Afleveringen
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Pelvic lymph node dissection down-graded. Systematic prostate biopsies no longer recommended. More clarity around PSMA PET/CT for staging. Surgery no longer recommended for cN1 prostate cancer. Yep the recent updates to the EAU Prostate Cancer Guidelines had a lot of important changes for the global urology community to digest. So we invited EAU Prostate Cancer Guideline Vice-Chair Derya Tilki, and Guideline Board Member Gianluca Giannarini, along with Elio Mazzone to join us for a deep dive into these major changes. All you need to know!
Even better on our YouTube channel -
The first of two Conference Highlight specials from the Advanced Prostate Cancer Consensus Conference, held in April 2024 in Lugano. This is our very favourite prostate cancer meeting and we are thrilled to bring you these highlight podcasts. In this epsiode we chat with Silke Gillessen, Derya Tilki, Jochen Walz, Neha Vapiwala, Dingwei Ye, and the lucky trainees who won a GU Cast Travel Award to attend this year's APCCC.
GU Cast Conference Highlights are supported by our friends at Bayer China, Gold Partners of GU Cast.
Even better on our YouTube channel -
Zijn er afleveringen die ontbreken?
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Didn't get to ASCO this year?? Us neither!! But not to worry, we checked in with Dr Marty Schoen who did, and brings us all the key highlights! Marty is a GU Medical Oncologist at the St Louis Veterans Affairs Medical Centre and the University of St Louis, Missouri. He runs through a smattering of stuff that caught his eye at ASCO this year. Thanks Marty!
Also on our YouTube channel -
For Urologists, there are not that many papers that come along where we can say - "this will almost immediately change my practice". But KEYNOTE-564 looks like one of those! A large phase III randomised trial of adjuvant pembro following nephrectomy for renal cell carcinoma in patients deemed at higher risk for recurrence. Regular listeners/viewers might remember we discussed this on GU Cast back in August 2021 when the disease-free survival endpoint was published in NEJM, and it would be fair to say we were cautious and kept saying "we need to wait for the overall survival data". Well here we are! Patients who received pembro for one year had a 38% reduced risk of death. Big news!
We are joined again by Dr Alex Kutikov, Urologist at Fox Chase Cancer Centre, who joined us on the original podcast. We are also joined by his colleague GU Medical Oncologist, Dr Matt Zibelman, who has a lot of experience in this area having been an investigator on the IMmotion 010 study. Unfortunately lead author Dr Toni Choueiri could not join us this time but he gets plenty of mentions!
This is a Themed Podcast supported by our Silver Partners, MSD, manufacturers of pembrolizomab, through an educational grant. MSD had no input into the content of this podcast.
Even better on our YouTube channel
Links:
Full NEJM paper
Previous GU Cast on K-564 -
Should we remove bladder cancers piece-meal by chopping them into little pieces, or should we try and remove en bloc with a margin around the base?? This very nice randomised controlled trial from our friends in Hong Kong demonstrates that the recurrence rate is significantly lower if we use the all-too-rarely used en bloc technique. Dr Jeremy Teoh from the Chinese University Hong Kong joins us to discuss his paper just published in European Urology.
Check out the YouTube version for a video of the technique.
Also available as an audio only podcast wherever you get your podcasts
Full paper here -
Today we have Dr Alicia Morgans, GU Medical Oncologist and Director of Survivorship at Dana Farber Cancer Institute, in the GU Cast studio for a chat. We wanted to ask Alicia to look forward and identify three big challenges we will face in metastatic prostate cancer over the next 5-10 years. What did we come up with??!! Tune in to find out!!
Even better on our YouTube channel -
In the first of our special episodes focussing on GU Oncology in China, we are delighted to welcome our inaugural GU Cast China Editor. Professor Yao Zhu, to the GU Cast studio. Yao is a Urologist at Fudan University Shanghai Cancer Centre, and is well known to all of us at GU Cast and Peter MacCallum Cancer Centre. As part of our Gold Partnership with Bayer Pharmaceuticals in China, Yao will help us put together some Themed Podcasts focussing on GU Oncology in China.
This first episode focuses on one of our favourite topics, metastatic hormone-sensitive prostate cancer (mHSPC). We chat with Yao and special guest, Professor Ning Zhang (Beijing Anzhen Hospital, affiliated to Capital Medical University), and learn a lot about prostate cancer in China!
Even better on our YouTube channel -
Great fun on the shores of Lake Lugano where the hosts of three of the best
-known podcasts in GU Oncology get together for a chat! Declan and Renu from GU Cast, join with Brian and Tom from Uromigos, and Gill from Oncoalert. How did it all start? Why did it all start?! Best moments, worst moments etc.
Tune if for a chat, and do please subscribe/like/follow all of us! Just search GU Cast/Uromigos/Oncoalert wherever you get your podcasts -
The 2nd ProsTIC Preceptorship is one of the most intense fora for the discussion of PSMA theranostics anywhere in the world! A biennial meeting in Melbourne with many of the world's leading experts in the field. Not just superb practical advice about how to get your prostate cancer theranostics program to the next level, but some amazing discussions on where to next for theranostics in prostate cancer. Plus, watch out for the shenanigans at the conference dinner!
Our Conference Highlights are supported by our friends at Bayer China.
Even better on our YouTube channel -
A new paper in the Journal of Clinical Oncology is reporting that the bowel and urinary side-effects of proton therapy (a high tech and very expensive type of radiotherapy), are no better than side-effects after standard high-quality radiotherapy (called IMRT). Quite a fuss on twitter when this paper came on line last week including from a fair few urologists, one of whom described proton therapy for prostate cancer as "a black eye for American healthcare"! (Thanks Scott!).
We chat with lead author Dr James Yu (Hartford, USA), and favourite GU Cast radiation oncologist Prof Shankar Siva to make sense of it all. And what does this mean for proton therapy in places like Australia who currently have no proton therapy facility.
Even better on our YouTube channel
Links:
JCO paper -
Professor Neil Fleshner (University of Toronto) drops into the GU Cast studio in Melbourne for an intriguing discussion! First we cover off the underrated topic of cardiac risks in patients starting androgen deprivation therapy and how we can reduce these for the benefit of our patients. Then we talk to Neil about entrepreneurship and his journey into very successful business ventures in recent years. He has some inspiring stories and some great advice for frustrated clinicians out there!
This episode is a Themed Podcast supported by our Bronze Partners, Cipla Australia.
Even better on our YouTube channel -
A big medical oncology love-in in the GU Cast studio today!! Professor Enrique Grande was visiting from MD Anderson Cancer Centre in Madrid to chat all about some of the sensational advances we have seen in metastatic bladder cancer in recent times. And we were also joined by old friend Professor Andrew Weickhardt from Austin Health in Melbourne to educate ourselves on what is an antibody drug conjugate and how does EV work. Plus lots of laughter!!
Even better on our YouTube channel. , Please do subscribe, rate and review. -
Axel Merseburger (Chief and Professor of Urology, Lubeck, Germany) was in Australia recently and popped into the GU Cast studio for a chat. Axel was at the USANZ ASM recently and also on a speaker tour supported by Janssen Pharmaceuticals, so we put together this Themed Podcast to pick his brains on high-risk prostate cancer and mHSPC in 2024.
This Themed Podcast is supported by Janssen Pharmaceuticals, Gold Partners of GU Cast.
Even better on our YouTube channel -
Declan and Renu bring you lots of highlights and interviews from the Urological Society of Australia & New Zealand (USANZ) Annual Scientific Meeting (ASM) which took place last week in Adelaide. Almost 1000 delegates descended on this beautiful part of the world, famous for its beaches and wineries.
Hear from Robert Nam, Paul Anderson, Nathan Lawrentschuk, Alan McNeill, Axel Merseburger, Dixon Woon, Michael Choong, Jo Cresswell, Anthony Ta, and Shane La Bianca who is Convenor of #USANZ25.
GU Cast Conference Highlights are supported by Bayer Pharmaceuticals (China), GU Cast Conference Highlights Partner.
Even better on our YouTube channel -
Needle through the rectum or needle through the skin?? Transrectal vs transperienal prostate biopsy is certainly a hot topic in prostate cancer, with the vast majority of men having their biopsy through the rectum rather than through the skin. It is quick, cheap and easy (for the urologist and the health system), but leaves the patient at risk of serious harm from infectious complications, at least according to historic reports.
Today Declan and Renu chat with Dr Jim Hu, Urologist at Cornell University in New York, and leader of the PREVENT trial, a randomised study of transrectal vs transperineal biopsy which has just been published in European Urology. We are also joined by Associate Professor Jeremy Grummet, Urologist at Alfred Health in Melbourne, and long-time advocate of transperineal biopsy. Did this trial finally establish transperineal as the new standard of care for men undergoing prostate biopsy?? Tune in to find out!
Even better on our YouTube channel
Links:
PREVENT trial in European Urology -
Two of the highest profile presentations at the recent ASCO GU Meeting were the plenary presentations of the CONTACT 02 trial, and the Keynote-564 trial. Generally speaking, these were well received; indeed quite enthusiastically received in some quarters! Not however in the quarter of prolific oncology commentator and Haematologist/Oncologist & Professor of Epidemiology, Dr Vinay Prasad! “Unethical” and “sh**ty” are just some of the terms he used to describe these in two episodes of his podcast, “Plenary Session”. Declan and Renu take Vinay to task for some of the somewhat personal attacks he makes on colleagues, but do enjoy listening to his critique, and indeed agree with many of his points!
Even better on our YouTube channel
Links:
Plenary Session podcast on Contact 02
Plenary Session podcast on Keynote-564
Dr Vinay Prasad Twitter -
Renu caught up with lots of experts and friends at ASCO GU in San Francisco recently and brings you all the highlights. Hear from Toni Choueiri, Matt Cooperberg (on that debate on renaming low-grade prostate cancer), Todd Morgan, Neha Vapiwala, Morgan Roupret, Sophia Kamran, Morgan Roupret, Sam Washington, plus a great chat with Tyler Seibert while they were out for an early morning run around beautiful San Francisco.
Even better on our YouTube channel
GU Cast Conference Highlights are supported by our Gold Partner, Bayer China. -
For all you enthusiasts of PSMA theranostics, we bring you another one of our fabulous ProsTIC/Prostate Cancer Foundation Global Webinars with some of the best minds in the business. This is the eighth of our collaborative webinars over the past four years and the focus today is bringing lutetium PSMA earlier in prostate cancer.
Two keynote lectures from Dr Oliver Sartor (Mayo Clinic) and Professor Louise Emmett (St Vincent's. Sydney)set the scene, focusing on brand-new data from the PSMAfore and Enza-P trials. We have an Asia-Pacific focus with a superb range of multidisciplinary panellists from across the region.
Co-Hosted by GU Cast’s own Dr Renu Eapen with Professor Michael Hofman from ProsTIC/Peter MacCallum Cancer Centre. They are joined in studio by friends of the podcast Dr Louise Kostos and Dr James Buteau.
Even better on our YouTube channel where you can see the presentations -
A must listen (actually a must WATCH!!) episode of GU Cast if you have any experience with the side-effects of treatment of prostate cancer. Whether you are a patient or loved one, or a surgeon/radiation oncologist/medical oncologist, or a nurse or allied health professional - then this is for you.
Declan and Renu chat about "A Touchy Subject" with the wonderful Victoria Cullen.
This one much better enjoyed on our YouTube channel!
Links:
A Touchy Subject -
We reveal the three winners of our APCCC Travel Awards 2024! These three trainees will be heading off to Lugano for the world's best prostate cancer meeting which takes place from 25-27 April on the shores of Lake Lugano.
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