe evolved.
In this episode of The Joy of Why, Hertog speaks with co-host Janna Levin about his work and partnership with Hawking. Hertog, now at KU Leuven in Belgium, explains why they rejected the popular multiverse theory and instead explored the idea that the universe’s properties are a result of cosmological natural selection. According to Hertog and Hawking, these properties must be viewed through the lens of human observers, who are also the consequence of natural selection.
So, how could the universe have created the conditions needed for life to emerge? Listen to the episode below to find out.
Listen on Apple Podcasts, Spotify, TuneIn or your favorite podcasting app, or you can stream it from Quanta.
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Climate models have changed the way we view the world. While effective, these models are imperfect, and scientists are constantly looking at ways to improve their accuracy and predictability.
MIT professor Elfatih Eltahir has spent decades developing complex models to understand how climate change affects vulnerable regions like the Nile Basin and Singapore. In this episode of The Joy of Why, Eltahir tells co-host Steven Strogatz how growing up near the Nile in Sudan helped him realize that climate change doesn’t occur in isolation. To better understand climate-related impacts and to create more effective adaptation strategies, Eltahir says we need regional models that incorporate contextual data like disease spread and population growth. Eltahir also discusses his “Equation of the Future of Africa,” and he introduces the concept of “outdoor days,” which he hopes can improve public perception about climate change.
Listen on Apple Podcasts, Spotify, TuneIn or your favorite podcasting app, or you can stream it from Quanta.
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Born in the 18th century when Leonhard Euler solved the puzzle of the seven bridges of Königsberg, graph theory has become a foundational tool in mathematics. It studies relationships through nodes (vertices) and the links (edges) that connect them, transforming the complexity of systems — from friendship networks to airline routes — into elegant abstractions that reveal underlying structure and interaction.
Maria Chudnovsky from Princeton University is a leading mathematician in the field. In this episode of The Joy of Why, Chudnovsky talks with co-host Janna Levin about how she got into graph theory, solved the decades-old perfect graph problem, and used it to plan her wedding seating chart. Chudnovsky also reflects on her appearance in commercials as a “superstar mathematician,” and how her background primed her for a discipline that transcends language, culture and time.
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What links a Möbius strip, brain folds and termite mounds? The answer is Harvard University’s L. Mahadevan, whose career has been devoted to using mathematics and physics to explore the form and function of common phenomena.
Mahadevan, or Maha to his friends and colleagues, has long been fascinated by questions one wouldn’t normally ask — from the equilibrium shape of inert objects like a Möbius strip, to the complex factors that drive biological systems like morphogenesis or social insect colonies.
In this episode of The Joy of Why, Mahadevan tells co-host Steven Strogatz what inspires him to tackle these questions, and how gels, gypsum and LED lights can help uncover form and function in biological systems. He also offers some provocative thoughts about how noisy random processes might underlie our intuitions about geometry.
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For decades, string theory has been hailed as the leading candidate for the theory of everything in our universe. Yet despite its mathematical elegance, the theory still lacks empirical evidence.
One of its most intriguing, yet vexing, implications is that if all matter and forces are composed of vibrations of tiny strands of energy, then this allows for a vast landscape of possible universes with different physical properties, varieties of particles and complex spacetimes. How, then, can we possibly pinpoint our own universe within a field of almost infinite possibilities?
Since 2005, Cumrun Vafa(opens a new tab) at MIT has been working to weed out this crowded landscape by identifying which hypothetical universes lie in a ‘swampland’ with properties inconsistent with the world we observe. In this episode of The Joy of Why, Vafa talks to co-host Janna Levin about the current state of string theory, why there are no more than 11 dimensions, how his swampland concept got an unexpected lift from the BICEP array, and how close we may be to testable predictions.
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Geometry is one of the oldest disciplines in human history, yet the worlds it can describe extend far beyond its original use. What began thousands of years ago as a way to measure land and build pyramids was given rigor by Euclid in ancient Greece, became applied to curves and surfaces in the 19th century, and eventually helped Einstein understand the universe.
Yang-Hui He sees geometry as a unifying language for modern physics, a mutual exchange in which each discipline can influence and shape the other. In the latest episode of The Joy of Why, He tells co-host Steven Strogatz how geometry evolved from its practical roots in ancient civilizations to its influence in the theory of general relativity and string theory — and speculates how AI could further revolutionize the field. They also discuss the tension between formal, rigorous mathematics and intuition-driven insight, and why there are two types of mathematicians — “birds” who have a broad overview of ideas from above, and “hedgehogs” who dig deep on one particular idea.
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Large language models (LLMs) are becoming increasingly more impressive at creating human-like text and answering questions, but whether they can understand the meaning of the words they generate is a hotly debated issue. A big challenge is that LLMs are black boxes; they can make predictions and decisions on the order of words, but they cannot communicate the reasons for doing so.
Ellie Pavlick at Brown University is building models that could help understand how LLMs process language compared with humans. In this episode of The Joy of Why, Pavlick discusses what we know and don’t know about LLM language processing, how their processes differ from humans, and how understanding LLMs better could also help us better appreciate our own capacity for knowledge and creativity.
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Quantum gravity is one of the biggest unresolved and challenging problems in physics, as it seeks to reconcile quantum mechanics, which governs the microscopic world, and general relativity, which describes the macroscopic world of gravity and space-time.
Efforts to understand quantum gravity have been focused almost entirely at the theoretical level, but Monika Schleier-Smith at Stanford University has been exploring a novel experimental approach — trying to create quantum gravity from scratch. Using laser-cooled clouds of atoms, she is testing the idea that gravity might be an emergent phenomenon arising from quantum entanglement.
In this episode of the Joy of Why podcast, Schleier-Smith discusses the thinking behind what she admits is a high-risk, high-reward approach, and how her experiments could provide important insights about entanglement and quantum mechanical systems even if the end goal of simulating quantum gravity is never achieved.
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Quantum computing promises unprecedented speed, but in practice, it’s proven remarkably difficult to find important questions that quantum machines can solve faster than classical ones. One of the most notable demonstrations of this came from Ewin Tang, who rose to prominence in the field as a teenager. When quantum algorithms had in principle cracked the so-called recommendation problem, Tang designed classical algorithms that could match them.
So began the approach of “dequantizing,” in which computer scientists look at quantum algorithms and try to achieve the same speeds with classical counterparts. To understand the ongoing contest between classical and quantum computing, co-host Janna Levin spoke to Tang on The Joy of Why podcast. The wide-ranging conversation covered what it was like for Tang to challenge the prevailing wisdom at such a young age, the role of failure in scientific progress, and whether quantum computing will ultimately fulfill its grand ambitions.
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At first, life on Earth was simple. Cells existed, functioned and reproduced as free-living individuals. But then, something remarkable happened. Some cells joined forces, working together instead of being alone. This transition, known as multicellularity, was a pivotal event in the history of life on Earth. Multicellularity enabled greater biological complexity, which sparked an extraordinary diversity of organisms and structures.
How life evolved from unicellular to multicellular organisms remains a mystery, though evidence indicates that this may have occurred multiple times independently. To understand what could have happened, Will Ratcliff at Georgia Tech has been conducting long-term evolution experiments on yeast in which multicellularity develops and emerges spontaneously.
In this episode of The Joy of Why podcast, Ratcliff discusses what his “snowflake yeast” model could reveal about the origins of multicellularity, the surprising discoveries his team has made, and how he responds to skeptics who question his approach.
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How did complex life evolve? Where did space-time come from? Will computers ever understand language like we do? How did geometry create modern physics? These are just a few of the big and bold questions that we’ll be exploring in the latest season of Quanta’s interview podcast, “The Joy of Why,” starting March 20, and released every other Thursday.
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We have identified thousands of planets just in our neighborhood in the Milky Way, mostly from the way they impact their host stars. Basic calculations suggest that there are countless more across the galaxy, and that billions of them could potentially support life. But what kind of life they host, and how we would be able to detect the presence of those biological processes from Earth, remain big questions in the world of exoplanets and astrobiology. What technologies might lie ahead to help us answer the question of whether we are alone in the universe? Lisa Kaltenegger, an astrophysicist and astrobiologist at Cornell University, talks to Janna Levin about that search, the atmospheric fingerprints of life, and why an advanced alien civilization might decide not to talk to us.
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Death might seem like a pure loss, the disappearance of what makes a living thing distinct from everything else on our planet. But zoom in closer, to the cellular level, and it takes on a different, more nuanced meaning. There is a challenge in simply defining what makes an individual cell alive or dead. Scientists today are working to understand the various ways and reasons that cells disappear, and what these processes mean to biological systems. In this episode, cellular biologist Shai Shaham talks to Steven Strogatz about the different forms of cell death, their roles in evolution and disease, and why the right kinds and patterns of cell death are essential to our development and well-being.
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It’s fair to say that enjoyment of a podcast would be severely limited without the human capacity to create and understand speech. That capacity has often been cited as a defining characteristic of our species, and one that sets us apart in the long history of life on Earth. Yet we know that other species communicate in complex ways. Studies of the neurological foundations of language suggest that birdsong, or communication among bats or elephants, originates with brain structures similar to our own. So why do some species vocalize while others don’t? In this episode, Erich Jarvis, who studies behavior and neurogenetics at the Rockefeller University, chats with Janna Levin about the surprising connections between human speech, birdsong and dance.
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