Afleveringen
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TWiP solves the case of the nonbinary patient in his 30s with a history HIV/AIDS presenting with 3 weeks of subjective fevers, chills, generalized weakness and voluminous ostomy output.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina NaulaSubscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Links for this episode Join the MicrobeTV Discord server Parasite of the Month: Leucochloridium paradoxum (the green-banded broodsac) Letters read on TWiP 282 TWiP study – information and surveyNew Case
39-year-old man originally from Guatemala, who moved to one of the NYC boroughs in 2023 and currently lives with his siblings and cousins, presented with headaches. He reports headaches for several months, possibly nearly 1 year. Over the past 2 weeks, he has had intermittent numbness on the left side of his face and in his left arm and foot, with difficulty standing due to sensory changes in his feet. He states these symptoms are new. He reports a fall related to the numbness but denies balance problems. He denies fever or chills. He has intermittent nausea and vomiting but denies diarrhea, abdominal pain, or other complaints. He works as a busboy in a restaurant and states that he only cleans and does not prepare food. In Guatemala, he used to eat street tacos containing pork and beef, sometimes with undercooked meat. He is a former smoker who quit 4 years ago after smoking for 10 years. He drinks alcohol 3–4 times per week, typically 2–4 drinks per occasion, but not daily. He reports no sexual activity for 1–2 years.
General: no acute distress
HEENT: NC/AT, anicteric, vEEG
Neck: supple, normal ROM
Lungs: clear to auscultation bilaterally
Heart: S1, S2 present, normal rate/rhythm
Abdomen: Soft. Nondistended. Nontender.
Neuro: AAOx3, no obvious focal deficits
Extremities: No cyanosis. No edema.\
Skin: Warm. Dry. No visible rash.
Psychiatric: Appropriate affect and mood for situation.CT HEAD WO IV CONTRAST-Cystic structures scattered along the subarachnoid space, for example, right sylvian fissure/frontotemporal cortical sulci, right > left suprasellar cistern, interpedicular cistern, basal cistern and left sylvian fissure. Associated mass effect with minimal leftward midline shift (0.2-0.3 cm). Calcifications at the left temporal region. There is no obvious acute intracranial hemorrhage.
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Music by Ronald Jenkees
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TWiP reviews gene expression in wood ants infected with the larval lancet fluke, which causes them to leave their nest and attach to a flower until they are eaten by a grazing mammal.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina NaulaSubscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Links for this episode Join the MicrobeTV Discord server Gene expression in wood ants infected with lancet fluke (Mol Ecol) Visualisation of the master manipulator in the brain of its ant host (Sci Rep) TWiP study – information and surveyBecome a patron of TWiP
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Music by Ronald Jenkees
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Zijn er afleveringen die ontbreken?
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TWiP solves the case of the 3 yo child, who recently immigrated to the US from Central America, in the ER with acute right lower quadrant abdominal pain and a rather active serpiginous wormlike 'thing' wiggling away in the child's appendix.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina NaulaSubscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Links for this episode Join the MicrobeTV Discord server Hero: Rudolf Ludwig Carl Virchow (1821-1902) Letters read on TWiP 280 TWiP study – information and surveyNew Case
3 yo child who recently immigrated to the US from Central America is brought in to the ER with acute right lower quadrant abdominal pain. The mother is concerned about the pain as well as nausea and vomiting. This is acute and the ER provider is concerned that this might be an acute surgical emergency. They order an US in this child and they are surprised to see a rather active serpiginous wormlike 'thing' wiggling away in the child's appendix. I was sent the Ultrasound video which I really enjoyed. What to do?
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Music by Ronald Jenkees
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TWiP reviews a phase 2 clinical trial of a recombinant vaccine against N. americanus glutathione S-transferase-1, an enzyme that performs a crucial enzymatic step in
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
hookworm blood feeding.Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Links for this episode Join the MicrobeTV Discord server Phase 2 hookworm vaccine clinical trial (Lancet Inf Dis) Phase 2 Schistosoma vaccine clinical trial (Vaccines) TWiP study – information and surveyBecome a patron of TWiP
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Music by Ronald Jenkees
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TWiP solves the case of the male in his 20s from Hokkaido, Japan, who developed fatigue and rash, followed by fever and myalgia 6 days later, after eating a raw bear eyeball.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server Hero: Sir Nicholas White (1951 – 2026) (Guardian, Lancet) Letters read on TWiP 278 TWiP study – information and surveyNew Case
3 yo child who recently immigrated to the US from Central America is brought in to the ER with acute right lower quadrant abdominal pain. The mother is concerned about the pain as well as nausea and vomiting. This is acute and the ER provider is concerned that this might be an acute surgical emergency. They order an US in this child and they are surprised to see a rather active serpiginous wormlike 'thing' wiggling away in the child's appendix. I was sent the Ultrasound video which I really enjoyed. What to do?
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Music by Ronald Jenkees
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TWiP 277: Rif-ing on river blindness April 21, 2026
TWiP reviews the global, regional, and national burden of Chagas disease, and comparison of doxycycline and rifampicin for the treatment of onchocerciasis.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server Burden of Chagas' disease (Lancet Inf Dis) Doxycycline vs rifampicin in treatment of river blindness (Open For Inf Dis) The kissing bug by Daisy Hernandez TWiP study – information and surveyBecome a patron of TWiP
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Music by Ronald Jenkees
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TWiP solves the case of the man in his 60s experiencing weight loss, fatigue, and loss of appetite.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server Hero: Bailey K. Ashford Letters read on TWiP 276 TWiP study – information and surveyNew Case
Male in his 20s from Hokkaido, Japan, developed fatigue and rash, followed by fever and myalgia 6 days later. He was a group of five individuals on a hunting trip prior to this and reports that 3 friends are just fine but one other individual developed similar symptoms. He reports that they had been hunting the Ussuri brown bear, which is larger and more aggressive than the Asian black bear. They had been successful and all five of them had consumed well cooked bear meat. He does share that he is aware of infectious risk from eating bear and thus the meat was well cooked. He and the one fellow hunter who did get sick were unique in that they each ate one of the eye balls raw. This is a tradition that is felt to give the consumer the great vision that these animals are purported to have.
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TWiP reviews the effectiveness of long-lasting spatial repellent emanators against malaria in humanitarian crisis settings in northern Nigeria, and Dengue suppression by male Wolbachia-infected mosquitoes.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server Spatial emanators for malaria control (Lancet Inf Dis) Dengue suppression with Wolbachia-infected mosquitoes (NEJM) Singapore Environmental Health Institute (TWiV 630) TWiP study – information and surveyBecome a patron of TWiP
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TWiP solves the case of the 40 year old male who travels to India and develops intestinal bloating and diarrhea.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server Hero: Glenn L. Hoffmann Fish and seafood consumption (Our World in Data) Wild fish vs aquaculture (Our World in Data) TWiP study – information and surveyBecome a patron of TWiP
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Music by Ronald Jenkees
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TWiP reviews intestinal parasites in dogs and their association with clinical manifestations of canine visceral leishmaniasis.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server Intestinal parasites in dogs (Vet Parasitol) Zoonotic protozoal diseases of companion animals (Clin Micr Rev) Canine visceral leishmaniasis in stray and owned dogs in Brazil (Acta tropica) Zoonotic protozoal diseases of companion animals (Clin Micr Rev) Canine visceral leishmaniasis (Leish Vet, pdf) Immune Responses in leishmaniasis (Trop Med Inf Dis) Canine leishmaniasis in the US (Today's Vet Prac) TWiP study - information and surveyBecome a patron of TWiP
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Music by Ronald Jenkees
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TWiP solves the case about the man with positive Strongyloides serology who is waiting for a kidney transplant.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server Chronic strongyloidiasis (Australian Family Physician) Hero: Gwendoleen Rees (Wikipedia) TWiP study – information and survey Letters read on TWiP 272 New Case40 year old man travels to India, is only there for a week before he develops problems. Bloating, diarrhea. Weathers the storm. Returns to US. Stool sent for testing. Some interesting results. Comes back positive for Hymenolepis nana, Blastocystis hominis, Giardia intestinalis. Recommended he take four tablets. Flatulence. HIV negative. He ate food that were prepared in the home but also out. Delhi area.
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Music by Ronald Jenkees
Dear TWiP listeners,
Have you ever wondered how TWiP shapes your understanding of science? We have! To find out more, Christina and the team are running a survey based study to learn more about how TWiP contributes to your scientific literacy and trust in science. Listen to the segment in this episode (TWiP 267) where Christina discusses the study's aims and scope.
Anyone who listens to TWiP can participate. The survey is anonymous and we do not collect personal data that could identify you. There are no potential disadvantages or harms in taking part, other than using a few minutes of your time. You will receive no direct benefit from taking part in this study. However, the information that is collected during this study will give us a better understanding of who our listeners are, and why they choose to listen to TWiP. We can use this understanding to make TWiP even better!
This is an academic study and we aim to disseminate our findings to the wider public, including you. For example, we'll have a conversation about the findings on a future episode of TWiP, we plan conference presentations and publication in a relevant academic journal
The project has been reviewed and approved by the University of Glasgow College of Medical, Veterinary & Life Sciences Ethics Committee. Application 200250013
You can find the study, detailed participant information, and consent information here:
TWiP study – information and survey
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TWiP explores female genital schistosomiasis and associated genital infections in Southern Malawi, a neglected tropical disease.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server Female genital schistosomiasis in Malawi (Parasitology) Mainstreaming female genital schistosomiasis (Parasitology) Female genital schistosomiasis (WHO) TWiP study – information and surveyBecome a patron of TWiP
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Music by Ronald Jenkees
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TWiP solves the case about the man with abnormal brain MRI, and presents a new case for your solving about a man with some electrolyte issues related to his end-stage renal disease.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server TWiP study – information and survey Letters read on TWiP 270 New CaseA man in his 20s is admitted to the hospital with some electrolyte issues related to his end-stage renal disease. Infectious disease is consulted as he has a report of a recent positive strongyloides serology test that was done as part of his pre-transplant evaluation. He reports no international travel, no interesting exposures.
Become a patron of TWiP
Send your questions and comments to [email protected]
Music by Ronald Jenkees
Dear TWiP listeners,
Have you ever wondered how TWiP shapes your understanding of science? We have! To find out more, Christina and the team are running a survey based study to learn more about how TWiP contributes to your scientific literacy and trust in science. Listen to the segment in this episode (TWiP 267) where Christina discusses the study's aims and scope.
Anyone who listens to TWiP can participate. The survey is anonymous and we do not collect personal data that could identify you. There are no potential disadvantages or harms in taking part, other than using a few minutes of your time. You will receive no direct benefit from taking part in this study. However, the information that is collected during this study will give us a better understanding of who our listeners are, and why they choose to listen to TWiP. We can use this understanding to make TWiP even better!
This is an academic study and we aim to disseminate our findings to the wider public, including you. For example, we'll have a conversation about the findings on a future episode of TWiP, we plan conference presentations and publication in a relevant academic journal
The project has been reviewed and approved by the University of Glasgow College of Medical, Veterinary & Life Sciences Ethics Committee. Application 200250013
You can find the study, detailed participant information, and consent information here:
TWiP study – information and survey
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TWiP travels to Toronto, CA for the American Society for Tropical Medicine and Hygiene conference where they meet up with Martin Grobusch to discuss his career and his work.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
Guest: Martin Grobusch
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Links for this episode Join the MicrobeTV Discord server Primaquine for blocking malaria transmission (Lancet Inf Dis) Pulmonary tuberculosis, Sierra Leone (New Microb New Inf) TWiP study – information and surveyBecome a patron of TWiP
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Music by Ronald Jenkees
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TWiP discusses a 41-year long human infection with Schistosoma mansoni, and CRISPR screens that reveal genes essential for Cryptosporidium survival in the host intestine.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server 41 year old Schistosoma infection (J Travel Med) Genes essential for Cryptosporidium survival in host intestine (Nat Comm)Become a patron of TWiP
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Music by Ronald Jenkees
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TWiP solves the case about the female who traveled to Brazil and upon returning home felt movements under her scalp on the back of her head, and present another case for your solving, a man with abnormal brain MRI.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
Guest: Eyal Leshem
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Links for this episode Join the MicrobeTV Discord server Life cycle of Dermatobia hominis (CDC) Letters read on TWiP 267 TWiP study - information and survey New CaseMan in his 40s, married with 2 children, on Eliquis for a prior DVT, diet-controlled diabetes, who is admitted for evaluation of an abnormal brain MRI. He left AMA but then developed vomiting and returned.
CT- Large peripherally enhancing mass lesion in the deep left cerebral hemisphere is associated with considerable vasogenic edema/infiltrative nonenhancing tumor. Mass effect results in left-to-right subfalcine herniation and entrapment of the right lateral ventricle. Findings are typical for glioblastoma. Intracranial abscess tumefactive multiple sclerosis and brain metastasis may mimic this appearance. Recommend supplemental imaging evaluation including gadolinium-enhanced MR brain.
MRI- Dominant heterogeneously enhancing mass in the left basal ganglia/peri-insular region measuring 3.1 cm AP by 2.8 cm TR by 2.9 cm cc, with surrounding vasogenic edema resulting in mass effect and midline shift, as detailed above, concerning for high grade glial neoplasm versus metastasis. Additional leptomeningeal nodule in the right postcentral sulcus. Additional smaller peripherally enhancing lesion in the right lateral temporal region with suggestion of leptomeningeal component and measures approximately 0.8 x 0.8 cm, with mild surrounding vasogenic edema.
They do a biopsy and pathology comes back as: – Brain tissue with extensive necrosis acute chronic inflammation, and rare microorganisms (on permanent section)
-Brain, designated "left brain lesion", excision:
– Brain tissue with extensive necrosis acute and chronic inflammation, reactive gliosis and occasional microorganisms
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TWiP explains research showing that treatment of baby wraps with an insect repellent, and oral dosing with ivermectin, are both effective measures to prevent malaria.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server Treated baby wraps prevent malaria (NEJM) Oral ivermectin prevents malaria (NEJM)Become a patron of TWiP
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Music by Ronald Jenkees
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TWiP solves the case about the parasite check in summer camp, and presents a new case about a woman who traveled to Brazil and developed furuncles on the back of her head.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula
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Links for this episode Join the MicrobeTV Discord server Hero: Francesco Redi Wikipedia: https://en.wikipedia.org/wiki/Francesco_Redi Linda Hall Library, Kansas: https://www.lindahall.org/about/news/scientist-of-the-day/francesco-redi/ Habermehl, G., (1994). Francesco Redi—Life and work, Toxicon 32 (4) https://doi.org/10.1016/0041-0101(94)90292-5. Letters read on TWiP 265 New CaseFrom Eyal Leshem, a returning case "provider"
43 years old female who travelled to Brazil on May 2025 for a two week dance class. The dance school is located in a farm two hour drive West of Rio de Janeiro.
Upon return to Israel she started feeling pricking and "movements" and under her scalp on the back of her head. She noted three non-healing furuncles on the back of her head A month after she returned movement and pricking in the back of her scalp increased, the furuncles enlarged and produced serous discharge. Several days before her ED visit she thinks an "object" dropped from the back of her scalp, but being outdoors, she could not locate the object.
On physical examination she is afebrile and her vitals are normal, and on the back of her head two indurated were detected under the hair on the back of her head. Serous discharge was produced by pushing the furuncles. A non-surgical office procedure led to immediate recovery and confirmed the diagnosis.
What was the parasite? What was the procedure?
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Vincent and Daniel discuss research showing that Toxoplasma gondii infection of the brain alters extracellular vesicle production and the communication between neurons and astrocytes.
Hosts: Vincent Racaniello and Daniel GriffinSubscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Links for this episode Join the MicrobeTV Discord server T. gondii infection of neurons (PLoS Path)Become a patron of TWiP
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Music by Ronald Jenkees
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TWiP solves the case of the world travelers with poppy-seed size dots embedded in their skin, then present a new case about parasite check in summer camp.
Hosts: Vincent Racaniello, Daniel Griffin, and Christina NaulaSubscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Links for this episode Join the MicrobeTV Discord server Hero: Dr Laurence Tetley Letters read on TWiP 263 New CaseIt is the first day of summer camp and the children are lined up for a parasite check. Some of the children have certificates that allow them to bypass the screening. Some of the parents are upset about this process commenting that this is not required by the state and report this could not be a problem for their children. One by one the children have their scalps examined and 2 of the children are asked to step to the side. The parents of these two children are contacted and told that they must address the identified concern before they can attend the camp. They are treated with a topical therapy on their hair with repeat in 1 week. The upset parents have several questions that hopefully our listeners can address.
-what is this all about?
-is anyone suggesting this is a hygiene issue?
-what is the most sensitive way to look for this problem?
-how do we know it is cured?
-feel free to talk about the life cycleBecome a patron of TWiP
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Music by Ronald Jenkees
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